2014
DOI: 10.1136/bcr-2014-205272
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Diffuse large B-cell lymphoma in the sphenoid sinus mimicking fibrous dysplasia in CT and MRI

Abstract: SUMMARYWe present a 70-year-old man with lymphoma who presented with a right eye movement disorder. CT examinations showed 'ground-glass' appearance extending around the right sphenoid sinus which suggested fibrous dysplasia. However, biopsy from the mass histologically proved it to be diffusing large B-cell lymphoma and positron emission tomography examinations revealed increased fluorodeoxyglucose (FDG) uptake around the right sphenoid bone and multiple spinal bones. After chemotherapy for lymphoma, abnormal… Show more

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Cited by 6 publications
(7 citation statements)
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“…As far as we have reviewed, 15 cases of sphenoid lymphoma including this case have been reported with detailed clinical history [ Table 1 ]. [ 1 , 2 , 4 - 8 , 10 - 14 ] Nasal obstruction or discharge appeared only in 5 patients (33.3%), unlike its high occurrence in other paranasal sinus tumors. Eleven patients (73.3%) initially presented with ptosis or diplopia caused by cranial nerve II, III, IV, and VI palsy.…”
Section: Discussionmentioning
confidence: 96%
“…As far as we have reviewed, 15 cases of sphenoid lymphoma including this case have been reported with detailed clinical history [ Table 1 ]. [ 1 , 2 , 4 - 8 , 10 - 14 ] Nasal obstruction or discharge appeared only in 5 patients (33.3%), unlike its high occurrence in other paranasal sinus tumors. Eleven patients (73.3%) initially presented with ptosis or diplopia caused by cranial nerve II, III, IV, and VI palsy.…”
Section: Discussionmentioning
confidence: 96%
“…Primary B-cell lymphoma of the sphenoid sinus is very rare, having an incidence of 0.03 per 100,000 persons between 2000-2012 [1,2,5,6]. B-cell lymphomas remain the most common non-epithelial tumors of the paranasal sinuses [2,7].…”
Section: Discussionmentioning
confidence: 99%
“…Surgery may be possible in select cases [1,4]. Prophylactic intrathecal chemotherapy may be utilized as there is a potential for recurrence in the CNS [6]. Biopsy of sphenoid sinus opacification must be considered in chronic sinusitis or when other previously mentioned signs/symptoms occur [5,10,12,13].…”
Section: Discussionmentioning
confidence: 99%
“…The majority of cases are not as responsive to surgery; however, when compared to a combination of chemotherapy and radiation 2 . Prophylactic intrathecal chemotherapy may be utilized as there is a potential for recurrence in the CNS 6 . Biopsy of sphenoid sinus opacification must be considered in chronic sinusitis or when other previously mentioned signs/symptoms occur 5,14,19,20 .…”
Section: Discussionmentioning
confidence: 99%