Differing effects of antiinsulin serum and antiinsulin receptor serum on 123I-insulin metabolism in rats.

Sodoyez, Jean-Claude; Goffaux, F Sodoyez; Frenckell, R. von; Vos, C. J. De; Treves, Susan; Kahn, C. Ronald

doi:10.1172/jci111848

Cited by 16 publications

(7 citation statements)

References 31 publications

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“…Apparently immunoglobulin aggregates are taken up by intravascular schistosomes but also eliminated preferentially by Kupffer cells, even if it is not known to what extent the radiolabelling might have altered the immunoglobulin and thereby affected its relative distribution after injection. Such uptake was similar to the described elimination of immune complexes as seen by autoradiography and apparently mediated by both Fc and C3b receptors (22,23).…”

Section: Discussionsupporting

confidence: 82%

Immunoglobulin uptake and processing by Schistosoma mansoni

Thors

Jokiranta²,

Meri³

et al. 2006

Parasite Immunology

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Intravascular Schistosoma mansoni worms seem to take up immunoglobulins from blood by surface Fc-receptors, but the process whereby bound immunoglobulins are processed by the parasite is poorly understood. We here present morphological data suggesting that two distinct main processes are involved: Host immunoglobulins were seen at two distinct locations in the parasite: in the frontal part of the enteric tube, the oesophagus, and as a fine granular staining at the surface and in the subtegumental region. The latter staining pattern corresponds to host immunoglobulin localization in discrete organelle-like aggregates tentatively identified as 'discoid or elongate bodies' at the ultrastructural level using immunogold staining. Immunoglobulin uptake by intravascular worms was also demonstrated in vivo after passive administration of 125I-labelled rabbit and mouse immunoglobulins. Radiolabelled immunoglobulins were taken up by the worms and shown to localize as fine strands running perpendicular to the parasite surface. Our results suggest that intravascular schistosomes take up host immunoglobulins both as part of their enteric digestion and by a surface Fc-receptor-mediated mechanism, involving transport and processing within organelles, 'elongate bodies'. Immunoglobulins taken up by intravascular schistosomes form a distinct organelle-like granules, which seem to be processed within the excretory system of the parasite.

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Section: Discussionsupporting

confidence: 82%

Immunoglobulin uptake and processing by Schistosoma mansoni

Thors

Jokiranta²,

Meri³

et al. 2006

Parasite Immunology

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“…On the other hand, there is a direct relationship between the amount of liver radioactivity and AIgG2 but an inverse relationship between liver binding and AIIgG1 in the injection bolus. As previously shown with autoradiographic techniques, 123I-ins alone is predominantly associated with the hepatocytes whereas '25I-ins-GPAIS complexes are essentially associatedwith the Kuppfer cells (21). Fig.…”

Section: Discussionsupporting

confidence: 60%

“…cretion and active transport by the gastric mucosa, salivary and thyroid glands, so that at a later time after '231-ins injection, e.g. 30 min, the biodistribution of radioactivity is essentially that of iodide and characterized by dense activity in the bladder, stomach, and neck (8,19,21).…”

Section: Discussionmentioning

confidence: 99%

Scintigraphic distribution of complexes of antiinsulin antibodies and 123I-insulin. In vivo studies in rats.

Sodoyez-Goffaux¹,

Sodoyez²,

Koch³

et al. 1987

J. Clin. Invest.

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“…It is speculated that the 123 I-aspart-insulin radioactivity in the liver may be too low to be detected using the scintigraphic method owing to the rapid degradation of aspart-insulin in the liver. It has been reported that the liver plays a critical role in the clearance of plasma insulin and the intravenously administered insulin is rapidly metabolized by the liver with a biological half-life of about 6 min [36].…”

Section: Biodistribution Studymentioning

confidence: 99%