We report a rare case of difficult intubation because of trachea deformation after therapy for diphtheria and subsequent tracheostomy at childhood. The patient was admitted to be subjected to a Bentall procedure, because of ascending aorta dilatation. With a detailed preanesthetic assessment and simulation for intubation by using three-dimensional technology, he was successfully intubated and the operation was accomplished uneventfully. 3D-printed models of the difficult airway enhance imaging of difficult anatomy, assist in simulation and management of potentially problematic intubation, and can be a valuable tool when dealing with airways with potential anatomical malformations. K E Y W O R D S 3D printing, fiberoptic intubation, tracheal distortion, tracheal stenosis How to cite this article: Antoniou T, Papadopoulos K, Kampanarou S, Ftikos P, Perreas K, Theodoraki K. Secondary tracheal distortion in an adult patient after therapy for diphtheria at childhood.