1977
DOI: 10.1016/0024-3205(77)90432-5
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Differentiation of β-adrenoceptors in right atrium, diaphragm and adipose tissue of the rat, using stereoisomers of propranolol, alprenolol, nifenalol and practolol

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Cited by 62 publications
(32 citation statements)
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“…In view of the selectivity and potency of BRL 37344 as a lipolytic agent (Arch et al, 1984;Wilson et al, 1984) and reports that ,B-adrenoceptors on fat cells are atypical (Arch et al, 1984;Bojanic et al, 1984;Harms et al, 1977;Wilson et al, 1984) the question arises as to whether the putative adrenoceptor in the guinea-pig ileum and the atypical fiadrenoceptor on adipocytes are the same. Evidence in support of this notion is provided by the similar rank order and relative potency of agonists at the putative adrenoceptor in the ileum and at the atypical f-adrenoceptor in rat adiopocytes.…”
Section: Discussionmentioning
confidence: 99%
“…In view of the selectivity and potency of BRL 37344 as a lipolytic agent (Arch et al, 1984;Wilson et al, 1984) and reports that ,B-adrenoceptors on fat cells are atypical (Arch et al, 1984;Bojanic et al, 1984;Harms et al, 1977;Wilson et al, 1984) the question arises as to whether the putative adrenoceptor in the guinea-pig ileum and the atypical fiadrenoceptor on adipocytes are the same. Evidence in support of this notion is provided by the similar rank order and relative potency of agonists at the putative adrenoceptor in the ileum and at the atypical f-adrenoceptor in rat adiopocytes.…”
Section: Discussionmentioning
confidence: 99%
“…Other evidence in favour of a distinctive, atypical P-adrenoceptor type in rat adipocytes was found in a study on the potency ratios of stereoisomers of Padrenoceptor antagonists (Harms et al, 1977) an approach introduced and reviewed by Patil et aL (1974).…”
Section: Oh R --Chch2-nh-r F-adrenoceptor Blocking Agents and Lipolysmentioning
confidence: 99%
“…Both atypical ,B-adrenoceptors and f3-adrenoceptors are resistant to blockade by (-)-propranolol at concentrations that saturate up to 99% of both f,-and 112-adrenoceptor populations (Harms et al, 1977; additional evidence reviewed in Arch but are blocked by (-)-bupranolol (Walter et al, 1984;Kaumann, 1989;Langin et al, 1991;Blin et al, 1994). Experiments were therefore carried out in the absence and presence of (-)-propranolol alone and in combination with (-)-bupranolol.…”
Section: Introductionmentioning
confidence: 99%