“…Studies of patients with profound brain dysfunction, characterized by focal or diffuse encephalopathies (Wernicke-Korsakoff disease), senile dementias or mental retardation have shown that assessments of intellectual functioning, using measures of IQ, correlate significantly with the amounts of rapid eye movement activity (5-7, 20, 33). Although our group of medical depressive patients was not as intellectually impaired as groups of brain-damaged patients previously studied, their neuro psychological performance was poor, with scores on the BVRT comparable to the results reported in patients with severe brain damage (40). Thus, phasic REM activity measures appear to be significant predictors of the presence of medical pathology among patients with a depressive syndrome and suggesting that the use of REM sleep parameters may represent a more accurate method of detecting such pathology rather than neuropsychological testing.…”