Differing disintegration and dissolution rates, pharmacokinetic profiles and gastrointestinal tolerability of over the counter ibuprofen formulations

Abstract

The formulations of OTC ibuprofen differ in their disintegration and dissolution properties, pharmacokinetic profiles and apparent gastrointestinal tolerability. Spontaneously reported abdominal symptoms were five times lower with the liquid gelatine capsule as compared with ibuprofen acid despite a 30% increase in C .

Pengaruh ball milling pada dispersi padat ibuprofen dengan pembawa HPMC terhadap ukuran partikel dan kecepatan disolusi kapsul

“…Pelarut tersebut disesuaikan dengan medium disolusi yang diacu berdasarkan kompendial baik Farmakope Indonesia maupun USP [14,20]. Pelarut dapar fosfat 7,2 mensimulasikan kondisi di duodenum dengan asumsi bahwa sediaan akan mengalami tingkat disintegrasi dan kelarutan yang cukup besar [21]. Besarnya kelarutan tersebut disebabkan ibuprofen lebih terionisasi pada dapar fosfat 7,2.…”

Clinical pharmacological particular qualities of original ibuprofen different forms in treatment of diseases manifesting by pain

“…Сравнению скорости растворения, всасывания и биодоступности быстродействующих форм Нурофена и обычных таблеток ибупрофена был посвящен ряд исследований [24,25]. В них установлено, что ибупрофена натрия дигидрат имел такую же максимальную концентрацию (Cmax), что и ибупрофена лизинат, и ибупрофен в капсулах в растворе.…”

Abrupt disintegration of highly porous particles in early stage dissolution

“…The dissolution phenomenon of them can be summarised as: i) wetting -water penetrates into the pores due to capillary force; ii) immersion -powder sinks into water; iii) disintegration -solid bridges between primary particles dissolve; and iv) dissolution -soluble primary particles dissolve [5]. Heavy study in orally disintegrating tablet in pharmaceutics points out that disintegration is one of the effective paths to accelerate the whole dissolution process [6][7][8][9][10][11]. It could be realised through adding superdisintegrant into the tablets [12][13][14][15][16].…”