Diffraction-based assay for detecting multiple analytes

Goh, Jane Betty; Loo, Richard W.; McAloney, Richard; Goh, M. Cynthia

doi:10.1007/s00216-002-1478-5

Cited by 53 publications

(30 citation statements)

References 3 publications

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“…Such structures have found applications in biosensing, with the diffracted light studied as a function of the analyte concentration [11]. The analyte is detected by monitoring the diffraction signal intensity, which depends quadratically on the grating optical thickness.…”

Section: Diffraction Enhancementmentioning

confidence: 99%

Enhancing light-matter interaction via Bloch surface waves for biosensing applications

Liscidini

Galli

Patrini

et al. 2009

2009 11th International Conference on Transparent Optical Networks

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We present two different configurations for the detection of Bloch surface waves in silicon nitride multilayers: attenuated total reflectance and photoluminescence measurements. In the first case, we measured a 50-fold enhancement of the diffraction signal by a protein grating printed on the multilayer when the incident light beam is coupled to the surface waves. In the second case, we observe a significant modification of the spontaneous emission by a monolayer of rhodamine molecules bonded to the photonic crystal surface. These results may found application in the field of optical sensors and biosensors.

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Section: Diffraction Enhancementmentioning

confidence: 99%

Enhancing light-matter interaction via Bloch surface waves for biosensing applications

Liscidini

Galli

Patrini

et al. 2009

2009 11th International Conference on Transparent Optical Networks

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“…[2][3][4][5] Among the large numbers of devices that can be found in literature, surface plasmon ͑SP͒ sensors are probably the most studied and utilized. 15 Recently, Yu et al have proposed the combination of SP and diffraction based sensors to increase the diffraction efficiency by exploiting the high field localization in SP modes. [6][7][8] Bloch surface waves ͑BSWs͒ are evanescent waves that propagate at the surface of a semiinfinite periodic dielectric stack.…”

Section: Enhancement Of Diffraction For Biosensing Applications Via Bmentioning

confidence: 99%

Enhancement of diffraction for biosensing applications via Bloch surface waves

Liscidini

Sipe

2007

Applied Physics Letters

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We propose a biosensor based on the diffraction of Bloch surface waves (BSWs) in periodic dielectric stacks. Significant enhancement of diffraction efficiency by a biomolecule grating placed on the multilayer is predicted when a BSW is excited through a prism in the Kretschmann configuration. Numerical calculations for BSW in a Si∕SiO2 dielectric stack show an increase of diffraction intensity up to three orders of magnitude with respect to the case of surface plasmon wave enhancement. The mechanism that leads to large field confinement and the absence of absorption losses in the dielectric system make this solution flexible and suitable to different grating periods.

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“…For instance, living cells (Morhard et al 2000) and large biomolecules (Tsay et al 1991;St. John et al 1998;Goh et al 2002) have been detected with fairly good sensitivity employing few tens of micron sized diffraction gratings. The binding ability of various analytes with the molecules of interest has been accessed using in situ assembled diffraction gratings where thickness variation of the grating and changes in refractive index were studied (Goh et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Pd grating obtained by direct micromolding for use in high resolution optical diffraction based sensing

Gupta

2012

Bull Mater Sci

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Pd grating patterns have been fabricated using the process of micromolding in capillary employing a Pd alkanethiolate precursor, which could be converted to metal in situ by thermolysis. Thus generated Pd grating were uniform in width (∼950 nm) and spacing (∼450 nm) over millimeter square areas on glass substrates. Importantly, the pattern when used as an optical grating produced a diffraction pattern with a high resolution (>2000); the intensities of widely separated (diffraction angle, ∼26•8 •) diffracted spots could be measured using a simple photodiode. By varying the concentration of Pd precursor (2 mM to 25 mM), thickness of the resulting gratings could be adjusted in the range of ∼15-115 nm. By adjusting the grating parameters optimally, a maximum diffraction efficiency of 36% has been achieved. Thus fabricated Pd grating was used as seed catalyst to deposit Cu by electroless plating. The Cu deposition process has also been monitored by employing AFM, SEM and EDS analysis. The diffraction efficiency values corroborate well with the changes in the grating thickness due to Cu deposition. The grating structures presented can be reproducibly fabricated for rapidly emerging optical diffraction based sensing applications. This has been demonstrated in the case of aqueous Cu 2+ by depositing the latter electrolessly on Pd.

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Diffraction-based assay for detecting multiple analytes

Cited by 53 publications

References 3 publications

Enhancing light-matter interaction via Bloch surface waves for biosensing applications

Enhancing light-matter interaction via Bloch surface waves for biosensing applications

Enhancement of diffraction for biosensing applications via Bloch surface waves

Pd grating obtained by direct micromolding for use in high resolution optical diffraction based sensing

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