Diffuse large B cell lymphoma primarily presenting as acute liver failure in a surviving patient

Shibata, Jumpei; Kurahashi, Shingo; Naito, Tatsuo; Sugiura, Isamu

doi:10.1080/20009666.2019.1583535

Cited by 8 publications

(6 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of note, ALF due to diffuse large B-cell lymphoma is reported to account for only 0.26% (5/1910) [1]; to date, only ten cases of ALF due to diffuse large B-cell lymphoma have been reported (Table 1) [6][7][8][9][10][11][12][13][14][15], with the time to death following admission in six reported cases being 5 days [12,13], 8 days [7,9], 14 days [14], and 19 days [6], in contrast to only 3 days in the present case. It has been reported that the deaths were caused by multi-organ failure involving cardiovascular collapse, acute lung injury, and renal failure, in addition to hepatic failure [5].…”

Section: Discussionmentioning

confidence: 99%

“…While there have been a few case reports showing that long-term survival could be achieved with chemotherapy in patients with ALF [8,11,15] and that the diagnosis of ALF is facilitated by liver biopsy, bone marrow biopsy, and gastric biopsy (Table 1), Rich et al highlighted the importance of early tissue sampling through liver biopsy [1], suggesting that early diagnosis by biopsy and treatment are crucial for survival in patients with ALF. However, liver biopsy should be carefully considered in ALF patients depending on their risk of complications, which may have been increased with coagulopathy and thrombocytopenia.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Acute liver failure associated with diffuse large B-cell lymphoma: an autopsy case report

Kubo

Kimura

Mabe

et al. 2020

Clin J Gastroenterol

View full text Add to dashboard Cite

Acute liver failure (ALF) associated with malignant infiltration of the liver is rare and its pathological and radiologic features remain poorly described. An 87-year-old man was admitted to our hospital for anorexia for several days, high-grade fever from the previous day, and liver dysfunction but suddenly died on day 3 of hospitalization due to ventricular fibrillation. The patient was diagnosed at autopsy with malignant diffuse large B-cell lymphoma. To the best of our knowledge, this report represents a valuable addition to the ALF literature describing a case of ALF associated with diffuse large B-cell lymphoma diagnosed at autopsy.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Acute liver failure associated with diffuse large B-cell lymphoma: an autopsy case report

Kubo

Kimura

Mabe

et al. 2020

Clin J Gastroenterol

View full text Add to dashboard Cite

show abstract

“…However, hematologic malignancies cannot be ignored, especially lymphoma. Hepatic infiltration of tumor cells can be observed in 15%-22% of hematological malignancies[ 15 ], rarely leading to significant liver dysfunction[ 16 - 20 ], which usually occurs in the terminal stage of the disease[ 16 , 17 , 21 , 22 ] and is closely related to high mortality (67%-100%)[ 16 ]. Although rare, some case reports have described this course of disease.…”

Section: Discussionmentioning

confidence: 99%

Early postsurgical lethal outcome due to splenic littoral cell angioma: A case report

Fan¹,

Lin²,

Li³

et al. 2023

World J Clin Cases

View full text Add to dashboard Cite

BACKGROUND Littoral cell angioma (LCA) is a rare benign vascular tumor of the spleen. Given its rarity, standard diagnostic and therapeutic recommendations have yet to be developed for reported cases. Splenectomy is the only method of obtaining a pathological diagnosis and providing treatment to obtain a favorable prognosis. CASE SUMMARY A 33-year-old female presented with abdominal pain for one month. Computed tomography and ultrasound revealed splenomegaly with multiple lesions and two accessory spleens. The patient underwent laparoscopic total splenectomy and accessory splenectomy, and splenic LCA was confirmed by pathology. Four months after surgery, the patient presented with acute liver failure, was readmitted, rapidly progressed to multiple organ dysfunction syndrome and died. CONCLUSION Preoperative diagnosis of LCA is challenging. We systematically reviewed online databases to identify the relevant literature and found a close relationship between malignancy and immunodysregulation. When a patient suffers from both splenic tumors and malignancy or immune-related disease, LCA is possible. Due to potential malignancy, total splenectomy (including accessory spleen) and regular follow-up after surgery are recommended. If LCA is diagnosed after surgery, a comprehensive postoperative examination is needed.

show abstract

“…Thus, earlier diagnosis and treatment should be the primary goal. A search of the literature found five cases of survival in patients with ALF associated with extranodal DLBCL [16][17][18][19][20]. All five of these patients received a variation of standard therapy based off the R-CHOP regimen, but specific treatment differed significantly from one patient to the next.…”

Section: Discussionmentioning

confidence: 99%

Acute Liver Failure With Severe Lactic Acidosis Secondary to Infiltrative Diffuse Large B-Cell Lymphoma: An Imaging-Negative Presentation

Hafner

Eaton²

2020

Cureus

View full text Add to dashboard Cite

Liver involvement by non-Hodgkin's lymphoma is common in late stage disease but rarely results in severe hepatic dysfunction. Here, we discuss a case of acute liver failure (ALF) with severe lactic acidosis in a 75-year-old female with diffuse large B-cell lymphoma (DLBCL). The patient was admitted with nausea, fevers, and mild acidosis. Although radiographic imaging did not demonstrate any liver abnormality, the patient soon developed signs of ALF along with severe lactic acidosis. Despite initiation of chemotherapy, the patient deteriorated quickly and was ultimately put on comfort measures. This case highlights an uncommon manifestation of DLBCL and suggests that an accelerated timeline for beginning chemotherapy may be warranted in patients with high clinical suspicion of secondary hepatic lymphoma.

show abstract

Diffuse large B cell lymphoma primarily presenting as acute liver failure in a surviving patient

Cited by 8 publications

References 13 publications

Acute liver failure associated with diffuse large B-cell lymphoma: an autopsy case report

Acute liver failure associated with diffuse large B-cell lymphoma: an autopsy case report

Early postsurgical lethal outcome due to splenic littoral cell angioma: A case report

Acute Liver Failure With Severe Lactic Acidosis Secondary to Infiltrative Diffuse Large B-Cell Lymphoma: An Imaging-Negative Presentation

Contact Info

Product

Resources

About