Differentiation of umbilical cord mesenchymal stem cells into steroidogenic cells in comparison to bone marrow mesenchymal stem cells

Wei, Xing; Peng, Gongfeng; Zheng, Shusen; Wu, Xia

doi:10.1111/j.1365-2184.2012.00809.x

Cited by 52 publications

(37 citation statements)

References 39 publications

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“…This method can also differentiate human BM-MSCs into cortisol-producing cells in response to adrenocorticotropic hormone stimulation, which are similar to the zona fasciculata cells of the adrenal gland. Additionally, BM-MSCs transform to steroidogenic cells by adenovirus-mediated transient expression of SF-1 Tanaka et al, 2007;Wei et al, 2012;Yanase et al, 2006). These studies are consistent with the concept that SF-1 is a master regulator for steroidogenesis.…”

Section: Differentiation Of Stem Cells Into Steroidogenic Cells By Sfsupporting

confidence: 74%

“…As is the case for BM-MSCs, MSCs derived from other tissues can be differentiated into steroidogenic cells using the above methods (Gondo et al, 2008;Wei et al, 2012;Yazawa et al, 2014;Yazawa et al, 2010). However, these methods are not applicable to pluripotent stem cells, such as ES cells, iPS cells, and embryonal carcinoma cells, because SF-1 and LRH-1 are cytotoxic to these cells Yazawa et al, 2006).…”

Section: Differentiation Of Stem Cells Into Steroidogenic Cells By Sfmentioning

confidence: 99%

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Regulation of Steroidogenesis, Development, and Cell Differentiation by Steroidogenic Factor-1 and Liver Receptor Homolog-1

et al. 2015

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Section: Differentiation Of Stem Cells Into Steroidogenic Cells By Sfsupporting

confidence: 74%

Section: Differentiation Of Stem Cells Into Steroidogenic Cells By Sfmentioning

confidence: 99%

Regulation of Steroidogenesis, Development, and Cell Differentiation by Steroidogenic Factor-1 and Liver Receptor Homolog-1

et al. 2015

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“…UCMSCs have unique properties between those of embryonic and adult stem cells. hUCMSCs express significantly less human leukocyte antigen-1 (HLA-1); they show a more beneficial immunogenic profile, a stronger immune tolerance, and a faster proliferation rate than BMMSCs [5,27,28]. These characteristics favor xenotransplantation.…”

Section: Discussionmentioning

confidence: 99%

Hepatocyte Growth Factor Gene-Modified Mesenchymal Stem Cells Augment Sinonasal Wound Healing

Zheng

et al. 2015

Stem Cells and Development

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This study was designed to investigate the effects of hepatocyte growth factor (HGF) transgenic mesenchymal stem cells (HGF-MSCs) on wound healing in the sinonasal mucosa and nasal epithelial cells (NECs). We also sought to determine whether HGF-MSCs and MSCs can migrate into the injured mucosa and differentiate into ciliated cells. Human HGF-overexpressing umbilical cord MSCs (hHGF-UCMSCs) were established, and upregulation of hHGF expression was confirmed by real-time PCR (RT-PCR) and enzyme-linked immunosorbant assay (ELISA). To investigate the paracrine effect of human MSCs (hMSCs) on nasal epithelial repair, hMSC-and HGF-MSC-conditioned media (CM) were used in NEC proliferation assays and in an in vitro scratch-wound repair model. The in vivo sinonasal wound-healing model was established, and all enrolled rabbits were randomly assigned to four groups: the GFP-MSC group, the HGF-MSC group, the Ad-HGF group, and the surgery control group. The average decreased diameter was recorded, and the medial wall of the maxillary sinus was removed for histological analysis and scanning electron microscopy. Collagen deposition in the wound tissue was detected via Masson trichrome (M&T) staining. The distribution of MSCs and HGFMSCs was observed by immunofluorescence. MSCs improved nasal wound healing both in vivo and in vitro. HGF overexpression in MSCs augmented the curative effects. Reduced collagen deposition and transforming growth factor beta1 (TGF-b1) expression were detected in the HGF-MSC group compared with the MSC-, Ad-HGF-, and phosphate-buffered saline-treated groups based on M&T staining and ELISA. The enhanced therapeutic effects of HGF-MSCs were accompanied by decreased level of the fibrogenic cytokine TGF-b1. In addition, both HGF-MSCs and MSCs can migrate to the injured mucosa and epithelial layer.

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“…Adenovirus-mediated transient expression of SF-1 also differentiates BM-MSCs into steroidogenic cells with the capacity for de novo synthesis of various steroid hormones [53]. In addition to BM-MSCs, these methods can induce differentiation of MSCs derived from various tissues such as adipose, umbilical cord blood, and the uterus [24,52,58,59]. However, these methods are not applicable to embryonic stem (ES) cells, embryonal carcinoma cells, or terminally differentiated cells such as fibroblasts and adipocytes.…”

Section: Induction Of Steroidogenic Cell Using Stem Cells Derived Fromentioning

confidence: 99%

Overviews of Stem Cells for Gonadal and Adrenal Steroidogenic Cells

Yazawa

Imamichi

Miyamoto

et al. 2015

AJLS

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Gonads and adrenal glands are the primary organs for the production of steroid hormones in mammals. Steroid hormones play important roles in development and are essential for the maintenance of homeostasis during adult life. To supply sufficient amounts of hormones, gonads and adrenal glands maintain their functions by replenishment of steroidogenic cells. It has been hypothesized that stem/progenitor cells of steroidogenic cells are important for this phenomenon. In fact, such cells have been recently identified in gonads and adrenal glands. However, steroid hormone production decreases progressively with age, causing problems such as menopausal disorders in women. Although steroid hormones are administered to these patients, induction of steroidogenic cells from stem cells is a potential strategy to prevent menopausal disorders. Here, we review the current knowledge on stem cells that replenish steroid hormone-producing cells in the gonads and adrenal glands. We also discuss induction of steroidogenic cells from stem cells derived from non-steroidogenic organs.

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Differentiation of umbilical cord mesenchymal stem cells into steroidogenic cells in comparison to bone marrow mesenchymal stem cells

Abstract: UC-MSCs had significantly higher potential of steroidogenic differentiation than BM-MSCs; thus, UC-MSCs could be favourable cells of choice for cell-based therapy for steroidogenic insufficiency compared to BM-MSCs.

Cited by 52 publications

References 39 publications

Regulation of Steroidogenesis, Development, and Cell Differentiation by Steroidogenic Factor-1 and Liver Receptor Homolog-1

Regulation of Steroidogenesis, Development, and Cell Differentiation by Steroidogenic Factor-1 and Liver Receptor Homolog-1

Hepatocyte Growth Factor Gene-Modified Mesenchymal Stem Cells Augment Sinonasal Wound Healing

Overviews of Stem Cells for Gonadal and Adrenal Steroidogenic Cells

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