Difficulties in activities of daily living are associated with stigma in patients with Parkinson’s disease who are candidates for deep brain stimulation

Silva, Antônio Geraldo da; Leal, Vanessa P.; Silva, Paulo Ricardo da; Freitas, Fernando Cini; Linhares, Marcelo Neves; Walz, Roger; Malloy-Diniz, Leandro Fernandes; Diaz, Alexandre Paim; Palha, António Pacheco

doi:10.1590/1516-4446-2018-0333

Cited by 18 publications

(7 citation statements)

References 33 publications

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“…The results were also inconsistent: depression has been reported to correlate with self-stigma in four studies (Schrag et al, 2001;Oguru et al, 2010;Ma et al, 2016;Salazar et al, 2019) but not in another three studies (Chapuis et al, 2005;Wu et al, 2014;da Silva et al, 2020). Younger age has been reported to correlate with self-stigma in two studies (Wu et al, 2014;Salazar et al, 2019) but not in another five studies (Schrag et al, 2001;Chapuis et al, 2005;Oguru et al, 2010;Ma et al, 2016;da Silva et al, 2020), while apathy, difficulties in ADL, non-motor symptoms, H&Y stage, marital status, biphasic dyskinesia, morning akinesia, end-ofdose fluctuations, and unpredictable offs have been reported to correlate with self-stigma only in a single study (Chapuis et al, 2005;Oguru et al, 2010;Wu et al, 2014;da Silva et al, 2020). The heterogeneous results might partially ascribe to the different cultural backgrounds as self-stigma originates in the social context (Major and O'Brien, 2005).…”

Section: Discussionmentioning

confidence: 93%

“…Self-stigma in neuropsychiatric diseases may lead to harmful consequences, such as social isolation, delayed search for medical help, non-adherence to treatment, and increased suicide rates (Corrigan, 2004;Schomerus et al, 2015). Previous studies have shown that self-stigma is a key determinant of health-related quality of life in PD (Ma et al, 2016), and it is associated with difficulties in activities of daily living (ADL) (da Silva et al, 2020) and high burden for caregivers (Tan et al, 2019) in patients with PD. Thus, studying the determinants of self-stigma in PD might help to intervene and reduce it.…”

Section: Introductionmentioning

confidence: 99%

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Self-Stigma in Parkinson's Disease: A 3-Year Prospective Cohort Study

Lin

Wei

et al. 2022

Front. Aging Neurosci.

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PurposeSelf-stigma is common in patients with Parkinson's disease (PD) and may lead to social isolation and delayed search for medical help. We conducted a 3-year prospective longitudinal study to investigate the development and evolution of self-stigma in patients with early stage PD and to explore the associated and predictive factors of self-stigma in PD.MethodA total of 224 patients with early stage PD (disease duration <3 years) were enrolled at baseline and followed up annually for 3 consecutive years. Self-stigma was assessed by the stigma subscale of the Parkinson's Disease Questionnaire (items 23–26). The generalized estimating equation model was used to investigate the associated factors of self-stigma over 3 years, and the binary logistic model was used to explore the predictors of self-stigma in patients with PD without self-stigma at baseline.ResultsThe prevalence of self-stigma decreased from 58.0% at baseline to 49.2% after 3 years. The Hamilton Depression Rating Scale (HDRS) score was the only associated factor [B: 0.160 (1.106–0.214), P < 0.001] of self-stigma over 3 years and the only predictor [OR: 1.252 (1.044–1.502), P = 0.015] of the onset of self-stigma.ConclusionSelf-stigma is very common in PD, but its prevalence tends to decrease as the disease progresses. Depression was the only associated and predictive factor of self-stigma in PD and could be an effective target of alleviating self-stigma.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Self-Stigma in Parkinson's Disease: A 3-Year Prospective Cohort Study

Lin

Wei

et al. 2022

Front. Aging Neurosci.

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“…The burden of unemployment from EOPD goes beyond a financial cost, including social isolation, feelings of futility, lack of purpose and self‐esteem, and lack of daily structure. Many patients with PD are most bothered by the perception that others might have of their impairment than by their impairment itself 141,142 . This higher level of stigma in patients with EOPD 17,143 seems to stem essentially from dysarthria, tremor, dyskinesia, and impact of the motor symptoms on activities of daily living such as eating and washing 144 and can manifest as a reluctance to seek help and ask for adjustments at work, which in turn decreases the chances of staying employed.…”

Section: Impact Of Pd On Employment and Social Perceptionmentioning

confidence: 99%

Age Cutoff for Early‐Onset Parkinson's Disease: Recommendations from the International Parkinson and Movement Disorder Society Task Force on Early Onset Parkinson's Disease

Mehanna

Fleisher

Post

et al. 2022

Movement Disord Clin Pract

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Background Early‐onset Parkinson's disease (EOPD)/young‐onset Parkinson's disease (YOPD) is defined as Parkinson's disease (PD) with an age at onset (AAO) after age 21 years but before the usual AAO for PD. Consensus is lacking, and the reported maximal age for EOPD/YOPD has varied from 40 to 60 years, leading to a lack of uniformity in published studies and difficulty in harmonization of data. EOPD and YOPD have both been used in the literature, somewhat interchangeably. Objective To define the nomenclature and AAO cutoff for EOPD/YOPD. Methods An extensive review of the literature and task force meetings were conducted. Conclusions were reached by consensus. Results First, the literature has seen a shift from the use of YOPD toward EOPD. This seems motivated by an attempt to avoid age‐related stigmatization of patients. Second, in defining EOPD, 56% of the countries use 50 or 51 years as the cutoff age. Third, the majority of international genetic studies in PD use an age cutoff of younger than 50 years to define EOPD. Fourth, many studies suggest that changes in the estrogen level can affect the predisposition to develop PD, making the average age at menopause of 50 years an important factor to consider when defining EOPD. Fifth, considering the differential impact of the AAO of PD on professional and social life, using 50 years as the upper cutoff for the definition of EOPD seems reasonable. Conclusions This task force recommends the use of EOPD rather than YOPD. It defines EOPD as PD with AAO after 21 years but before 50 years.

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“…Meanwhile, invisible stigma is the realization of a self with PD, a form of disability, which attested to the mounting isolation (11). Recently, a few studies revealed that difficulties in activities of daily living, younger age, and higher depression scores were the significant predictors of stigma (13,14). However, relative studies are limited in China.…”

Section: Introductionmentioning

confidence: 99%

Stigma and Associated Correlates of Elderly Patients With Parkinson's Disease

Hou¹,

Mao²,

Hou³

et al. 2021

Front. Psychiatry

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Background: Stigmatizing experiences is common in Parkinson's disease (PD) and appears to provide a negative contribution to the quality of life. Our aim of this study was to investigate the extent of stigma and its predictive factors in patients with PD from our hospital in Shanghai, China.Methods: In 276 individuals with PD (135 women and 141 men), stigma was measured by the 24-item Stigma Scale for Chronic Illness (SSCI). Multivariate linear regression model was used to assess predictors of stigma including demographics (age and gender), disease duration, stage (Hoehn and Yahr Scale), motor function (Unified Parkinson's Disease Rating Scale Part 3, UPDRS-III), non-motor symptoms (Non-Motor Symptoms Scale, NMSS), cognitive level (Mini-Mental State Examination, MMSE), as well as anxiety (Hamilton Anxiety Rating Scale, HAM-A) and depressive disorders (Hamilton Depression Rating Scale, HAM-D-24).Results: The total score of SSCI was 49.9 ± 14.3, and 48.5% of the patients checked “rarely” to “sometimes.” For the total sample, the full model accounted for 47.8% of the variance in stigma (P < 0.05). Higher UPDRS-III scores, longer course of disease, younger age, tremor-dominant subtype, and higher depression scores were significantly associated with stigma among individuals with PD.Conclusion: Our finding suggested a mild-to-moderate level of stigma in patients with PD. Tremor-dominant subtype, longer course of disease, younger age, severe motor symptoms, and depression are the predictors of stigma in PD.

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Difficulties in activities of daily living are associated with stigma in patients with Parkinson’s disease who are candidates for deep brain stimulation

Cited by 18 publications

References 33 publications

Self-Stigma in Parkinson's Disease: A 3-Year Prospective Cohort Study

Self-Stigma in Parkinson's Disease: A 3-Year Prospective Cohort Study

Age Cutoff for Early‐Onset Parkinson's Disease: Recommendations from the International Parkinson and Movement Disorder Society Task Force on Early Onset Parkinson's Disease

Stigma and Associated Correlates of Elderly Patients With Parkinson's Disease

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