Diffuse choroidal hemangioma associated with exudative retinal detachment in a Sturge–Weber syndrome case: Photodynamic therapy and intravitreous bevacizumab

Sturge–Weber syndrome – A case report

“…7 Glaucoma, exudative retinal detachment (ERD) and heterochromia iridis may be present in 30e70% as ophthalmic manifestation. 8 In the present case the authors report the subscleral hemangiomas under ophthalmoscopy.…”

“…2 Photodynamic therapy and intravitreous bevacizumab is an upcoming treatment modalities for diffuse choroidal hemangioma. 8 Correction of gingival enlargement can be done with gingivectomy and lasers as they have additional advantage of homeostasis and minimum damage to oral tissues. 9 In the present case treatment plan which was carried out consisted of full mouth oral prophylaxis, and extractions of grade II mobile teeth 54, 84 & 85 under local anesthesia.…”

Leveraging a Sturge-Weber Gene Discovery: An Agenda for Future Research

“…Diffuse choroidal hemangioma is treated by a number of approaches including photodynamic and radiotherapy, while local anti-VEGF therapy may also be an option based on some case reports. 33–35 Most of the published data, however, are based on case reports or small case series; therefore, evidence-based guidelines cannot be developed until results from larger, multicenter studies become available.…”

Role of Radiation Therapy for Choroidal Hemangioma: A Brief Review

“…Photodynamic therapy (laser wavelengths range of 689-692 nm at an intensity of 600 mW/cm 2 with duration of 83 seconds [50-100 J/cm 2 ], one spot or multiple partial overlying spots) with intravenous verteporfin (dose of 6 mg/m 2 ) is preferred in patients with isolated symptomatic CCH with localized RD where laser photocoagulation is ineffective [10][11][12][13]. PDT causes atrophy of hemangioma vessels that decreases the exudation thereby significantly improving the visual acuity.…”

“…The retina re-attaches completely with the resolution of macular edema after PDT. Following PDT, there is no recurrence of exudates for longer durations which preserved the visual acuity in children [12,13]. The advantage of PDT is that it protects the overlying retina without destroying its function and the retinal vessels.…”