The present study reports a case of human identification using smile photographs and anthropological exams. In 2011, an unknown cadaver was found near to an uninhabited region in the state of Goias, Brazil. In the absence of ante-mortem records, a post-mortem anthropological profile was built, narrowing police lists of missing persons. Potential relatives of the victim were found. However, no medical or dental records of the victim were detected. Only two smile photographs were retrieved from the family belongings. Dental identifiers from the photographs and from the cadaveric exam were matched, converging for a positive human identification. Based on that, the present case illustrates the practical value of combining comparative and reconstructive approaches for human identification.