Diffuse large B-cell lymphoma of the mandible with periosteal reaction: a case report

Okahata, Ryoko; Shiba, Hiroaki; Marutani, Keisuke; Tomita, Shuichiro; Nakatani, Atsutoshi; Kishino, Mitsunobu; Kakimoto, Naoya; Murakami, Shumei; Furukawa, Souhei

doi:10.1016/j.oooo.2013.12.002

Cited by 11 publications

(17 citation statements)

References 19 publications

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“…The clinical features, such as swelling, pain, paresthesia, tooth mobility, or pathologic fracture, are frequent but non-specific, which may lead to misdiagnosis. In the literature, several reports illustrate the challenging diagnosis of oral lymphoma 6 - 8. Here, we present an uncommon case of primary NHL of the mandible, which was initially misdiagnosed as periodontal disease.…”

Section: Introductionmentioning

confidence: 92%

Primary diffuse large B-cell lymphoma of the mandible

et al. 2019

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Primary intraosseous non-Hodgkin lymphoma in the mandible is uncommon, representing about 0.6% of all extranodal lymphomas. We present the case of a 51-year-old male with a 4-month complaint of mandibular swelling and paresthesia, which had been previously submitted to an unsuccessful periodontal treatment. The intra-oral evaluation showed an extensive swelling with teeth mobility in the right mandible body. The panoramic radiography and computed tomography images showed an extensive osteolytic lesion. An incisional biopsy was performed and the histopathological and immunohistochemical analysis established the diagnosis of diffuse large B-cell lymphoma. The treatment included six cycles of chemotherapy with complete remission. The patient is under the seventh month of follow-up with no evidence of relapse. Although uncommon in the oral cavity, lymphoma should be considered in the differential diagnosis.

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Section: Introductionmentioning

confidence: 92%

Primary diffuse large B-cell lymphoma of the mandible

et al. 2019

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“…The maxilla is more frequently affected and mandibular lesions account for only 0.6% out of all NHLs. 3,9 Lymphoma of the mandible is very easily misdiagnosed with consequent therapeutic delay due to its rarity and absence of specific signs and symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…11 In elderly, infectious etiologies (e.g., abscess or osteomyelitis) and primary nonodontogenic lesions (e.g., sarcomas, lymphoma, and metastasis) should be considered. 11 Radiographic findings on OPG images may be absent in up to 20% of lymphomas, 3,12 and usually they are unspecific. The most common appearance of primary bone lymphomas is a permeative pattern, characterized by spread of tumor cells from the bone marrow through small vascular channels that go through the cortex into the surrounding soft tissue.…”

Section: Discussionmentioning

confidence: 99%

“…However, primary NHL rarely occurs in maxilla or mandible accounting only for 0.6% out of all NHLs. 3 These percentages reflect the general low incidence of primary bone lymphomas (5% out of all extranodal NHL and 2% out of all lymphomas). 5,6 Lymphoma of the jaw does not have any specific clinical and radiological features; it often appears as an odontogenic process, thus delaying the diagnosis.…”

Section: Introductionmentioning

confidence: 87%

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Odontogenic-Like Pain in Partial Edentulism: An Unusual Presentation of Diffuse Large B-Cell Lymphoma of the Mandible

Catania

Belloni²,

Preda

et al. 2021

Indian J Radiol Imaging

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Primary bone lymphoma is a rare entity and it usually occurs in long bones. Primary mandibular involvement is very rare, and it usually shows unspecific features, mimicking odontogenic inflammatory lesions. We present the unusual case of a diffuse large B-cell lymphoma (DLBCL) of the right mandibular body in a 91-year-old woman, who presented with acute pain in the mandibular region initially suspicious for odontogenic abscess. No significant findings were seen on orthopantomography (OPG) and her almost complete edentulism made the diagnosis of abscess unlikely. Computed tomography and magnetic resonance images showed an expansive mass around the right mandibular body with erosion of cortical bone and involving the right mandibular canal and nerve. Final diagnosis of DLBCL was pathologically proven. The presence of odontogenic-like pain in nearly complete edentulism should be suspicious for malignancy, and it needs further diagnostic workup despite the absence of signs on OPG.

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“…They arise from the medullary cavity and manifest as a localized, solitary lesion. 17 Non-Hodgkin's lymphoma usually expresses pan B-cell markers, such as CD19, CD20, CD75, CD79a, and CD22; but may lack one or more of these. Surface and or cytoplasmic immunoglobulins (IgM > IgG > IgA) can be demonstrated in 50 to 75% of cases.…”

Section: Discussionmentioning

confidence: 99%

Primary Diffuse Large B-cell Lymphoma involving the Mandible

Alshahrani¹,

Aljabab²,

Motabi³

et al. 2015

The Journal of Contemporary Dental Practice

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Lymphomas of the oral cavity are rare and typically present as intraosseous lesions that are most commonly diffuse large B-cell type. Diffuse large B-cell lymphoma (DLBCL) is an aggressive B-cell lymphoma histologically characterized by diffuse proliferation of large neoplastic B-lymphoid cells with a nuclear size equal to or exceeding normal histiocytic nuclei. A case of DLBCL of the mandible in an 18 years old male patient is presented. This report discusses this rare malignancy, including clinical presentation, histopathologic features, immunologic profile, treatment and prognosis. Though lymphoma of mandible is rare, it must be considered in differential diagnosis of swellings arising in the region.

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Diffuse large B-cell lymphoma of the mandible with periosteal reaction: a case report

Cited by 11 publications

References 19 publications

Primary diffuse large B-cell lymphoma of the mandible

Primary diffuse large B-cell lymphoma of the mandible

Odontogenic-Like Pain in Partial Edentulism: An Unusual Presentation of Diffuse Large B-Cell Lymphoma of the Mandible

Primary Diffuse Large B-cell Lymphoma involving the Mandible

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