Diffuse 18F-FDG uptake throughout the spinal cord in the acute phase of Neuromyelitis Optica Spectrum disorder

Higashiyama, Akira; Komori, Tsuyoshi; Inada, Yuji; Nishizawa, Masahiko; Nakajima, Hideto; Narumi, Yasuo

doi:10.1007/s00259-017-3735-z

Cited by 5 publications

(1 citation statement)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In AQP4-IgG-positive optic neuromyelitis, the loss and dysfunction of astrocytes lead to the secondary loss of oligodendrocytes and neurons [101]. In the relevant case reports, more cases used 18 F-FDG-PET to represent the astrocyte injury and hypermetabolic state of the disease [102,103], which is not specific enough to reflect the pathological characteristics. The same examples, such as autoimmune GFAP astrocytopathy [104] and Alexandria disease [105], are caused by astrocyte changes.…”

Section: Other Neurological Disordersmentioning

confidence: 99%

PET imaging of reactive astrocytes in neurological disorders

Liu

Jiang

Qin

et al. 2021

Eur J Nucl Med Mol Imaging

View full text Add to dashboard Cite

The reactive astrocytes manifest molecular, structural, and functional remodeling in injury, infection, or diseases of the CNS, which play a critical role in the pathological mechanism of neurological diseases. A growing need exists for dependable approach to better characterize the activation of astrocyte in vivo. As an advanced molecular imaging technology, positron emission tomography (PET) has the potential for visualizing biological activities at the cellular levels. In the review, we summarized the PET visualization strategies for reactive astrocytes and discussed the applications of astrocyte PET imaging in neurological diseases. Future studies are needed to pay more attention to the development of specific imaging agents for astrocytes and further improve our exploration of reactive astrocytes in various diseases.

show abstract