Differing effects of metoprolol and propranolol on large vessel and microvessel responsiveness in a porcine model of coronary spasm

Muto, Mitsuru; Saitoh, Shu‐ichi; Osugi, Taku; Matsumoto, Ken; Aikawa, Kazuhiko; Onogi, Futoshi; Ishibashi, Toshiyuki; Maruyama, Yukio

doi:10.1097/01.mca.0000236283.64059.70

Cited by 2 publications

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“…Five patients underwent the provocation test under administration of β ‐blockers, and coronary artery spasm was induced in four of the patients in the AF group. It has been reported that nonselective β ‐blockers worsened coronary artery spasm and prognosis, but that β ‐1 selective β ‐blockers were effective in preventing coronary artery spasm . In our study, all five patients who received β ‐blockers were administrered β ‐1 selective β ‐blockers.…”

Section: Discussionmentioning

confidence: 65%

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The Relationship between Paroxysmal Atrial Fibrillation and Coronary Artery Spasm

Kawakami

Ohno

Tanaka

et al. 2013

Pacing Clinical Electrophis

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Section: Discussionmentioning

confidence: 65%

“…It has been reported that nonselective β-blockers worsened coronary artery spasm and prognosis, 31,32 but that β-1 selective β-blockers were effective in preventing coronary artery spasm. [33][34][35][36][37][38] In our study, all five patients who received β-blockers were administrered β-1 selective β-blockers.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Paroxysmal Atrial Fibrillation and Coronary Artery Spasm

Kawakami

Ohno

Tanaka

et al. 2013

Pacing Clinical Electrophis

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Mechanistic Insights of Coronary Vasospasm and New Therapeutic Approaches

Saitoh

Takeishi

Maruyama

2015

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PREFACECoronary vasospasm is a major health problem in Japan because of its high incidence and severity. Great advances have been made in clinical research and therapy focusing on coronary vasospastic angina. In particular, the Ca antagonist has contributed to improvements in the quality of life of patients with coronary vasospastic angina. Moreover, several animal models of coronary vasospasm have provided insight into the pathophysiology of this disease. However, the mechanisms of coronary vasospasm and microvascular spasm remain elusive. We have studied the mechanisms of coronary vasospasm, including microvascular spasm, in an animal model. The present study was designed to develop an animal model of coronary vasospasm and to elucidate the mechanisms and pathophysiology of coronary vasospasm and new therapeutic approaches. The topics discussed in this article include : (1) the role of endothelial and smooth muscle function on the genesis of coronary vasospasm, (2) the participation of reactive oxygen species in coronary vasospasm, and (3) aging and spasm. We hope that the contents of this volume will be useful to "students of coronary vasospasm" at many levels, including the clinician involved in cardiovascular studies and scientists in various disciplines who are interested in a comprehensive, in -depth review of coronary vasospasm.Coronary vasospasm can be defined as a reversible, focal, and intense coronary vasoconstriction that typically occurs in an epicardial conduit artery segment. The definitive diagnosis of a coronary artery spasm is determined by the direct visualization of such a reversible focal subtotal coronary occlusion at a site distal to the catheter tip. This is generally associated with regional ST segment elevation and angina. The first description of coronary artery spasm was likely made by Heberden in 1802 when he described angina as spasmodic, occurring at rest and related to emotional factors. 1) For over 100 years, this presumed vasoconstrictor phenomenon was implicated in myocardial infarction and angina pectoris. It was not until the mid -twentieth century that the correlation between atherosclerotic plaques and angina pectoris was realized. 2) This observation lessened the interest in vasospasms as an etiology of angina, particularly because later investigations failed to observe spasms very often in patients with angina pectoris. 3) In the latter third of the twentieth century, the demonstration of coronary vasospasm during angina (Prinzmetal's angina) and as a precursor to myocardial infarction 4) resurrected interest in the vasomotor etiology of angina pectoris. 5) In recent years, our understanding of the endothelial modulation of coronary tone has evolved, and substantial insight has been provided from a number of studies over the past three decades. However, the mechanism of coronary vasospasm remains elusive.Some investigations have reported that endothelial dysfunction is present at the site of a coronary vasospasm. 6,7) However, several lines of evidence indicate that coro...

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Differing effects of metoprolol and propranolol on large vessel and microvessel responsiveness in a porcine model of coronary spasm

Abstract: The beta1-selective blocker metoprolol was effective to prevent coronary vasospasm.

Cited by 2 publications

References 24 publications

The Relationship between Paroxysmal Atrial Fibrillation and Coronary Artery Spasm

The Relationship between Paroxysmal Atrial Fibrillation and Coronary Artery Spasm

Mechanistic Insights of Coronary Vasospasm and New Therapeutic Approaches

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