Diffuse Hepatic Hemangiomatosis in the Adult without Extra-hepatic Involvement: An Extremely Rare Occurrence

Batista, Alexandre; Matos, António P.; Neta, Jorge; Ramalho, Miguel

doi:10.4103/2156-7514.139733

Cited by 9 publications

(5 citation statements)

References 11 publications

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“…Our patients have done very well and have remained asymptomatic since the diagnoses, 9 years prior to this publication. Other reports described similarly favorable outcomes, although most patients were followed for less than 5 years [13] , [14] , [16] , [22] , [23] , [25] , [26] . Nonetheless, not all reported cases had the same uneventful course.…”

Section: Discussionmentioning

confidence: 73%

Isolated hepatic hemangiomatosis in 2 septuagenarians

Liu

Little

2018

Radiology Case Reports

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We report 2 cases of isolated hepatic hemangiomatosis: a 76-year-old woman who is, to our knowledge, the oldest person with this diagnosis, and a 74-year-old woman. Magnetic resonance imaging of the abdomen showed T2 hyper intense lesions throughout the liver, peripheral nodular arterial enhancement, and filling of contrast on the portal venous and delayed phases. Computed tomography showed liver lesions with peripheral nodular enhancement in the early phase and a centripetal pattern or “filling in” during the late phase; the lesions opacified after a delay of 3 or more minutes and remained isodense or hyperdense on delayed scans. Both images were consistent with hepatic hemangiomatosis. These cases help increase awareness about benign and unusual liver lesions with radiologic characteristics similar to those of malignant liver tumors. The authors also present a review of 15 other cases of isolated hepatic hemangiomatosis reported in English literature from 1970 to present.

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Section: Discussionmentioning

confidence: 73%

Isolated hepatic hemangiomatosis in 2 septuagenarians

Liu

Little

2018

Radiology Case Reports

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“…Hepatic hemangiomas are among the most prevalent primary liver tumors classified as non-epithelial lesions [11]. Diffuse hepatic hemangiomatosis (DHH) is a rare, most frequently benign condition in which there is widespread substitution of liver tissue by hemangiomatous tumors and usually occurs in newborns [12].…”

Section: Rare Liver Transplants Indications 21 Hepatic Hemangiomatosismentioning

confidence: 99%

Exceptional Liver Transplant Indications: Unveiling the Uncommon Landscape

Cabel,

Pascu,

Ghenea

et al. 2024

Diagnostics

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Liver transplantation represents the definitive intervention for various etiologies of liver failure and encompasses a spectrum of rare indications crucial to understanding the diverse landscape of end-stage liver disease, with significantly improved survival rates over the past three decades. Apart from commonly encountered liver transplant indications such as decompensated cirrhosis and liver cancer, several rare diseases can lead to transplantation. Recognition of these rare indications is essential, providing a lifeline to individuals facing complex liver disorders where conventional treatments fail. Collaborative efforts among healthcare experts lead not only to timely interventions but also to the continuous refinement of transplant protocols. This continued evolution in transplant medicine promises hope for those facing diverse and rare liver diseases, marking a paradigm shift in the landscape of liver disease management.

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“…In B-mode ultrasound the lesions appear frequently hyperechoic or hypoechoic and the boundary of the lesions is usually ill-defined as compared to multiple HH where the lesions are well delineated. DHH is more frequently seen in newborns where the entire liver is usually involved but uncommon cases of isolated DHH without extrahepatic involvement may be seen in the adult population (about 17 cases in the literature)[ 14 , 50 ].…”

Section: Hh Variantsmentioning

confidence: 99%

One stop shop approach for the diagnosis of liver hemangioma

Săndulescu¹,

Urhut²,

Sandulescu³

et al. 2021

WJH

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Hepatic hemangioma is usually detected on a routine ultrasound examination because of silent clinical behaviour. The typical ultrasound appearance of hemangioma is easily recognizable and quickly guides the diagnosis without the need for further investigation. But there is also an entire spectrum of atypical and uncommon ultrasound features and our review comes to detail these particular aspects. An atypical aspect in standard ultrasound leads to the continuation of explorations with an imaging investigation with contrast substance [ultrasound/ computed tomography/or magnetic resonance imaging (MRI)]. For a clinician who practices ultrasound and has an ultrasound system in the room, the easiest, fastest, non-invasive and cost-effective method is contrast enhanced ultrasound (CEUS). Approximately 85% of patients are correctly diagnosed with this method and the patient has the correct diagnosis in about 30 min without fear of malignancy and without waiting for a computer tomography (CT)/MRI appointment. In less than 15% of patients CEUS does not provide a conclusive appearance; thus, CT scan or MRI becomes mandatory and liver biopsy is rarely required. The aim of this updated review is to synthesize the typical and atypical ultrasound aspects of hepatic hemangioma in the adult patient and to propose a fast, non-invasive and cost-effective clinical-ultrasound algorithm for the diagnosis of hepatic hemangioma.

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Diffuse Hepatic Hemangiomatosis in the Adult without Extra-hepatic Involvement: An Extremely Rare Occurrence

Cited by 9 publications

References 11 publications

Isolated hepatic hemangiomatosis in 2 septuagenarians

Isolated hepatic hemangiomatosis in 2 septuagenarians

Exceptional Liver Transplant Indications: Unveiling the Uncommon Landscape

One stop shop approach for the diagnosis of liver hemangioma

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