Diffuse lamellar keratitis after corneal crosslinking in a patient with post-laser in situ keratomileusis corneal ectasia

Abstract

A 27-year-old man presented with corneal ectasia in his left eye 4 years after myopic laser in situ keratomileusis (LASIK) and was treated with riboflavin-ultraviolet-A (crosslinking). During the first post-treatment days, diffuse lamellar keratitis (DLK) (stage III) developed. The microbiology culture was negative. After intensive treatment with topical corticosteroids, the DLK resolved during the following 2 weeks. Crosslinking for post-LASIK corneal ectasia may induce DLK. Early diagnosis and appropriate treatment with intensive topical corticosteroids is essential to successfully manage this post-crosslinking complication.

Corneal collagen crosslinking using riboflavin and ultraviolet-A light for keratoconus

“…31 In addition, surgeons must be aware of potential complications of the procedure. 32,33 Given the mounting clinical evidence, it would be preferable to treat earlier stages of progressive keratoconus in an effort to better preserve visual acuity. Future therapies may be optimized by combining the crosslinking procedure with intracorneal rings 34 and topography-guided photorefractive keratectomy 35 and might even provide the possibility of reversing the ectasia.…”

Herpetic keratitis after corneal collagen cross-linking with riboflavin and ultraviolet-A for progressive keratoconus

“…With more widespread application of the technique, reports of side-effects and complications are increasing [3][4][5][6][7]. In this case report, we present a patient who developed herpetic keratitis in the early postoperative period after CXL.…”

Post Laser-assisted in situ Keratomileusis Ectasia: A Systematic Review

“…49 Though rare, infectious keratitis following CXL is also reported. [50][51][52] Cross-linking for post-LASIK corneal ectasia may induce diffuse lamellar keratitis (DLK) 53 an accumulation of inflammatory infiltrates beneath the corneal flap interface. Early diagnosis and prompt treatment with topical corticosteroids result in favorable resolution.…”