Diffuse Large B-Cell Lymphoma in the Era of Precision Oncology: How Imaging Is Helpful

Shah, Hina; Keraliya, Abhishek; Jagannathan, Jyothi P.; Tirumani, Sree Harsha; Lele, Vikram; DiPiro, Pamela J.

doi:10.3348/kjr.2017.18.1.54

Cited by 24 publications

(21 citation statements)

References 88 publications

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“…Massive painless bilateral cervical lymph-node enlargement can help in considering RDD, whereas lymphoma may feature enlargement and fusion of lymph nodes. In addition, the splenomegaly and diffused hypermetabolism in bone marrow seen on FDG-PET images may be an indication for lymphoma [ 14 , 15 ] because RDD can seldom cause a whole-body reactive response. Although the uptake of FDG in RDD is not specific, [ 16 ] some research highlights that whole-body PET/CT imaging can show the extent of the disease, help with complete staging, provide functional information about disease activity to guide biopsy, and even be used to monitor the follow-up therapeutic response.…”

Section: Discussionmentioning

confidence: 99%

Multimodality imaging-based evaluation of Rosai–Dorfman disease in the head and neck

Liu

2017

Medicine

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Rosai–Dorfman disease (RDD) is an uncommon benign entity characterized histologically by lymphatic sinus dilatation due to histiocyte proliferation. This study was performed to delineate its imaging features, reviewed retrospectively in 12 patients (8 women and 4 men, mean age 58.2 years [range 27–84]) with pathologically confirmed RDD in the head and neck. The location, involvement, and imaging characteristics (CT, magnetic resonance imaging (MRI), and PET/CT) of all lesions were evaluated. Signal intensity on MRI images was compared to gray matter (orbital RDD) and adjacent muscle (sinonasal and cervical RDD). RDD in the head and neck involved multiple sites, primarily the sinonasal cavity (n = 7), neck (n = 3), and orbit (n = 1), with one case of simultaneous involvement of the sinonasal cavity, orbit, and neck. With sinonasal involvement, MRI signal intensity of the involved areas was isointense or slightly hyperintense relative to adjacent muscle on T1WI images and heterogeneous on T2WI images; with lacrimal involvement, it was isointense relative to gray matter on T1- and T2-weighted images; and with neck involvement, it was isointense relative to muscle on T1WI images and relatively hyperintense on T2WI images, with homogenous postcontrast enhancement in all sites of involvement. The lesions on CT were observed as enhancing masses with or without bony destruction. PET/CT showed hypermetabolism in one lesion in the neck. RDD is a rare disorder with multiple sites of involvement in the head and neck. Concomitant cervical lymphadenopathy with extranodal masses assisted by multimodal imaging may be useful in the diagnosis of RDD.

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Section: Discussionmentioning

confidence: 99%

Multimodality imaging-based evaluation of Rosai–Dorfman disease in the head and neck

Liu

2017

Medicine

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“…Diffuse large B‐cell lymphoma (DLBCL), mantle cell lymphoma (MCL), Burkitt lymphoma, and peripheral T‐cell lymphomas represent the main aggressive subtypes. DLBCL is the most common accounting for approximately 30% of all NHLs . DLBCL, like most aggressive lymphomas, displays high FDG uptake .…”

Section: Aggressive Lymphomasmentioning

confidence: 99%

Whole‐body magnetic resonance imaging (WB‐MRI) in lymphoma: State of the art

Albano

Bruno

Patti

et al. 2019

Hematological Oncology

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The improvements in magnetic resonance imaging (MRI) technology and the concern related to the increased cancer risk in patients with lymphoma, also due to radiation exposure associated with imaging examinations, have led to the introduction of whole‐body MRI (WB‐MRI) as a radiation‐free alternative to standard imaging procedures. WB‐MRI seems a less histology‐dependent functional imaging test than 18F‐fluorodeoxyglucose‐positron emission tomography/CT (18F‐FDG‐PET/CT). In patients with FDG‐avid lymphomas, such as diffuse large B‐cell lymphoma (DLBCL) and Hodgkin lymphoma (HL), 18F‐FDG‐PET/CT remains the imaging reference standard for staging, with WB‐MRI potentially being a complementary modality that could replace CT, especially in young patients. On the other hand, WB‐MRI is a valuable imaging procedure for lymphoma surveillance and in lymphomas with variable/low FDG avidity and nonfollicular indolent lymphomas. The aim of this paper is to discuss the current state of the art of WB‐MRI in lymphoma by evaluating its diagnostic performance in different lymphoma subtypes: Hodgkin, aggressive, and indolent lymphomas.

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“…Imaging plays an important role in the detection and evaluation of AR-NHL lesions (8,10,12). CT of the head and neck, chest, abdomen, and pelvis is a critical staging modality recommended by the National Comprehensive Cancer Network guidelines (18).…”

Section: Discussionmentioning

confidence: 99%

“…With the advancement of imaging technology such as CT, MR and PET/CT, radiologic techniques play an increasingly essential role in detecting lesion and evaluating disease (8)(9)(10). CT can nd the enlargement of lymph nodes and in ltration of extranodal organs, guide biopsy and observe early relapse through follow-up (11,12). MR has similar e cacy of detecting the space occupying effect with CT.…”

Section: Introductionmentioning

confidence: 99%

CT Imaging Characteristics Correlated with Overall Survival Time in Patients with AIDS-Related non-Hodgkin’s Lymphoma

Pan

Zheng

et al. 2020

Preprint

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Background CT can provide useful information for treatment regimens and prognosis prediction of patients with AIDS-related non-Hodgkin’s lymphoma (AR-NHL). It is necessary to investigate the prediction of CT imaging and clinical characteristics for overall survival (OS) in patients with AR-NHL.Methods Data of 121 AR-NHL patients [median age: 41 (range 22-78), 112 male] between July 2012 and November 2019 were retrospectively reviewed. Patients were divided into two groups by median OS time and data were compared between two groups. K-M survival analysis and Cox proportional hazards regression analysis were used to determine the prognostic risk factors for OS.Results The median OS time was 17 months. In the K-M survival analysis, presence of extracapsular infiltration (p=0.032), necrosis (p=0.005), CD4 ≤ 100 cells/μL (p=0.020), period from finding mass to admission﹥1 month (p=0.013), without chemotherapy (p﹤0.001), liver involved (p﹤0.001), gastrointestinal tract involved (p=0.015) and mediastinal or hilar lymph nodes involved (p=0.022) were associated with shorter OS. In the multivariate Cox regression analysis, liver involved (HR=2.48, 95%CI 1.45–4.25, P=0.001), mediastinal or hilar lymph nodes involved (HR=1.70, 95%CI 1.02–2.83, P=0.042), necrosis in lesion (HR=2.02, 95%CI 1.21–3.36, P=0.007) and CD4 ≤ 100 cells/μL (HR=2.66, 95%CI 1.42–4.98, P=0.002) were independently risk factors for shorter OS. Chemotherapy (HR=0.48, 95%CI 0.26–0.89, P=0.020) was independently protective factor for shorter OS. The predictive models based on Cox regression has good discrimination (Harrell’s C-index=0.716) and good calibration (Hosmer-Lemeshow test, p=0.620). Conclusion When the tumor had necrosis and extracapsular infiltration, involvement of mediastinal or hilar lymph nodes, liver, gastrointestinal tract in CT images, the overall prognosis was poor. And intensive chemotherapy regimens and more frequent follow-up should be considered.

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Diffuse Large B-Cell Lymphoma in the Era of Precision Oncology: How Imaging Is Helpful

Cited by 24 publications

References 88 publications

Multimodality imaging-based evaluation of Rosai–Dorfman disease in the head and neck

Multimodality imaging-based evaluation of Rosai–Dorfman disease in the head and neck

Whole‐body magnetic resonance imaging (WB‐MRI) in lymphoma: State of the art

CT Imaging Characteristics Correlated with Overall Survival Time in Patients with AIDS-Related non-Hodgkin’s Lymphoma

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