Difficulties on the access to innovative targeted therapies for lung cancer in Spain

Abstract

Purpose Spanish Lung Cancer Group (SLCG) conducted a review to analyze the barriers to access to innovative targeted therapies for non-small cell lung cancer (NSCLC) in clinical practice in Spain. Methods Review all relevant content published on websites of European Commission, European Medicines Agency, and Spanish Agency of Medicines and Medical Products regarding the authorization and access to oncology treatments. Results More than 20 targeted therapies are available to treat different molecular alterations in patients with NSCLC. European Commission has approved treatments for genomic alterations involving the following genes: ALK, RET, ROS1, EGFR, BRAF, NTRK, KRAS, MET. However, the availability of these therapies in Spain is not complete, as innovative treatments are not reimbursed or funded late, with only five of these alterations currently covered by National Health System. Conclusion SLCG considers imperative to improve the access in Spain to innovative treatments for NSCLC to reduce inequity across European countries.

Healthcare Resource Utilization and Associated Costs among Patients with Advanced Non-Small-Cell Lung Cancer Receiving Chemotherapy or Immunotherapy in Spain: A Single-Center, Real-World, Exploratory Study

“…On the one hand, the high economic burden caused by AEs due to systemic CT compared with IT, in terms of the increased HCRU and hospitalization-associated costs, has rarely been assessed in either clinical trials [ 26 ] or real-world studies [ 27 ]. On the other hand, due to the great heterogeneity in the access to cancer drugs, the diversity of prescription criteria, and the differences in pricing and reimbursement policies among different EU countries, and even within the same country, the conduction of large, real-world, multicenter studies could be hampered [ 28 , 29 , 30 , 31 ].…”