Diffuse and Localized Nerve Fiber Loss in Glaucoma

Airaksinen, P. Juhani; Drance, Stephen M.; Douglas, Gordon R.; Mawson, Daniel K.; Nieminen, Heikki J.

doi:10.1016/0002-9394(84)90242-3

Cited by 226 publications

(134 citation statements)

References 9 publications

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“…21,72,99,100,106,112,115,[154][155][156][157][158][159][160][161][162][163][164][165][166][167][168][169][170] Twenty studies were representative of a glaucoma suspect population referred from primary care, of which eight were cohort studies 22,171-177 and 12 were case-control studies. [178][179][180][181][182][183][184][185][186][187][188][189][190][191] …”

Section: Accuracymentioning

confidence: 99%

“…Thirteen studies took place in the USA, 22,158,159,162,166,168,170,172,175,181,[187][188][189] nine in the UK, 21,164,176,177,180,182,186,190,191 four in Australia, 115,157,163,173 two each in Italy, 106,174 The Netherlands, 169,183 Spain 99,179 and Sweden, 100,171 one each in Belgium, 155 Canada, 156 Greece, 112 India 161 and Norway, 154 and one in Canada and Finland. 178 Twenty-six studies gave details of the gender of their participants, 51% of whom were women. 21 164,165 No studies of GDx VCC, OCT, RTA, SWAP, MDP or Tonopen met the inclusion criteria in terms of reporting of test accuracy outcomes.…”

Section: Characteristics Of Studiesmentioning

confidence: 99%

“…178,188,189 Figure 20 summarises the quality assessment for these studies. In two of the four studies the participants were considered to be representative of a screening 167 or diagnostic 188 setting.…”

Section: Rnfl Photographymentioning

confidence: 99%

“…Three studies were judged to be free from both partial and differential verification bias. 178,188,189 In one study both the index test and the reference standard test were interpreted without knowledge of each other's results. 178 No study met all the criteria specified for higher quality studies.…”

Section: Rnfl Photographymentioning

confidence: 99%

See 3 more Smart Citations

The clinical effectiveness and cost-effectiveness of screening for open angle glaucoma: a systematic review and economic evaluation

Burr¹,

Mowatt²,

Hernández³

et al. 2007

Health Technol Assess

330

380

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Section: Accuracymentioning

confidence: 99%

Section: Characteristics Of Studiesmentioning

confidence: 99%

Section: Rnfl Photographymentioning

confidence: 99%

Section: Rnfl Photographymentioning

confidence: 99%

See 2 more Smart Citations

The clinical effectiveness and cost-effectiveness of screening for open angle glaucoma: a systematic review and economic evaluation

Burr¹,

Mowatt²,

Hernández³

et al. 2007

Health Technol Assess

330

380

View full text Add to dashboard Cite

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“…Moreover, in the retina the axons are spread out in a thin layer and, therefore, the examination of the RNFL should logically provide more information of the minor sectorial losses of axons than the evaluation of the optic nerve head where axons are packed up closely. The evaluation of the RNFL using black-andwhite photographs has been found to be a sensitive and useful method with good reproducibility (Airaksinen et al 1984;Quigley 1986;Quigley et al 1993). The present study was carried out to test the OCT's capability to record retinal nerve fiber layer defects detectable on monochromatic fundus images.…”

mentioning

confidence: 99%

Optical coherence tomography and localized defects of the retinal nerve fiber layer

Teesalu

Tuulonen

Airaksinen

2000

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To test the capability of the optical coherence tomography (OCT) to demonstrate and quantitate retinal nerve fiber layer (RNFL) defects. Methods: The authors examined 6 eyes of 6 chronic open angle glaucoma patients with the OCT. The patients had abnormal Humphrey 30-2 visual fields which corresponded to RNFL defects visible in monochromatic fundus images taken with a digital imaging system. The RNFL images were used for directing the OCT scans to areas where most information was believed to be obtainable. Several linear scans of different lengths across healthy and abnormal RNFL regions were made. Results: When the OCT images were compared to RNFL photographs, the defective areas showed reduced backscattering with the OCT, being distinctly different from the adjacent normal RNFL. Except for one case the RNFL thickness values were smaller in the areas of abnormal appearance compared to areas of normal appearance. Conclusion: This preliminary study suggests that the OCT examination results of the RNFL are in good agreement with the RNFL appearance in monochromatic fundus images.

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The Retinal Nerve Fiber Layer Thickness in Ocular Hypertensive, Normal, and Glaucomatous Eyes With Optical Coherence Tomography

Bowd

Weinreb²,

Williams³

et al. 2000

Arch Ophthalmol

268

159

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To quantitatively assess and compare the thickness of the retinal nerve fiber layer (RNFL) in ocular hypertensive eyes with normal and glaucomatous eyes using the Optical Coherence Tomograph (OCT 2000, software version A4X1; Humphrey Instruments, San Leandro, Calif). Methods:The mean RNFL thickness of ocular hypertensive (n = 28) eyes was compared with age-matched normal (n = 30) and glaucomatous (n = 29) eyes. Subject eyes were classified into diagnostic groups based on intraocular pressure, stereoscopic disc photographs, and standard automated perimetry. Three circular scans were obtained for each eye at a diameter of 3.4 mm around the optic disc. In each eye, average RNFL thickness measurements were obtained in temporal, superior, nasal, and inferior quadrants. A single index of average RNFL thickness throughout 360°also was obtained.Results: Mean (95% confidence interval) RNFL was significantly thinner in ocular hypertensive eyes than in normal eyes, 72.8 µm (66.4-78.1 µm) and 85.8 µm (80.2-91.7 µm), respectively. More specifically, RNFL was significantly thinner in ocular hypertensive eyes than in normal eyes in the inferior quadrant, 84.8 µm (75.6-94.0 µm) vs 107.6 µm (99.3-115.9 µm); and in the nasal quadrant, 44.1 µm (37.5-51.7 µm) vs 61.8 µm (53.0-65.6 µm). Retinal nerve fiber layer was significantly thinner in glaucomatous eyes than in ocular hypertensive and normal eyes throughout 360°and in all quadrants. Conclusion:These findings suggest that quantitative differences in RNFL thickness exist between age-matched ocular hypertensive, normal, and glaucomatous eyes.

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Diffuse and Localized Nerve Fiber Loss in Glaucoma

Cited by 226 publications

References 9 publications

The clinical effectiveness and cost-effectiveness of screening for open angle glaucoma: a systematic review and economic evaluation

The clinical effectiveness and cost-effectiveness of screening for open angle glaucoma: a systematic review and economic evaluation

Optical coherence tomography and localized defects of the retinal nerve fiber layer

The Retinal Nerve Fiber Layer Thickness in Ocular Hypertensive, Normal, and Glaucomatous Eyes With Optical Coherence Tomography

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