Difficulties with vitamin D nutrition research: objective targets of adequacy, and assays for 25-hydroxyvitamin D

Vieth, Reinhold; Carter, G

doi:10.1038/sj.ejcn.1601145

Cited by 27 publications

(20 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Comparisons among 25(OH)D levels from different places are reasonable now, so long as the same methods are used for measuring 25(OH)D, and the laboratories take part in the DEQAS proficiency survey (Vieth & Carter, 2001). We do take part in the survey and our 25(OH)D results for shared samples match those of laboratories elsewhere.…”

Section: Vitamin D Insufficiency R Vieth Et Almentioning

confidence: 54%

Wintertime vitamin D insufficiency is common in young Canadian women, and their vitamin D intake does not prevent it

et al. 2001

Self Cite

View full text Add to dashboard Cite

Objective: We asked whether women self-reporting the recommended consumption of vitamin D from milk and multivitamins would be less likely to have low wintertime 25-hydroxyvitamin D (25(OH)D) levels. Methods: This cross-sectional study enlisted at least 42 young women each month (age 18 -35 y, 796 women total) through one year. We measured serum 25(OH)D and administered a lifestyle and diet questionnaire. Results: Over the whole year, prevalence of low 25(OH)D ( < 40 nmol=l) was higher in non-white, non-black subjects (25.6% of 82 women) than in the white women (14.8% of 702 white women, P < 0.

show abstract

Section: Vitamin D Insufficiency R Vieth Et Almentioning

confidence: 54%

Wintertime vitamin D insufficiency is common in young Canadian women, and their vitamin D intake does not prevent it

et al. 2001

Self Cite

View full text Add to dashboard Cite

show abstract

“…Samples were analyzed for levels of 25OHD, total calcium, inorganic phosphorus, and alkaline phosphatase (elevated levels indicate vitamin D insufficiency 14 ). 25OHD, a reliable measure of overall vitamin D status, 23 was assessed via radioimmunoassay by using a DiaSorin kit (DiaSorin, Inc, Stillwater, MN). 25OHD concentrations ,35 nmol/L were considered deficient and those $75 nmol/L were optimal.…”

Section: Methodsmentioning

confidence: 99%

Prenatal Vitamin D and Dental Caries in Infants

Lavelle²,

et al. 2014

View full text Add to dashboard Cite

WHAT'S KNOWN ON THIS SUBJECT: Many young children are at risk for caries, which is the most common chronic disease of childhood. As primary teeth begin to develop in utero, prenatal influences are believed to affect the integrity of enamel and subsequent resistance to decay. WHAT THIS STUDY ADDS:This study shows, for the first time, that maternal prenatal 25-hydroxyvitamin D levels may have an influence on the primary dentition and the development of early childhood caries. Specifically, lower levels are associated with increased risk of caries in infants. abstract OBJECTIVES: Inadequate maternal vitamin D (assessed by using 25-hydroxyvitamin D [25OHD]) levels during pregnancy may affect tooth calcification, predisposing enamel hypoplasia and early childhood caries (ECC). The purpose of this study was to determine the relationship between prenatal 25OHD concentrations and dental caries among offspring during the first year of life.METHODS: This prospective cohort study recruited expectant mothers from an economically disadvantaged urban area. A prenatal questionnaire was completed and serum sample drawn for 25OHD. Dental examinations were completed at 1 year of age while the parent/ caregiver completed a questionnaire. The examiner was blinded to mothers' 25OHD levels. A P value # .05 was considered significant. RESULTS:Overall, 207 women were enrolled (mean age: 19 6 5 years). The mean 25OHD level was 48 6 24 nmol/L, and 33% had deficient levels. Enamel hypoplasia was identified in 22% of infants; 23% had cavitated ECC, and 36% had ECC when white spot lesions were included in the assessment. Mothers of children with ECC had significantly lower 25OHD levels than those whose children were caries-free (41 6 20 vs 52 6 27 nmol/L; P = .05). Univariate Poisson regression analysis for the amount of untreated decay revealed an inverse relationship with maternal 25OHD. Logistic regression revealed that enamel hypoplasia (P , .001), infant age (P = .002), and lower prenatal 25OHD levels (P = .02) were significantly associated with ECC.CONCLUSIONS: This study found that maternal prenatal 25OHD levels may have an influence on the primary dentition and the development of ECC. Pediatrics 2014;133:e1277-e1284

show abstract

“…Serum 25-hydroxyvitamin D is the biomarker most commonly used to assess vitamin D status. The most appropriate thresholds for determining vitamin D status are an issue of debate (39)(40)(41) . The focus of this argument is on determining the optimal level for health as opposed to the minimum level to prevent deficiency and severe bone disease such as osteomalacia and rickets.…”

Section: Vitamin D Insufficiency In Crohn's Diseasementioning

confidence: 99%

Session 3: Joint Nutrition Society and Irish Nutrition and Dietetic Institute Symposium on ‘Nutrition and autoimmune disease’ Nutrition in Crohn's disease

O’Sullivan

2009

Proc. Nutr. Soc.

View full text Add to dashboard Cite

The exact aetiology of Crohn's disease remains unknown. The consensus is that the disease results from a complex interaction between genes, immunity and environmental factors. Diet is attractive, in theory, as an environmental risk factor in the aetiology of the disease. The epidemiological data, often impeded by methodological issues, have failed to confirm a direct link between pre-diet illness and the development of Crohn's disease. Once diagnosed, however, nutrition has an important role in disease management. Among the nutritional issues are malnutrition, weight loss and suboptimal nutritional status; these outcomes may be present at any stage of the disease but are likely to be overt during acute illness and hospitalisation. Malnutrition has been identified in approximately 40% of hospital admissions with Crohn's disease and is associated with higher mortality, longer hospital stays and higher healthcare costs. Patients in remission may indeed be overweight and appear to be influenced by the general population trends toward overweight and obesity. Irrespective of BMI, patients are at risk of micronutrient deficiencies. Vitamin D deficiency, for example, is common in Crohn's disease and has important implications for bone health. Moreover, newer evidence suggests that vitamin D has potential anti-inflammatory effects. Dietary approaches, in the form of enteral nutrition, have previously been shown to reduce inflammation and treat the active disease. Current guidelines now recommend that corticosteroids are more effective than enteral nutrition for treating adults. Enteral nutrition has important growth and developmental benefits and continues to be a recommended therapy for children with Crohn's disease.

show abstract

Difficulties with vitamin D nutrition research: objective targets of adequacy, and assays for 25-hydroxyvitamin D

Cited by 27 publications

References 7 publications

Wintertime vitamin D insufficiency is common in young Canadian women, and their vitamin D intake does not prevent it

Wintertime vitamin D insufficiency is common in young Canadian women, and their vitamin D intake does not prevent it

Prenatal Vitamin D and Dental Caries in Infants

Session 3: Joint Nutrition Society and Irish Nutrition and Dietetic Institute Symposium on ‘Nutrition and autoimmune disease’ Nutrition in Crohn's disease

Contact Info

Product

Resources

About