Differentiation SELEX approach identifies RNA aptamers with different specificities for HIV-1 capsid assembly forms
Paige R. Gruenke,
Miles D. Mayer,
Rachna Aneja
et al.
Abstract:The HIV-1 capsid protein (CA) assumes distinct assembly forms during replication, each presenting unique, solvent-accessible surfaces that facilitate multifaceted functions and host factor interactions. However, contributions of individual CA assemblies remain unclear, as the evaluation of CA in cells presents several technical challenges. To address this need, we sought to identify CA assembly form-specific aptamers. Aptamer subsets with different specificities emerged from within a highly converged, pre-enri… Show more
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