Differentiation of the Sexually Dimorphic Nucleus in the Preoptic Area of the Rat Brain Is Inhibited by Postnatal Treatment with an Estrogen Antagonist

Döhler, K.-D.; Srivastava, S.S.; Shryne, James E.; Jarząb, Barbara; Sipos, Andrea; Gorski, Roger A.

doi:10.1159/000123907

Cited by 116 publications

(52 citation statements)

References 15 publications

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“…In contrast, purported antiestrogens, such as tamoxifen (195), demasculinize the male, including the size of the sexually dimorphic nucleus of the preoptic area such that it resembles that observed in the female. Exposure of newborn female rats to these xenoestrogens during the critical periods of sexual differentiation has been shown to perturb reproductive processes in later life, presumably by altering the development of the neural mechanisms regulating gonadotropin secretion.…”

Section: Controversy Within the Scientific Communitymentioning

confidence: 94%

Environmental Endocrine Disruption: An Effects Assessment and Analysis

Crisp¹,

Clegg²,

Cooper³

et al. 1998

Environmental Health Perspectives

165

145

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Section: Controversy Within the Scientific Communitymentioning

confidence: 94%

Environmental Endocrine Disruption: An Effects Assessment and Analysis

Crisp¹,

Clegg²,

Cooper³

et al. 1998

Environmental Health Perspectives

165

145

View full text Add to dashboard Cite

“…This sex difference is the result of estrogenic action during development. Females treated with estradiol benzoate (EB) perinatally develop masculine sexually dimorphic nuclei (Dohler et al, 1984a), while treatment of males with estrogen antagonists results in feminine sexually dimorphic nuclei (Dohler et al, 1984b). Furthermore, DHT treatment is ineffective in masculinizing the sexually dimorphic nucleus in females, and males given androgen antagonists perinatally develop sexually dimorphic nuclei that are no different from those of normal males (Dohler et al, 1986).…”

Section: Motoneuron Death and The Establishment Of Snb Cell Numbermentioning

confidence: 99%

The spinal nucleus of the bulbocavernosus: Firsts in androgen-dependent neural sex differences

Sengelaub

Forger

2008

Hormones and Behavior

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Cell number in the spinal nucleus of the bulbocavernosus (SNB) of rats was the first neural sex difference shown to differentiate under the control of androgens, acting via classical intracellular androgen receptors. SNB motoneurons reside in the lumbar spinal cord and innervate striated muscles involved in copulation, including the bulbocavernosus (BC) and levator ani (LA). SNB cells are much larger and more numerous in males than in females, and the BC/LA target muscles are reduced or absent in females. The relative simplicity of this neuromuscular system has allowed for considerable progress in pinpointing sites of hormone action, and identifying the cellular bases for androgenic effects. It is now clear that androgens act at virtually every level of the SNB system, in development and throughout adult life. In this review we focus on effects of androgens on developmental cell death of SNB motoneurons and BC/LA muscles; the establishment and maintenance of SNB motoneuron soma size and dendritic length; BC/LA muscle morphology and physiology; and behaviors controlled by the SNB system. We also describe new data on neurotherapeutic effects of androgens on SNB motoneurons after injury in adulthood.

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“…Testosterone or estradiol treatment of female rats during the perinatal period permanently increases the size of the SDN-POA [Döhler et al, 1984a;Tarttelin and Gorski, 1988;Rhees et al, 1990a, b]. Conversely, castration of males or treating them with anti-estrogen inhibits development of the SDN-POA [Gorski et al, 1978;Döhler et al, 1984bDöhler et al, , 1986. In both ferrets and gerbils, gonadal steroids alter morphology in adulthood as well as during development.…”

Section: Hormonal Control Of Structurementioning

confidence: 99%

Sexual Dimorphisms in Avian and Reptilian Courtship: Two Systems that Do Not Play by Mammalian Rules

Wade¹

1999

Brain Behav Evol

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Sexual dimorphisms in the central nervous system exist in numerous vertebrate species, and in many cases these structural differences between males and females parallel differences in the display of reproductive behaviors. Often both the behavioral and anatomical differences are controlled by exposure to gonadal steroid hormones, either during ontogeny or in adulthood. This article reviews some of the evidence supporting the hypothesis that in mammals, testosterone or its metabolites regulate the structure and function of neural and muscle systems involved in the control of masculine sexual behaviors. It then describes data suggesting that the mechanisms regulating sexually dimorphic courtship systems in zebra finches and green anole lizards are not completely parallel to the mammalian systems. Finally, some directions for future study are suggested, with the hope that they will stimulate thought about the nature of comparisons made across vertebrate models when investigators are attempting to determine both which morphological sex differences are important to the control of the reproductive behaviors, and which mechanisms regulating both structure and function are widely employed or are unique.

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Differentiation of the Sexually Dimorphic Nucleus in the Preoptic Area of the Rat Brain Is Inhibited by Postnatal Treatment with an Estrogen Antagonist

Cited by 116 publications

References 15 publications

Environmental Endocrine Disruption: An Effects Assessment and Analysis

Environmental Endocrine Disruption: An Effects Assessment and Analysis

The spinal nucleus of the bulbocavernosus: Firsts in androgen-dependent neural sex differences

Sexual Dimorphisms in Avian and Reptilian Courtship: Two Systems that Do Not Play by Mammalian Rules

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