Diffuse Large B-Cell Lymphoma

Chan, Alexander; Chan, John K. C.

doi:10.1016/b978-0-7216-0040-6.00022-8

Cited by 22 publications

(34 citation statements)

References 383 publications

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“…23 The median age is 64 years, but patients of any age can be affected. 24 Patients typically present with rapidly enlarging lymph nodes or tumor masses in extranodal sites. 24 Waldeyer's ring is a common extranodal site.…”

Section: A Louissaint Jr Et Almentioning

confidence: 99%

“…24 Patients typically present with rapidly enlarging lymph nodes or tumor masses in extranodal sites. 24 Waldeyer's ring is a common extranodal site. 24 Diffuse large B-cell lymphoma characteristically shows a diffuse pattern of infiltration, commonly resulting in total architectural effacement of lymph or tonsillar architecture.…”

Section: A Louissaint Jr Et Almentioning

confidence: 99%

“…24 Waldeyer's ring is a common extranodal site. 24 Diffuse large B-cell lymphoma characteristically shows a diffuse pattern of infiltration, commonly resulting in total architectural effacement of lymph or tonsillar architecture. However, in some cases, involvement by diffuse large B-cell lymphoma may show partial architectural effacement, and partial nodal involvement may occasionally be interfollicular, sometimes making distinction from infectious mononucleosis particularly difficult.…”

Section: A Louissaint Jr Et Almentioning

confidence: 99%

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Infectious mononucleosis mimicking lymphoma: distinguishing morphological and immunophenotypic features

et al. 2012

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The diagnosis of infectious mononucleosis (acute Epstein-Barr virus (EBV) infection) is usually made on the basis of clinical and laboratory findings. However, an atypical clinical presentation occasionally results in a lymph node or tonsillar biopsy. The morphological features of EBV-infected lymphoid tissue can easily mimic lymphoma. Furthermore, the immunophenotype of the immunoblasts has not been well characterized. To assess the morphological spectrum of acute EBV infection and the utility of immunohistochemistry in diagnosing difficult cases that resemble lymphoma, we reviewed 18 cases of acute EBV infection submitted in consultation to our institution with an initial diagnosis of/or suspicion for lymphoma. Patients included nine male and nine female individuals with a median age of 18 years (range 9-69). Biopsies were obtained from lymph nodes (3/18) or Waldeyer's ring (15/18). Infectious mononucleosis was confirmed by monospot or serological assays in 72% of cases (13/18). All cases featured architectural distortion by a polymorphous infiltrate with an immunoblastic proliferation, sometimes forming sheets. Reed-Sternberg-like cells were present in 8/18 (44%) of the cases. Infiltrates were often accompanied by necrosis (10/18) and mucosal ulceration (6/15). The majority of immunoblasts in all cases were CD20 þ B cells with a post-germinal center immunophenotype (strongly positive for MUM1/IRF4 (18/18), CD10À (18/18 negative) and BCL-6À (16/18 negative; 2/18 faint BCL-6 expression in o10% of immunoblasts)). Immunoblasts showed variable weak expression of BCL-2 and polyclonal expression of j and k immunoglobulin light chains in 81% cases. ReedSternberg-like cells in 8/8 cases were CD30 þ , CD15À, BOB.1 þ and OCT-2 þ . In conclusion, an atypical lymphoid infiltrate with numerous MUM1 þ , CD10À, BCL-6À immunoblasts should raise the suspicion of a reactive process, such as infectious mononucleosis, and warrants additional consideration before a diagnosis of lymphoma is made.

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Section: A Louissaint Jr Et Almentioning

confidence: 99%

Section: A Louissaint Jr Et Almentioning

confidence: 99%

Section: A Louissaint Jr Et Almentioning

confidence: 99%

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Infectious mononucleosis mimicking lymphoma: distinguishing morphological and immunophenotypic features

et al. 2012

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“…By the early years of the new century, our practice in terms of both Non Hodgkin and Hodgkin Lymphomas (HL) was well established. Based on the WHO terminologies, and with newer IHC markers to supplement the morphology, we began to diagnose not just the older entities with greater confidence but started to recognize and report newer entities like Anaplastic Large Cell Lymphoma (ALCL) (Kinney et al, 1991), blastoid variant of Mantle Cell Lymphoma (Zucca et al, 1994), anaplastic and ALK positive variants of Diffuse Large B Cell Lymphoma (DLBCL) (Haralambieva et al, 2000;Delsol et al, 2008;WHO, 2008;Chan and Chan, 2010), Extranodal Natural Killer (NK)/T cell lymphoma (Chan et al, 2008;WHO, 2008) Post-Transplant lymphoproliferative disorder (PTLD) WHO, 2008) etc. We also published a case of Post-transplant peripheral T cell lymphoma (Ahmad et al, 2007).…”

Section: Lymph Node Pathologymentioning

confidence: 99%

How Our Practice of Histopathology, Especially Tumour Pathology has Changed in the Last Two Decades: Reflections from a Major Referral Center in Pakistan

Ahmad

Idrees²,

Fatima³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Continued advances in the field of histo pathology (and cyto pathology) over the past two decades have resulted in dramatic changes in the manner in which these disciplines are now practiced. This is especially true in the setting of a large university hospital where the role of pathologists as clinicians (diagnosticians), undergraduate and postgraduate educators, and researchers has evolved considerably. The world around us has changed significantly during this period bringing about a considerable change in our lifestyles and the way we live. This is the world of the internet and the world-wide web, the world of Google and Wikipedia, of Youtube and Facebook where anyone can obtain any information one desires at the push of a button. The practice of histo (and cyto) pathology has also evolved in line with these changes. For those practicing this discipline in a poor, developing country these changes have been breathtaking. This is an attempt to document these changes as experienced by histo (and cyto) pathologists practicing in the biggest center for Histopathology in Pakistan, a developing country in South Asia with a large (180 million) and ever growing population. The Section of Histopathology, Department of Pathology and Microbiology at the Aga Khan University Hospital (AKUH) in Karachi, Pakistan's largest city has since its inception in the mid-1980s transformed the way histopathology is practiced in Pakistan by incorporating modern methods and rescuing histopathology in Pakistan from the primitive and outdated groove in which it was stuck for decades. It set histopathology in Pakistan firmly on the path of modernity and change which are essential for better patient management and care through accurate and complete diagnosis and more recently prognostic and predictive information as well.

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“…The mean age of patients with CD5-positive DLBCL is 70 years, with a moderate female predominance (1 : 1.2), in contrast to CD5-negative DLBCL, which prevails in males (1.4 : 1). The majority of patients with CD5-positive DLBCL have a high International Prognostic Index (IPI) score [3,4,5].…”

Section: Introductionmentioning

confidence: 99%

A rare CD5-positive subgroup of diffuse large B-cell lymphoma – clinical, morphological and immunophenotypic features in Polish patients

Woźnialis¹,

Gierej²,

Popławska³

et al. 2016

pjp

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The aim of the study was to assess the incidence of CD5-positive diffuse large B-cell lymphoma (DLBCL) in the Polish population and to describe its morphologic and clinical characteristics. The study included 36 patients with CD5-positive DLBCL, diagnosed and treated in the Maria Skłodowska-Curie Institute and Oncology Centre, Warsaw, Poland and the Medical University of Warsaw, Poland in the years 2002-2013. The control group consisted of 28 patients with CD5-negative DLBCL. CD5-positive DLBCL accounted for 6.26% of all DLBCL cases diagnosed in the Maria Skłodowska-Curie Institute and Oncology Centre in the years 2008-2012. The incidence is comparable to other European countries, lower than noted in Japan and higher than in the US. Patients with CD5-positive DLBCL, in comparison to the CD5-negative group, were characterized by: (1) older age (≥ 60 vs. younger) and worse general status (ECOG ≥ 2 vs. < 2), (2) lower frequency of complete remission (CR), (3) higher expression of unfavorable prognostic factors (BCL2, FOXP1, CD44) and MMP-9, and (4) lower expression of CD30, cyclin D1, cyclin D3 and TIMP-2.

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Diffuse Large B-Cell Lymphoma

Cited by 22 publications

References 383 publications

Infectious mononucleosis mimicking lymphoma: distinguishing morphological and immunophenotypic features

Infectious mononucleosis mimicking lymphoma: distinguishing morphological and immunophenotypic features

How Our Practice of Histopathology, Especially Tumour Pathology has Changed in the Last Two Decades: Reflections from a Major Referral Center in Pakistan

A rare CD5-positive subgroup of diffuse large B-cell lymphoma – clinical, morphological and immunophenotypic features in Polish patients

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