Diffuse cavitary lung lesions

Grunzke, Mindy L.; Hayes, Kari; Bourland, W. Lee; Garrington, Timothy P.

doi:10.1007/s00247-009-1410-7

Cited by 9 publications

(9 citation statements)

References 6 publications

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“…Pediatric cases of PPHL seem to be extremely rare; within the last 10 years only a few reports have been published. These reports reflect the scope of clinical signs and symptoms: from fever, weight loss and the suggestion of tuberculosis to non-resolving pneumonia diffuse and cavitary lung lesions [ 15 , 18 - 20 ]. A misleading clinical manifestation resulted in delayed diagnosis in all reported patients, as well as in a patient presented in this report.…”

Section: Discussionmentioning

confidence: 77%

“…If assisted by lymphadenopathy and/or anterior mediastinal tumor, lymphoma should be always suspected. The diagnosis is based on imaging studies which reveal lung parenchymal lesions: parenchymal pulmonary masses (nodules) and pulmonary cavitations; Hodgkin lymphoma should always be considered in the differential diagnosis of cavitary pulmonary lesions, especially those refractory to treatment [ 15 , 16 ]. Lesions are unspecific; thus histology is required to confirm the final diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…Existing literature data and our observations seem to indicate that in children with PPHL the diagnosis is significantly delayed. The delay, however, does not influence the prognosis in these patients [ 15 , 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

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Pediatric pulmonary hodgkin lymphoma: Analysis of 10 years data from a single center

et al. 2010

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Several reports indicate that lungs are the extralymphatic site most commonly affected in patients with Hodgkin lymphoma; however, the data in children are rather limited. This retrospective study aimed to assess the frequency, clinical picture, and the impact on prognosis in children with pulmonary Hodgkin lymphoma, who were diagnosed and treated in a single center during a 10-year period. Pulmonary lesions related to HL: nodules and parenchymal infiltrates with cavitations were found in 3 of 32 (9.4%) patients; in 2 cases these were found as the concomitant manifestation whereas in 1 case as the solitary form (Primary Pulmonary Hodgkin Lymphoma). B-DOPA and MVPP chemotherapy combined with mediastinal and pulmonary irradiation resulted in sustained remissions in all 3 patients, lasting 3, 7, and 64 months, respectively. Lung involvement occurs in up to 10% of children with Hodgkin lymphoma. Primary pulmonary Hodgkin lymphoma is a rare and atypical form of Hodgkin lymphoma; thus is associated with delayed diagnosis which does not seem to affect prognosis. It should be suspected in a child with non-resolving pneumonia and pulmonary parenchymal infiltrates with cavitations.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

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Pediatric pulmonary hodgkin lymphoma: Analysis of 10 years data from a single center

et al. 2010

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“…This unique morphology is remarkable. While the current literature describes Auer rod-like inclusions in single cases of different forms of myeloma [1,2,3,4,5], this is, to the best of our knowledge, the first report on the concomitant appearance with enlarged highly atypical "owl-eyed" plasma cells in a patient suffering from κ-type light chain myeloma.…”

Section: To the Editormentioning

confidence: 83%

Atypical Radiologic Image Characterized by Cavitary Lun Lesions In a Case With Hodgkin Lymphoma

Büyükşimşek¹,

Paydaş²,

Gümürdülü³

et al. 2018

Tjh

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A 30-year-old woman was admitted to the hospital with a lump in her neck. She had no B symptoms (fever, night sweats, and weight loss) and a biopsy showed Hodgkin lymphoma (HL) of the classical type. Positron emission tomography/computed tomography (PET/CT) showed cervical and mediastinal lymph nodes of 1.5-3 cm in diameter and an invasive left parasternal mass of 4x2.5 cm.Three cycles of ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) were given and less than partial response (PR) was detected by PET/CT. Salvage chemotherapy and autologous stem cell transplantation (ASCT) were planned and 2 cycles of the DHAP regimen (cisplatin, dexamethasone, cytosine) were given. PR was detected by PET-CT, but she rejected the ASCT. Local radiotherapy was given for the residual tumor. After radiation there was no evidence of a tumor upon PET/CT imaging. One and a half years after the end of radiation she was admitted with cough, dyspnea, sputum, and fever.Thoracic CT showed cavitary lesions in the parenchyma of both lungs and atelectasis in the left lingula (Figure 1). The patient was counseled in the department of chest diseases; radiation pneumonia was not considered. The angiotensin-converting enzyme level for sarcoidosis was normal. Bronchoscopic examination, lavage, and biopsy were done. Fungal tests were found to be negative. The cavitary lesion was preferred for biopsy. The biopsy showed HL of the classical type ( Figure 2) and CD30 was positive (Figure 3). A QuantiFERON test of the blood sample and tuberculosis polymerase chain reaction from biopsy material were negative.

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“…We appreciate the comments of Marchiori et al [1] and their recommendation for inclusion of benign neoplasm in the differential diagnosis of multiple cavitary lung lesions. Our case illustrates that coming to a correct diagnosis in this situation can be difficult [2]. Considering all diagnostic possibilities, including malignancy, early in the process it is important to allow steps to be taken to make a specific diagnosis and avoid delays in the initiation of the appropriate therapy.…”

Section: Sirmentioning

confidence: 93%