Differentiation of prostate cancer from benign prostate hypertrophy using dual-echo dynamic contrast MR imaging

Muramoto, Satoshi; Uematsu, Hideyuki; Kimura, Hirohiko; Ishimori, Yoshiyuki; Sadato, Norihiro; Oyama, Nobuyuki; Matsuda, Tsuyoshi; Kawamura, Yasutaka; Yonekura, Yoshiharu; Okada, Kenichiro; Itoh, Harumi

doi:10.1016/s0720-048x(01)00468-5

Cited by 26 publications

(20 citation statements)

References 21 publications

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“…[11,12] Our meta-analysis showed that the K trans and K ep values were significant in the differential diagnosis of PCa and noncancerous CG tissue, but the V e value was not significant. Subgroup analyses revealed no significant differences in the ability of K trans and K ep values to differentiate PCa and noncancerous CG tissue in Whites, when a magnetic field strength of 1.5 T was used, or when a Siemens machine was used (Table 4).…”

Section: Discussionmentioning

confidence: 99%

Differential diagnosis of prostate cancer and noncancerous tissue in the peripheral zone and central gland using the quantitative parameters of DCE-MRI

et al. 2016

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Background:The objective of this meta-analysis was to evaluate the clinical usefulness of Ktrans, Kep, and Ve values in the differential diagnosis of prostate cancer (PCa) and noncancerous tissue in the peripheral zone (PZ) and central gland (CG).Methods:A search was conducted of the PubMed, MEDLINE, EMBASE, Cochrane Library, China National Knowledge Infrastructure, and Wanfang databases from January 2000 to October 2015 using the search terms “prostate cancer,” “ dynamic contrast-enhanced (DCE),” “magnetic resonance imaging,” “Ktrans,” “Kep,” and “Ve.” Studies were selected and included according to strict eligibility criteria. Standardized mean differences (SMDs) and 95% confidence intervals (CIs) were used to compare Ktrans, Kep, and Ve values between PCa and noncancerous tissue.Results:Fourteen studies representing 484 patients highly suspicious for prostate adenocarcinoma were selected for the meta-analysis. We found that Ktrans values measured by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) were significantly higher in PCa tissue than in noncancerous tissue in the PZ (SMD 1.57, 95% CI 0.98–2.16; z = 5.21, P <0.00001) and CG (SMD 1.19, 95% CI 0.46–1.91; z = 3.21, P = 0.001). Kep values measured by DCE-MRI were significantly higher in PCa than in noncancerous tissue in the PZ (SMD 1.41, 95% CI 0.92–1.91; z = 5.59, P < 0.00001) and CG (SMD 1.57, 95% CI 0.69–2.46; z = 3.49, P = 0.0005). Ve values generated by DCE-MRI were slightly higher in PCa than in noncancerous tissue in the PZ (SMD 0.72, 95% CI 0.17–1.27; z = 2.58, P = 0.010), but sensitivity analysis found that the Ve value was unstable for differentiation between PCa and noncancerous PZ tissue. However, there was no significant difference in the Ve value between PCa and noncancerous CG tissue (SMD −0.29, 95% CI −1.18, 0.59; z = 0.65, P = 0.51).Conclusion:Our meta-analysis shows that Ktrans and Kep were the most reliable parameters for differentiating PCa from noncancerous tissue and were critical for evaluation of the internal structure of cancer. The Ve value was not helpful for distinguishing PCa from noncancerous CG tissue; its ability to distinguish between PCa and noncancerous PZ tissue remains uncertain.

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Section: Discussionmentioning

confidence: 99%

Differential diagnosis of prostate cancer and noncancerous tissue in the peripheral zone and central gland using the quantitative parameters of DCE-MRI

et al. 2016

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“…Evaluation of transition zone cancer with imaging, including conventional MRI, gadolinium-enhanced MRI with dynamic data acquisition, and sonography [8][9][10][11][12], is difficult because transition zone cancer is the site of origin of benign prostatic hyperplasia, which can have a heterogeneous appearance [3,[13][14][15][16][17][18][19]. Proton MR spectroscopic imaging has been successfully applied to the diagnosis of cancer in the peripheral zone on the basis of the elevation of choline and the reduction of citrate in cancerous tissue [3,20,21].…”

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Conventional MRI Capabilities in the Diagnosis of Prostate Cancer in the Transition Zone

Sugimura

Kaji

et al. 2006

American Journal of Roentgenology

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“…These tumors have been described by several teams [9][10][11][12][13]. However, their morphometric features on MRI have not been investigated in detail, nor have these features been related to data from whole-mount radical prostatectomy (RP) specimens.…”

Section: Introductionmentioning

confidence: 99%

Dynamic contrast-enhanced MRI of anterior prostate cancer: morphometric assessment and correlation with radical prostatectomy findings

et al. 2008

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The purpose of the study was to relate morphometric features of prostate cancers in the anterior compartment of the prostate by dynamic contrast-enhanced (DCE) MRI to subsequent histopathologic findings. We prospectively performed DCE-MRI before biopsy in patients with suspected prostate cancer and selected those showing both a suspicious lesion at MRI and positive biopsies in the anterior compartment of the gland. Tumor contours, margins, largest surface areas and volumes were assessed at MRI and histopathology, when available. Anterior compartment tumors were classified according to transition zone (TZ) boundaries with the peripheral zone (PZ) or with the anterior fibromuscular stroma (SFMA). Forty-three patients were included in this study [median PSA 12.7 ng/ml (3.6-72)]. Whole-mount radical prostatectomy specimens were available in 27 cases. Of the anterior cancers, 89% had ill-defined margins at T2-weighted MRI. Cancer location and contour established at MRI agreed well with histopathology in the 27 cases. Median largest surface area and volume were 1.38 cm(2) (0.35-5.82) and 1.01 cc (0.15-7.4) for MRI versus 1.86 cm(2) (0.2-14) and 2.84 cc (0.33-28.92) for histopathology with respective correlation coefficients (r(2)) of 0.73 and 0.69. The site of origin could be accurately determined for the 15 tumors of less than 3 cc. We found a good relationship between DCE-MRI and histopathology for localization, morphologic description and volume assessment of anterior prostate cancers.

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Differentiation of prostate cancer from benign prostate hypertrophy using dual-echo dynamic contrast MR imaging

Cited by 26 publications

References 21 publications

Differential diagnosis of prostate cancer and noncancerous tissue in the peripheral zone and central gland using the quantitative parameters of DCE-MRI

Differential diagnosis of prostate cancer and noncancerous tissue in the peripheral zone and central gland using the quantitative parameters of DCE-MRI

Conventional MRI Capabilities in the Diagnosis of Prostate Cancer in the Transition Zone

Dynamic contrast-enhanced MRI of anterior prostate cancer: morphometric assessment and correlation with radical prostatectomy findings

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