Differentiation of isomeric Lewis blood groups by positive ion electrospray tandem mass spectrometry

UV-activated multilayer nanomatrix provides one-step tunable carbohydrate structural characterization in MALDI-MS

“…7a and b. However either 1–3 or 1–4 linkage loss generates isobaric Z and Y fragment ions, which are non-structurally unique markers, and the previously reported semi-empirical approach by MALDI-PSD 49 and electrospray ion trap mass spectrometry 50 may fail to differentiate the isomeric Lewis-type oligosaccharides. As shown in Fig.…”

Rapid identification of erythrocyte phospholipids in Sprague–Dawley rats by ultra high performance liquid chromatography with electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry

“…Furthermore, the employment of a high-resolution mass spectrometer, such as a Q-TOF instrument, capable of high mass accuracy in both full scan and MS/MS stages, which are very informative for structure characterization especially for biological samples [25], has been investigated. In particular, quadrupole ion trap MS can distinguish isomers according to their characteristic fragment ions, and TOF-MS that can provide the accurate mass measurements and formulae of non-target compounds is able to identify non-target compounds tentatively [26][27][28]. In the present study, a rapid UHPLC-ESI-Q-TOF-MS method was established for successfully separating and identifying 83 phospholipids of erythrocyte in Sprague-Dawley (SD) rats.…”

UPLC-Q-TOF/MS-based screening and identification of the main flavonoids and their metabolites in rat bile, urine and feces after oral administration of Scutellaria baicalensis extract

“…Especially, TOF/MS which can provide the accurate mass measurements and formula of nontarget compounds is able to fast identify non-target compounds tentatively (Kaur et al, 2006). Quadrupole ion trapmass spectrometry can distinguish isomers according to their characteristic fragment ions (Ferreira et al, 2010). So, chemical compounds in TCM prescriptions can be identified or tentatively characterized by combining the two techniques.…”