Diffuse large B cell lymphoma of submandibular gland in a seropositive case – a rare presentation

Abstract

Lymphomas account for 2%-5% of salivary gland neoplasms. The parotid gland is the most commonly involved, constituting 70% of the cases, followed by submandibular gland (25%), sublingual and minor salivary glands (<10%). In present study a 56 years old seropositive male presented with a submandibular gland swelling of 2 months duration; along with multiple cervical lymphadenopathy. Grossly a single, well encapsulated, grayish-white tissue measuring 3x2.5x2 cms was received. It was solid, grayish-white on cut section. Histology revealed features of diffuse large B cell lymphoma with myoepithelial sialadenitis. Immunohistochemistry showed positivity for LCA & CD20, thus confirming the histopathological diagnosis. Primary malignant lymphoma of salivary glands is uncommon. Inspite of malignant lymphoma being the second most common AIDS-associated neoplasm, it’s occurrence in submandibular gland is extremely rare.

Follicular Lymphoma Mimicking a Benign Submandibular Gland Tumor

“…The third most common malignancy in the head and neck area after squamous cell carcinoma and adenocarcinoma is lymphoma. Its accounts for 2%-5% of salivary gland neoplasms [1,2,3]. The parotid glands are most frequent involved, accounting for 70% of cases, followed by the submandibular glands (25%), sublingual glands, and minor salivary glands (<10%) [1,2,3,4,5].…”

“…Its accounts for 2%-5% of salivary gland neoplasms [1,2,3]. The parotid glands are most frequent involved, accounting for 70% of cases, followed by the submandibular glands (25%), sublingual glands, and minor salivary glands (<10%) [1,2,3,4,5].…”

“…They are predominantly nodal and primarily found in the nasal cavity, paranasal sinuses, Waldeyer's ring, oral cavity, and salivary glands [7]. A salivary gland NHL is rare, most effective 5-10%, and represents 1.7% -3.1% of all salivary gland malignant tumors [2,3,6,7,9,10,11,12]. Rzepakowska et al reported 73.2% of nodal type lymphomas and 26.8% of extra-nodal type, which covered: submandibular glands, parotid glands, parapharyngeal space, hypopharynx, and larynx [13].…”