Diffuse cutaneous leishmaniasis - A rare cutaneous presentation in an HIV-positive patient

Purohit, Hemang; Shah, Asha; Amin, Bipin; Shevkani, Manoj

doi:10.4103/0253-7184.93834

Cited by 6 publications

(6 citation statements)

References 4 publications

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“…Cutaneous manifestation of leishmaniasis in patients co‐infected with HIV is associated with clinical polymorphism and a challenging differential diagnosis, especially in nonendemic areas. Various manifestations have been reported, including papulonodular, ulcerative, infiltrative, lepromatous and diffuse, psoriasis‐like, keloid, histoid, Kaposi sarcoma‐like or dermatofibroma‐like lesions . Such lesions were mostly observed on the face, extremities and acral area .…”

Section: Discussionmentioning

confidence: 99%

Chronic generalized fibrotic skin lesions from disseminated leishmaniasis caused by Leishmania martiniquensis in two patients from northern Thailand infected with HIV

et al. 2015

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SummaryBackground Leishmaniasis is a newly emerging infection in Thailand. Most of the previous human cases have presented with the clinical features of visceral leishmaniasis and were mainly found in southern Thailand. Here we report the first two patients from northern Thailand presenting with disseminated cutaneous leishmaniasis. Objectives To determine the nature of the infection of leishmaniasis and to identify the species of parasite responsible. Methods Clinical investigations included the taking of biopsy samples and histology. Parasitological diagnosis was performed by establishment of Leishmania promastigote cultures, and identification was performed by DNA sequencing of four independent gene loci (ribosomal RNA internal transcribed spacer 1; large subunit of RNA polymerase II; heat shock protein 70; RPL23a intergenic sequence). Results Both patients were infected with HIV, and had multiple cutaneous lesions and accompanying visceral leishmaniasis. They had similar cutaneous manifestations characterized by chronic generalized fibrotic lesions, which were more prominent on traumatic areas. In both patients the parasite was identified as Leishmania martiniquensis. This is a recently described species that is distinct and only distantly related to the classical agents of cutaneous leishmaniasis in Asia (Leishmania major and Leishmania tropica) or of visceral leishmaniasis (Leishmania donovani and Leishmania infantum). Each patient responded well to therapy with intravenous amphotericin B followed by oral itraconazole. Conclusions Leishmania martiniquensis is a cause of cutaneous leishmaniasis in Thailand.

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Section: Discussionmentioning

confidence: 99%

Chronic generalized fibrotic skin lesions from disseminated leishmaniasis caused by Leishmania martiniquensis in two patients from northern Thailand infected with HIV

et al. 2015

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“…Mucosal involvement has been reported in some Indian studies. [ 1 4 ] Affection of palms and soles has not been reported in the past. Clinical features and treatment outcome of DCL coinfected with HIV as seen in previous studies is summarized in Table 1 .…”

Section: Discussionmentioning

confidence: 99%

“…It is clinically characterized by multiple (>200), atypical, widespread, infiltrated skin lesions full of parasites, which seldom ulcerate, respond poorly to standard antimonial treatment, and show frequent relapses. [ 1 2 ] Very few cases are reported in Indian[ 1 2 3 4 5 ] and Western literature. [ 6 7 ] We therefore report this case from South Rajasthan.…”

Section: Introductionmentioning

confidence: 99%

Diffuse cutaneous leishmaniasis in an immunocompromised patient resembling histoid Hansen's disease

Kumari

Balai

Gupta

et al. 2018

Indian Dermatol Online J

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“…Patient was treated with ketoconazole and rifamycin, but the patient died of treatment-related complications. [10] Soni et al . reported three cases of diffuse cutaneous and localized cutaneous leishmaniasis in HIV-infected patients which were unresponsive to parenteral and intralesional sodium stibogluconate.…”

Section: Discussionmentioning

confidence: 99%

Unusual presentation of mucocutaneous leishmaniasis in HIV-infected patient

Bains

Vedant

Gupta³

et al. 2016

Indian J Sex Transm Dis

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Leishmaniasis is caused by protozoan parasite of genus leishmania. Visceral leishmaniasis, diffuse cutaneous leishmaniasis, and atypical forms of cutaneous leishmaniasis are common in HIV-infected patients. Our patient presented with an obstructive mass in nasal cavity and was diagnosed as a case of mucocutaneous leishmaniasis. Spontaneous healing of lesions in HIV-infected patients is rare rather they are unresponsive to treatment and have frequent relapses, especially in patients with low CD4 count. However, in our patient, the lesion improved significantly after 2 months of highly active antiretroviral therapy and co-trimoxazole prophylaxis.

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Diffuse cutaneous leishmaniasis - A rare cutaneous presentation in an HIV-positive patient

Cited by 6 publications

References 4 publications

Chronic generalized fibrotic skin lesions from disseminated leishmaniasis caused by Leishmania martiniquensis in two patients from northern Thailand infected with HIV

Chronic generalized fibrotic skin lesions from disseminated leishmaniasis caused by Leishmania martiniquensis in two patients from northern Thailand infected with HIV

Diffuse cutaneous leishmaniasis in an immunocompromised patient resembling histoid Hansen's disease

Unusual presentation of mucocutaneous leishmaniasis in HIV-infected patient

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