Differentiation of prostate cancer from benign lesions using strain index of transrectal real-time tissue elastography

Zhang, Yan; Tang, Jie; Li, Yanmi; Xiang, Fei; Lv, Faqin; He, Enhui; Li, Qiuyang; Shi, Huaiyin

doi:10.1016/j.ejrad.2011.02.037

Cited by 67 publications

(64 citation statements)

References 18 publications

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“…Also, in the characterization of thyroid nodules as malignant or benign, SR was reported to have sensitivity of 85-89% with specificity of 80-82% in two meta-analyses [10,11]. In trans-rectal applications in prostate and rectal tumors, SR has been used to improve B-mode identification of malignant tumors with adequate accuracy (ROC-AUC > 90%) [12,13]. The aim of this study was to retrospectively compare variability in strain-based elastography quantified by SR, recorded in three different applications using Real-Time Elastography in homogeneous tissue-mimicking media, in resected tissue from bowel lesions, and during the endoscopic ultrasound (EUS) of focal pancreatic lesions.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Strain Ratio as a Quantification Tool in Strain Imaging

et al. 2018

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Ultrasound-based strain imaging is available in several ultrasound (US) scanners. Strain ratio (SR) can be used to quantify the strain recorded simultaneously in two different user-selected areas, ideally exposed to the same amount of stress. The aim of this study was to evaluate SR variability when assessed in an in-vitro setup with a tissue-mimicking phantom on resected tissue samples and in live tissue scanning with endoscopic applications. We performed an in vivo retrospective analysis of SR variability used for quantification of elastic contrasts in a tissue-mimicking phantom containing four homogenous inclusion in 38 resected bowel wall lesions and 48 focal pancreatic lesions. Median SR and the inter-quartile range (IQR) were calculated for all external and endoscopic ultrasound (EUS) applications. The IQR and median provide a measure of SR variability focusing on the two percentiles of the data closest to the median value. The overall SR variability was lowest in a tissue-mimicking phantom (mean QR/median SR: 0.07). In resected bowel wall lesions representing adenomas, adenocarcinomas, or Crohn lesions, the variability increased (mean IQR/Median: 0.62). During an in vivo endoscopic examination of focal pancreatic lesions, the variability increased further (mean IQR/Median: 2.04). SR variability increased when assessed for different targets with growing heterogeneity and biological variability from homogeneous media to live tissues and endoscopic application. This may indicate a limitation for the accuracy of SR evaluation in some clinical applications.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Strain Ratio as a Quantification Tool in Strain Imaging

et al. 2018

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“…Salomon and colleagues 14 reported that elastography could detect prostate cancer foci within the prostate with good accuracy and had the potential to increase ultrasound-based prostate cancer detection. Zhang and colleagues 15 showed that there was significant difference of strain ratio values between the benign and malignant prostate lesions. Dudea and colleagues 16 found that sonoelastography definitely improved the detection of prostate cancer.…”

Section: -12mentioning

confidence: 99%

Strain elastography in the characterization of renal cell carcinoma and angiomyolipoma

Keskin

Güven

Keskin³

et al. 2015

CUAJ

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E67 ORIGINAL RESEARCHCite as: Can Urol Assoc J 2015;9(1-2):e67-71. http://dx.doi.org/10.5489/cuaj.2349 Published online February 9, 2015. AbstractIntroduction: We evaluate the diagnostic performance of strain elastography to differentiate renal cell carcinoma (RCC) from angiomyolipoma (AML). Methods: Strain elastography was performed in 65 patients (mean age 55.5 years; range: 32-81) who had renal lesions (24 AMLs and 41 RCCs) prospectively. Lesions were classified according to lesion size and histological subtypes. The strain ratios of the RCCs and AMLs were evaluated by a radiologist. The area under the curve and the cut-off point were used to assess diagnostic performance. Sensitivity, specificity, and positive and negative predictive values were obtained. Results: In assessing the mean strain ratio, we divided the groups in 3 according to size: (1) <20-mm lesions; (2) 20-to 40-mm lesions; and (3) >40-mm lesions; the respective mean strain ratios were: 1.5 ± 0.5 (range: 0.06-5.92), 2.8 ± 0.4 (range: 0.17-9.92), 2.7 ± 0.3 (range: 0.08-6.15). When RCCs and AMLs were compared, there was a statistically significant difference in the strain ratio among the 3 groups divided per lesion size (p < 0.01). For the strain ratio, the mean ± standard deviation was 1.1 ± 0.1 for AMLs and 3.4 ± 0.3 for RCCs (p < 0.01). When lesion subtypes were compared, there was a statistically significant difference in the strain ratio between the AML and clear cell RCC (p < 0.01). Conclusions: For assessing renal lesions, strain elastography and strain ratio values may be useful in differentiating RCCs from AMLs. IntroductionUltrasound (US) elastography is a new radiological modality. In conventional B-mode imaging, tissue hardness in real time is represented in colour. Because most malignant tumours are harder than benign tissues, benign and malignant tissues were differentiated significantly by this technique. In the literature, a good correlation between strain elastography and histologic analysis was reported, with high sensitivity and specificity for differentiation between benign and malignant masses in breast tissue. 1 We hypothesized that evaluation of tissue elasticity might be useful for renal mass characterization. Tan and colleagues found significant differences between strain ratios for angiomyolipomas (AMLs) and renal cell carcinomas (RCCs) (p < 0.01).2 The aim of our study, therefore, was to prospectively determine the diagnostic efficiency of sonoelastography for differentiating RCCs from AMLs. Methods Study populationThere were 65 patients in our study population (28 men and 37 women) who underwent US, including elastography of a renal mass, at our institution between March 2012 and February 2013. The mean age of patients was 55.5 ± 12.3 (range: 32-81). The study population had various renal masses, including 41 RCCs and 24 AMLs. The RCCs were diagnosed by resection. The histopathological examination was performed by our pathologists. Histological subtype was clear cell carcinoma in 26 patients, papillary cell carcinoma ...

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“…For the prostate there is to-date only one published study that investigated the value of strain ratio of prostate lesions [22]. Zhang et al reported that the strain ratio could provide supplementary information regarding prostate lesions in order to better differentiate between benign and malignant lesions.…”

Section: Review 255mentioning

confidence: 99%

Strain Elastography of Breast and Prostata Cancer: Similarities and Differences

Daniaux

Auer

Zordo

et al. 2015

Fortschr Röntgenstr

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Typically both breast and prostate cancer present as tissue with decreased elasticity. Palpation is the oldest technique of tumor detection in both organs and is based on this principle. Thus an operator can grade a palpable mass as suspicious for cancer. Strain elastography as modern ultrasound technique allows the visualization of tissue elasticity in a color coded elastogram and can be understood as technical finger. The following article shows similarities and differences of ultrasound strain elastography in the diagnosis of breast and prostate cancer. Key Points: ??In prostata cancer elastography, in breast cancer B-mode is the primary sonographic search modality. ??The diagnostic value of the search modalities change with increasing age. ??A cut-off value for a strain ratio is hard to obtain in the elastography of the prostata, because there is no stabile reference tissue in the prostata. Citation Format: ??Daniaux M, Auer T, De Zordo T et?al. Strain Elastography of Breast and Prostata Cancer: Similarities and Differences. Fortschr R?ntgenstr 2016; 188: 1???6

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Differentiation of prostate cancer from benign lesions using strain index of transrectal real-time tissue elastography

Cited by 67 publications

References 18 publications

Strain Ratio as a Quantification Tool in Strain Imaging

Strain Ratio as a Quantification Tool in Strain Imaging

Strain elastography in the characterization of renal cell carcinoma and angiomyolipoma

Strain Elastography of Breast and Prostata Cancer: Similarities and Differences

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