Difficult-to-control asthma

Sheehan, William J.; Phipatanakul, Wanda

doi:10.1097/aci.0000000000000195

Cited by 48 publications

(20 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A 20% increased length of hospital stay was also found in ETS-exposed asthmatic children [57]. ETS exposure also impacts on asthma control with decreased response to inhaled corticosteroids and impaired histone deacetylase-2 function, possibly contributing to steroid resistance in asthmatic children [58]. In utero tobacco smoke exposure increased age-related airway hyperresponsiveness and reduced the efficacy of inhaled corticosteroids in asthmatic children [59].…”

Section: Resultsmentioning

confidence: 99%

The association between environmental tobacco smoke exposure and childhood respiratory disease: a review

Vanker

Gie

Zar

2017

Expert Review of Respiratory Medicine

151

View full text Add to dashboard Cite

Introduction: Childhood respiratory illness is a major cause of morbidity and mortality particularly in low and middle-income countries. Environmental tobacco smoke (ETS) exposure is a recognised risk factor for both acute and chronic respiratory illness.Areas covered: The aim of this paper was to review the epidemiology of ETS exposure and impact on respiratory health in children. We conducted a search of 3 electronic databases of publications on ETS and childhood respiratory illness from 1990–2015. Key findings were that up to 70% of children are exposed to ETS globally, but under-reporting may mask the true prevalence. Maternal smoking and ETS exposure influence infant lung development and are associated with childhood upper and lower respiratory tract infection, wheezing or asthma. Further, exposure to ETS is associated with more severe respiratory disease. ETS exposure reduces lung function early in life, establishing an increased lifelong risk of poor lung health.Expert commentary: Urgent and effective strategies are needed to decrease ETS exposure in young children to improve child and long-term lung health in adults especially in low and middle income countries where ETS exposure is increasing.

show abstract

Section: Resultsmentioning

confidence: 99%

The association between environmental tobacco smoke exposure and childhood respiratory disease: a review

Vanker

Gie

Zar

2017

Expert Review of Respiratory Medicine

151

View full text Add to dashboard Cite

show abstract

“…Cockroaches produce several allergens that induce sensitization, and exposure to high levels of cockroach allergens at home is a major risk factor for symptoms in sensitized individuals [68]. Recent data suggest that cockroach allergen may be a most relevant urban allergen exposure and may be related to asthma severity [69]. Indoor allergen exposure in inner-city areas has been of particular interest given that patients living in urban areas have increased asthma severity, decreased asthma control, and greater health care use [70].…”

Section: Cockroach Allergens Sensitization and Severe Asthmamentioning

confidence: 99%

Is allergic sensitization relevant in severe asthma? Which allergens may be culprits?

Lombardi

Savi

Ridolo

et al. 2017

World Allergy Organization Journal

View full text Add to dashboard Cite

Severe asthma is a major health concern. The allergic (IgE-mediated) form of asthma is well known from a pathogenic viewpoint. We searched the available literature to identify which allergens are most frequently associated with severe, refractory or life threatening asthma. According to the results, molds, pet dander, cockroach and ragweed were more frequently responsible for severe asthma. Thunderstorm asthma, in addition, represents a special association between allergic sensitization and an external climatic factor. A detailed knowledge of the most harmful allergens is mandatory for an appropriate diagnostic and preventive approach.

show abstract

“…Ahluwalia et al observed that sensitization/exposure to both mouse and cockroach was associated with worse asthma in an inner-city community in Baltimore exposed to high levels of both allergens. However, mouse allergen appeared to be more strongly and consistently associated with poor asthma outcomes than cockroach allergen [16,17]. …”

Section: Cockroach Allergy and Inner-city Asthmamentioning

confidence: 99%

New Insights into Cockroach Allergens

Pomés

Mueller

Randall

et al. 2017

Curr Allergy Asthma Rep

View full text Add to dashboard Cite

Purpose of review This review addresses the most recent developments on cockroach allergen research in relation to allergic diseases, especially asthma. Recent findings The number of allergens relevant to cockroach allergy has recently expanded considerably up to 12 groups. New X-ray crystal structures of allergens from groups 1, 2 and 5 revealed interesting features with implications for allergen standardization, sensitization, diagnosis and therapy. Summary Cockroach allergy is strongly associated with asthma particularly among children and young adults living in inner-city environments, posing challenges for disease control. Environmental interventions targeted at reducing cockroach allergen exposure have provided conflicting results. Immunotherapy may be a way to modify the natural history of cockroach allergy and decrease symptoms and asthma severity among sensitized and exposed individuals. The new information on cockroach allergens is important for the assessment of allergen markers of exposure and disease, and for the design of immunotherapy trials.

show abstract

Difficult-to-control asthma

Cited by 48 publications

References 44 publications

The association between environmental tobacco smoke exposure and childhood respiratory disease: a review

The association between environmental tobacco smoke exposure and childhood respiratory disease: a review

Is allergic sensitization relevant in severe asthma? Which allergens may be culprits?

New Insights into Cockroach Allergens

Contact Info

Product

Resources

About