Differenzierung von Müdigkeit und Fatigue bei Multipler Sklerose - Vergleich unterschiedlicher Messinstrumente

Kotterba, Sylvia; Eren, Esma; Fangerau, Tanja; Jp, Malin; Sindern, Eckhart

doi:10.1055/s-2003-43464

Cited by 7 publications

(2 citation statements)

References 6 publications

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“…Depressed MS patients develop fatigue 3.6 times more than non-depressed ones, according to Alarcia et al findings [ 34 ]. In two distinct studies Beata LR et al [ 35 ] showed a linear correlation between MADRS and FSS scores, confirming the findings of previous works [ 36 , 37 ]. Differently, Vercoulen et al [ 38 ] found no significant association between fatigue and depression in patients with MS.…”

Section: Discussionsupporting

confidence: 85%

Fatigue, sleepiness and depression in multiple sclerosis: defining the overlaps for a better phenotyping

et al. 2022

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Background and objectives To define the boundaries and the overlaps between fatigue, sleepiness and depression in patients with multiple sclerosis (MS) by using different tools for each dimension, including instrumental sleep analysis. Methods In this cross-sectional, observational study, 71 MS patients (males/females: 20/51; mean age: 48.9 ± 10.5 years) filled in clinical questionnaires and performed polysomnography followed by maintenance of wakefulness test (MWT). Frequency and reciprocal overlap of sleepiness, fatigue and depression in MS were expressed by Eulero-Venn diagrams; standard multiple regression was used to assess the ability of symptoms to predict each other. Results There was a high percentage of fatigued (70%), somnolent (45%) and depressed (27%) patients. Fatigue had the strongest overlap and correlated with both depression (beta: 0.52, p < 0.001) and sleepiness (beta: 0.74, p < 0.001). Somnolence and depression were nearly always accompanied by fatigue and were well differentiated from each other by MWT. Four MS subgroups were identified that had: (1) fatigue only; (2) fatigue and sleepiness (3) fatigue and depression; (4) fatigue, sleepiness and depression. Discussion The subjective and objective tools are not able to clearly distinguish fatigue from sleepiness and depression, while only a test of vigilance can be helpful in separating somnolence and depression from each other.

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Section: Discussionsupporting

confidence: 85%

Fatigue, sleepiness and depression in multiple sclerosis: defining the overlaps for a better phenotyping

et al. 2022

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“… Pí Wèi Lùn “MS” clinical presentation Western Medicine established signs & symptoms of MS Fatigue Central fatigue – associated with demyelination of the central nervous system (CNS). 80% of the MS patients have fatigue, or more specifically lassitude 24 Somnolence Sleepiness – day time sleepiness that can often be mistaken by fatigue 32 Debilitated limbs, Atonic flaccidity of the legs Paresis, Paralysis Insufficient essence spirit Depression – the description may be referring to depression; 50% of the MS patients show depression, 36% show anxiety, 10% with pseudobulbar affect (PBA), and many others with mood swings. 25 Dysthymia may also be present.…”

Section: Discussionmentioning

confidence: 99%

The “Treatise on the spleen and stomach” (Pí Wèi Lùn) as the first record of multiple sclerosis in the medical literature – A hypothesis based on the analysis of clinical presentation and herbal medicine

Fuzimoto

Brigo

2020

Journal of Traditional and Complementary Medicine

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Background The “Treatise on the spleen and stomach” ( Pí Wèi Lùn ) is the work of the scholar and physician Li Gao ( Jin-Yuan dynasties, 1115–1368 C.E., China). Li Gao described a clinical presentation that today would fall under the diagnosis of Multiple Sclerosis (MS) and proposed the treatment with herbal medicine and nutritional guidelines. The PWL is well known for its application in the treatment of MS and autoimmune conditions. However, this theoretical “MS” has not yet been analyzed through a scientific investigation, and research on its herbal formulations for MS is scant. Methods We analyzed the PWL “MS” clinical presentation considering biomedical diagnostic criteria and neurological correlates. To support our review, we searched Pubmed for studies on the PWL main herbal formulas and their herbs/isolates used for the believed “MS” which treated experimental autoimmune encephalomyelitis (EAE)/MS. Results We found a very close correlation between the PWL “MS” and the current MS diagnosis. Twenty four studies on the herbs-isolates showed significant amelioration of EAE, neuronal damage, and demyelination. Discussion Collectively, Astragali radix , Ginseng radix , Glycyrrhizae radix , and berberine containing Phellodendri cortex reduced the severity of EAE through different signaling pathways and mechanisms of action. These herbs provided a wide range of properties such as anti-inflammatory, anti-oxidant, anti-microglial activation, anti-infiltration of leukocytes, apoptotic/anti-apoptotic balance, and neuronal protection. Conclusion Our review proposes that the PWL is the first record of MS in the medical literature. Its formulas and herbs-isolates offer a fertile area for MS research and an invaluable potential for its treatment.

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Multiple Sklerose

Kotterba¹

2020

Springer Reference Medizin

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Differenzierung von Müdigkeit und Fatigue bei Multipler Sklerose - Vergleich unterschiedlicher Messinstrumente

Cited by 7 publications

References 6 publications

Fatigue, sleepiness and depression in multiple sclerosis: defining the overlaps for a better phenotyping

Fatigue, sleepiness and depression in multiple sclerosis: defining the overlaps for a better phenotyping

The “Treatise on the spleen and stomach” (Pí Wèi Lùn) as the first record of multiple sclerosis in the medical literature – A hypothesis based on the analysis of clinical presentation and herbal medicine

Multiple Sklerose

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