Differentiation of primary chordoma, giant cell tumor and schwannoma of the sacrum by CT and MRI

Si, Ming-Jue; Wang, Chengsheng; Ding, Xiaoyi; Yuan, Fei; Du, Lianfang; Zhang, Wei-Bin

doi:10.1016/j.ejrad.2013.08.034

Cited by 37 publications

(33 citation statements)

References 22 publications

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“…14 ADC can identify further characteristics of many tumors with malignant potential. 15 We hypothesized that recurrent or residual chordoma that acquires aggressive features with time also shows a decrease in the ADC value. The aim of this study was to explore the role of the ADC as a predictor of outcome in patients with chordomas.…”

Section: 13mentioning

confidence: 99%

Role of the Apparent Diffusion Coefficient as a Predictor of Tumor Progression in Patients with Chordoma

Sasaki

Moritani

Belay³

et al. 2018

AJNR Am J Neuroradiol

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Section: 13mentioning

confidence: 99%

Role of the Apparent Diffusion Coefficient as a Predictor of Tumor Progression in Patients with Chordoma

Sasaki

Moritani

Belay³

et al. 2018

AJNR Am J Neuroradiol

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“…On imaging, both are characterized with osteolytic bone destruction, lesions of heterogeneous signal intensity, and cystic regions. 1,2 Chordoma was most often present in the clival and sacral regions, and the lesion location was commonly used as the diagnostic indicator. 3 Therefore, when GCT occur in basilar clivus, cervical C1–2 or sacral vertebra, it may be inaccurately diagnosed as chordoma based on the location.…”

mentioning

confidence: 99%

“…3 Therefore, when GCT occur in basilar clivus, cervical C1–2 or sacral vertebra, it may be inaccurately diagnosed as chordoma based on the location. 2 In sacrum, chordoma and GCT of bone are the top one and two common primary tumors. 4 Also, as more chordomas were reported to occur in various segments of the spine, misdiagnosing the lesion based on its location can occur.…”

mentioning

confidence: 99%

Morphological and dynamic contrast enhanced MR imaging features for the differentiation of chordoma and giant cell tumors in the Axial Skeleton

Xing

et al. 2016

Magnetic Resonance Imaging

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Purpose: To characterize the morphological and dynamic-contrast-enhanced (DCE) MRI features of chordoma and giant cell tumor (GCT) of bone occurring in the axial skeleton. Materials and Methods: A total of 13 patients with chordoma and 26 patients with GCT who received conventional T1, T2, and DCE-MRI on 3 Tesla MR scanners were retrospectively identified and analyzed. Two radiologists evaluated morphological features independently, including the lesion location, expansile bone changes, vertebral compression, presence of paraspinal soft tissue mass, fibrous septa, and the signal intensity on T1WI and T2WI. The inter-observer agreement was evaluated by kappa test. The DCE kinetics was measured to obtain the initial area under curve (IAUC) and the wash-out slope; also the two-compartmental pharmacokinetic model was applied to obtain Ktrans and kep. The diagnostic accuracy was evaluated by CHAID decision tree and ROC analysis. Results: Chordomas were more likely to show soft tissue mass than GCTs (13/13 = 100% versus 15/26 = 58%; P = 0.007), as well as fibrous septa (9/13 = 69% versus 0; P<0.001). In decision tree analysis, presence of fibrous septa and lesion location yield 31/39 = 79% accuracy. The DCE-MRI pharmacokinetic parameters Ktrans and kep of GCTs were significantly higher than those of chordomas, 0.136 0.65 versus 0.0660.04 (1/min) for Ktrans, 0.6260.22 versus 0.176 0.12 (1/min) for kep, P<0.001 for both. If using kep = 0.43/min as the cut-off value, it achieved 100% sensitivity and 92% specificity to differentiate chordoma from GCT, with an overall accuracy of 37/39 = 95%. The IAUC was highly correlated with Ktrans (r = 0.94), and the slope was highly correlated with kep (r = 0.95). Conclusion: Several morphological features were significantly different between chordoma and GCT, but their diagnostic performance was inferior to that of DCE-MRI.

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“…A characteristic MRI finding of chordomas is the lobulated appearance. [5] And the septations, which make tumors lobulated or latticed, are enhanced. [5] In addition, the alveolate presentation is also a significant finding in most cases of reported ICCs.…”

mentioning

confidence: 99%

“…[5] And the septations, which make tumors lobulated or latticed, are enhanced. [5] In addition, the alveolate presentation is also a significant finding in most cases of reported ICCs. Therefore, we speculate that lobulated and alveolate appearances, as well as characteristic MRI images, are useful diagnostic clues of ICCs.…”

mentioning

confidence: 99%

Diagnostic Clues and Treatment of Intradural Cranial Chordoma

Zeng

Fan

et al. 2016

Chinese Medical Journal

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Differentiation of primary chordoma, giant cell tumor and schwannoma of the sacrum by CT and MRI

Cited by 37 publications

References 22 publications

Role of the Apparent Diffusion Coefficient as a Predictor of Tumor Progression in Patients with Chordoma

Role of the Apparent Diffusion Coefficient as a Predictor of Tumor Progression in Patients with Chordoma

Morphological and dynamic contrast enhanced MR imaging features for the differentiation of chordoma and giant cell tumors in the Axial Skeleton

Diagnostic Clues and Treatment of Intradural Cranial Chordoma

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