Differentiation‑related zinc finger protein 750 suppresses cell growth in esophageal squamous cell carcinoma

Choi, Sheyne Sta Ana; Ko, Josephine Mun‐Yee; Yu, V. Y. H.; Ning, Lvwen; Lung, Maria Li

doi:10.3892/ol.2021.12774

Cited by 2 publications

(3 citation statements)

References 34 publications

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“… 13 , 22 – 24 ZNF750 acts as a tumor suppressor by regulating long non-coding RNA and cell cycle activator E2F transcription factor 2 (E2F2). 78 – 80 Notch signaling regulates squamous differentiation in a normal esophagus. 81 The Notch pathway was exclusively activated by recurrent mutations of Notch pathway-related genes, including NOTCH1, NOTCH3 , and F-box and WD repeat domain-containing-7 ( FBXW7 ) in ESCC but not in EAC.…”

Section: Clinicopathological and Molecular Features Of Esccmentioning

confidence: 99%

Potent molecular-targeted therapies for advanced esophageal squamous cell carcinoma

et al. 2023

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Esophageal cancer (EC) remains a public health concern with a high mortality and disease burden worldwide. Esophageal squamous cell carcinoma (ESCC) is a predominant histological subtype of EC that has unique etiology, molecular profiles, and clinicopathological features. Although systemic chemotherapy, including cytotoxic agents and immune checkpoint inhibitors, is the main therapeutic option for recurrent or metastatic ESCC patients, the clinical benefits are limited with poor prognosis. Personalized molecular-targeted therapies have been hampered due to the lack of robust treatment efficacy in clinical trials. Therefore, there is an urgent need to develop effective therapeutic strategies. In this review, we summarize the molecular profiles of ESCC based on the findings of pivotal comprehensive molecular analyses, highlighting potent therapeutic targets for establishing future precision medicine for ESCC patients, with the most recent results of clinical trials.

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Section: Clinicopathological and Molecular Features Of Esccmentioning

confidence: 99%

Potent molecular-targeted therapies for advanced esophageal squamous cell carcinoma

et al. 2023

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“…In digestive system‐related cancers, ZNF750 is frequently mutated in esophageal squamous cell carcinoma (ESCC). ZNF750 represses SNAI1 and inhibits EMT process, which acts as a tumor suppressor in ESCC 92,93 . Likewise, ZNF471 is hypermethylated in ESCC and improves the expression of MAPK10/JNK3 and PCDH family genes to inhibit tumor cell colony formation, viability, migration, and invasion 94 .…”

Section: Role Of Znfs In Different Tumorsmentioning

confidence: 99%

“…ZNF750 represses SNAI1 and inhibits EMT process, which acts as a tumor suppressor in ESCC. 92,93 Likewise, ZNF471 is hypermethylated in ESCC and improves the expression of MAPK10/JNK3 and PCDH family genes to inhibit tumor cell colony formation, viability, migration, and invasion. 94 Additionally, ZNF281 is associated with clinical factors such as grade, stage, and radiotherapy of oral squamous cell carcinoma (OSCC), which may be used as a potential diagnostic marker.…”

Section: Other Cancersmentioning

confidence: 99%

The role of zinc finger proteins in malignant tumors

Zhao,

Wen,

Zhang

et al. 2023

The FASEB Journal

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Zinc finger proteins (ZNFs) are the largest family of transcriptional factors in mammalian cells. Recently, their role in the development, progression, and metastasis of malignant tumors via regulating gene transcription and translation processes has become evident. Besides, their possible involvement in drug resistance has also been found, indicating that ZNFs have the potential to become new biological markers and therapeutic targets. In this review, we summarize the oncogenic and suppressive roles of various ZNFs in malignant tumors, including lung, breast, liver, gastric, colorectal, pancreatic, and other cancers, highlighting their role as prognostic markers, and hopefully provide new ideas for the treatment of malignant tumors in the future.

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Differentiation‑related zinc finger protein 750 suppresses cell growth in esophageal squamous cell carcinoma

Cited by 2 publications

References 34 publications

Potent molecular-targeted therapies for advanced esophageal squamous cell carcinoma

Potent molecular-targeted therapies for advanced esophageal squamous cell carcinoma

The role of zinc finger proteins in malignant tumors

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