2023
DOI: 10.1111/jpi.12904
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Differentiation of T cells producing interleukin‐17 (Th17) against the background of exogenous melatonin during pregnancy

Natalya Sergeevna Glebezdina,
Irina Valerievna Nekrasova,
Anna Alexandrovna Olina
et al.

Abstract: The population of T lymphocytes producing IL‐17 (Th17) plays a dual role during pregnancy and its activity is tightly controlled during this period. One of the factors involved in this process may be the pineal hormone melatonin, which can effectively regulate this T cell population. Here we have shown that exogenous melatonin in pharmacological concentrations is able to enhance the differentiation of Th17 cells of pregnant women in vitro. The stimulatory effects of melatonin were limited to in the first trime… Show more

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“…Alterations in NK cells, T regulatory cells (Tregs), Th17, and Th1/Th2 ratio may be associated with pregnancy-related complications, pregnancy loss, implantation failure, and preeclampsia ( 92 ). Melatonin affects the T cell subpopulation in gestation by increasing the differentiation of Th17 and Tregs ( 94 , 95 ). Melatonin rhythm may be synchronized with Th1/Th2 cell populations in protecting and maintaining fetal survival ( 96 ).…”
Section: Melatonin In the Placentamentioning
confidence: 99%
“…Alterations in NK cells, T regulatory cells (Tregs), Th17, and Th1/Th2 ratio may be associated with pregnancy-related complications, pregnancy loss, implantation failure, and preeclampsia ( 92 ). Melatonin affects the T cell subpopulation in gestation by increasing the differentiation of Th17 and Tregs ( 94 , 95 ). Melatonin rhythm may be synchronized with Th1/Th2 cell populations in protecting and maintaining fetal survival ( 96 ).…”
Section: Melatonin In the Placentamentioning
confidence: 99%