Differentiation of gestational diabetes mellitus by nuclear magnetic resonance-based metabolic plasma analysis

Liu, Liping; Liu, Lenan; Wang, Junsong; Zheng, Qi; Bai, Jing; Sun, Lichao

doi:10.7555/jbr.35.20200191

Cited by 5 publications

(4 citation statements)

References 34 publications

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“…In mammalians, formate is a metabolic mediator among organisms, diet, and gut microbiota. Liu et al found that plasma formate concentration was positively correlated with body weight and BMI [ 52 ]. In humans, obese adults have higher plasma proline levels compared to normal-weight adults [ 53 , 54 ].…”

Section: Discussionmentioning

confidence: 99%

Metabolomic Characteristics of Cecum Contents in High-Fat-Diet-Induced Obese Mice Intervened with Different Fibers

Zhang

Cheng

Jiang

et al. 2023

Foods

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The aim of this study was to demonstrate the effect of single or mixed fibers (arabinoxylan, β-glucan, xyloglucan, and inulin) on the metabolome of cecum content in mice with obesity caused by a high-fat diet. Twenty-eight six-week-old male mice were divided randomly into seven groups (n = 4/group), including a normal-diet group (CON), a high-fat-diet group (HFD), and groups with the same high-fat diet but supplemented with arabinoxylan (HFAX), arabinoxylan + β-glucan (HFAβ), arabinoxylan + xyloglucan (HFAG), xyloglucan (HFXG), and xyloglucan + inulin (HFXI). A total of 66 molecules were identified and quantified in cecum content by proton nuclear magnetic resonance (1 H-NMR). The metabolomic profiles combined with statistical analysis revealed compounds distinguishing the control group from those supplemented with fibers. In detail, a high-fat diet could significantly elevate the concentrations of acetone and methionine (p < 0.05) while decreasing the levels of methanol, arabinose, acetate, and 3-hydroxyphenylacetate (p < 0.05) in the cecum contents of mice. Compared to HFD, the supplementation caused higher levels of fumarate and hypoxanthine (p < 0.05) and lower levels of phenylacetate, acetate, fucose, formate, proline, betaine, and trimethylamine N-oxide (TMAO) (p < 0.05). An enrichment analysis highlighted that the pathways mainly altered were amino sugar metabolism, aspartate metabolism, and arginine and proline metabolism. In conclusion, non-starch polysaccharide (NSP) supplementation could change the metabolomic profiles of cecum contents in obese mice as a result of a high-fat diet. Moreover, mixed NSPs exhibited more beneficial effects than singular form on gut metabolism.

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Section: Discussionmentioning

confidence: 99%

Metabolomic Characteristics of Cecum Contents in High-Fat-Diet-Induced Obese Mice Intervened with Different Fibers

Zhang

Cheng

Jiang

et al. 2023

Foods

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“…Indeed, maternal circulating SCFAs, in particular acetic, propionic and butyric acids, seemed to be closely related to clinical markers in GDM pregnancies and may exert favorable effects on physiological activities either directly or through GPR and HDAC, affecting the placental immunometabolism and fetal development at birth [ 53 ]. Instead, Liu et al [ 54 ] showed an increase in acetate levels both pre- and postpartum in mothers with GDM, although the greatest increases characterized mothers with GDM not treated with insulin.…”

Section: Discussionmentioning

confidence: 99%

Sardinian Infants of Diabetic Mothers: A Metabolomics Observational Study

Dessì,

Bosco,

Cesare Marincola

et al. 2023

IJMS

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Gestational diabetes mellitus (GDM) is a condition characterized by glucose intolerance, with hyperglycemia of varying severity with onset during pregnancy. An uncontrolled GDM can lead to an increased risk of morbidity in the fetus and newborn, and an increased risk of obesity or developing type 2 diabetes, hypertension or neurocognitive developmental impairment in adulthood. In this study, we used nuclear magnetic resonance (NMR) spectroscopy and gas chromatography–mass spectrometry (GS-MS) to analyze the urinary metabolomic profile of newborns of diabetic mothers (NDMs) with the aim of identifying biomarkers useful for the monitoring of NDMs and for early diagnosis of predisposition to develop related chronic diseases. A total of 26 newborns were recruited: 21 children of diabetic mothers, comprising 13 in diet therapy (NDM-diet) and 8 in insulin therapy (NDM-insulin), and 5 control children of non-diabetic mothers (CTR). Urine samples were collected at five time points: at birth (T1), on the third day of life (T2), one week (T3), one month (T4) and six months postpartum (T5). At T1, variations were observed in the levels of seven potential biomarkers (acetate, lactate, glycylproline/proline, isocitrate, N,N-dimethylglycine, N-acetylglucosamine and N-carbamoyl-aspartate) in NMD-insulin infants compared to NDM-diet and CTR infants. In particular, the altered metabolites were found to be involved in several metabolic pathways such as citrate metabolism, glycine, serine and threonine metabolism, arginine and proline metabolism, amino sugar and nucleotide sugar metabolism, and pyruvate metabolism. In contrast, these changes were not visible at subsequent sampling times. The impact of early nutrition (maternal and formula milk) on the metabolomic profile was considered as a potential contributing factor to this finding.

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“…Succinate levels rise before delivery in women with gestational diabetes mellitus (GDM), particularly those receiving insulin treatment [ 39 ]. This suggests that the increase in succinate observed may primarily be due to insulin administration or GDM severity.…”

Section: Diabetes and The Succinate–sucnr1 Axismentioning

confidence: 99%

Type 2 diabetes and succinate: unmasking an age-old molecule

Fernández-Veledo,

Marsal-Beltran,

Vendrell

2024

Diabetologia

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Beyond their conventional roles in intracellular energy production, some traditional metabolites also function as extracellular messengers that activate cell-surface G-protein-coupled receptors (GPCRs) akin to hormones and neurotransmitters. These signalling metabolites, often derived from nutrients, the gut microbiota or the host’s intermediary metabolism, are now acknowledged as key regulators of various metabolic and immune responses. This review delves into the multi-dimensional aspects of succinate, a dual metabolite with roots in both the mitochondria and microbiome. It also connects the dots between succinate’s role in the Krebs cycle, mitochondrial respiration, and its double-edge function as a signalling transmitter within and outside the cell. We aim to provide an overview of the role of the succinate–succinate receptor 1 (SUCNR1) axis in diabetes, discussing the potential use of succinate as a biomarker and the novel prospect of targeting SUCNR1 to manage complications associated with diabetes. We further propose strategies to manipulate the succinate–SUCNR1 axis for better diabetes management; this includes pharmacological modulation of SUCNR1 and innovative approaches to manage succinate concentrations, such as succinate administration and indirect strategies, like microbiota modulation. The dual nature of succinate, both in terms of origins and roles, offers a rich landscape for understanding the intricate connections within metabolic diseases, like diabetes, and indicates promising pathways for developing new therapeutic strategies. Graphical Abstract

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Differentiation of gestational diabetes mellitus by nuclear magnetic resonance-based metabolic plasma analysis

Cited by 5 publications

References 34 publications

Metabolomic Characteristics of Cecum Contents in High-Fat-Diet-Induced Obese Mice Intervened with Different Fibers

Metabolomic Characteristics of Cecum Contents in High-Fat-Diet-Induced Obese Mice Intervened with Different Fibers

Sardinian Infants of Diabetic Mothers: A Metabolomics Observational Study

Type 2 diabetes and succinate: unmasking an age-old molecule

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