Diffuse malignant melanoma of iris with metastases

Brown, David Bingham; Boniuk, Milton; Font, Ramon L.

doi:10.1016/0039-6257(90)90111-8

Cited by 43 publications

(10 citation statements)

References 17 publications

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“…No tumour mass was identified macroscopically in the enucleated specimen and the diagnosis was only established by microscopy. This case has similarities to the diffuse malignant melanomas reported by Brown et al 18 and Spaulding et al 19. Ring tumours with unusual histology, including T cell lymphoma20 and borderline spindle cell naevus,21 have also been described.…”

Section: Discussionsupporting

confidence: 80%

Ring melanoma---a rare cause of refractory glaucoma

Lee

Cree

Hungerford

1999

British Journal of Ophthalmology

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Background-Ring melanoma of the ciliary body and iris is extremely rare and often has adverse histology. This tumour may cause raised intraocular pressure. Methods-A review of four cases of ring melanomas with insidious presentations seen in the ocular oncology service over a 12 month period. Results-All four patients presented with unilateral anterior segment abnormalities and refractory glaucoma. The misdiagnoses of the causes of the glaucoma included angle recession from previous blunt trauma (patient 1); iridocorneal endothelial (ICE) syndrome supported by endothelial specular microscopy (patients 2 and 3); and melanocytoma on ciliary body biopsy (patient 4). Two patients were treated by several cyclodiode ciliary body ablation treatments and the other two underwent trabeculectomies and Molteno tubes. Two of the four patients have since died from their disease. Conclusion-The ophthalmologist should re-evaluate the diagnosis in patients with anterior segment abnormalities and refractory ipsilateral glaucoma. Endothelial specular microscopy and biopsy of the suspicious lesion may give misleading reassurance. The potential presence of an anterior uveal melanoma must always be considered. (Br J Ophthalmol 1999;83:194-198) Ring melanoma of the ciliary body and iris was first described by the Russian ophthalmologist Ewetsky in 1898 1 who called it a ring sarcoma. It is a rare variant of the "diVuse melanoma" which is defined as a primary uveal tumour that involves more than a quarter of the uveal tract.2 In practice, ring melanomas seldom infiltrate the uveal tract as extensively, but the ciliary body is the main site of involvement. 3The ring may arise from coalescence of tumours arising from multiple sites. Materials and methodsWe reviewed four cases of ring melanomas causing unilateral refractory glaucoma which were seen in the ocular oncology clinic over a 12 month period. Results CASE 1A 23 year old white man was admitted via the accident and emergency in department of a district general hospital with a history of vomiting and malaise. A computed tomograph (CT) scan of the abdomen was performed and showed multiple liver lesions which were biopsied, and which showed poorly diVerentiated round cell tumour of uncertain origin.He was commenced on chemotherapy for extraosseus Ewing's sarcoma. At admission the right pupil was noted to be distorted and a pigmented cystic lesion was noted on the conjunctiva of the right eye. An ophthalmological opinion was sought.Further questioning revealed that the patient had sustained blunt trauma to the right eye from a tennis ball at the age of 10, and 2 years before admission had been diagnosed with glaucoma secondary to angle recession at another eye unit. Iris heterochromia had also been noted. The glaucoma was refractory to conservative treatment and he had undergone two episodes of cyclodiode ciliary body ablation 6 months earlier. The vision had deteriorated over the past year and the eye had become painful.On examination visual acuity was no perception of lig...

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Section: Discussionsupporting

confidence: 80%

Ring melanoma---a rare cause of refractory glaucoma

Lee

Cree

Hungerford

1999

British Journal of Ophthalmology

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“…3 Conversely, iris melanomas, although less frequent, have a good prognosis and only rarely metastasise. 4 Uveal melanomas have been well characterised by cytogenetic studies, owing largely to their relatively simple karyotypes and ease of culture. Cytogenetic studies on posterior uveal melanoma have revealed the presence of recurrent primary aberrations, including loss of chromosome 3 and gain of chromosome 8q.…”

Section: Introductionmentioning

confidence: 99%

Multiple locations on chromosome 3 are the targets of specific deletions in uveal melanoma

Cross

Ganesh

Parpia

et al. 2005

Eye

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“…7 There are a number of reports of malignant melanoma showing infiltration of marrow. [7][8][9][22][23][24] Bone marrow involvement is not common in malignant melanoma cases. Although cases of nondermal malignant melanoma associated with bone marrow infiltration have been described in the literature, [10][11][12][13][14] there were no reports of primary ovarian malignant melanoma cases in whom bone marrow involvement was identified.…”

Section: Discussionmentioning

confidence: 99%

Ovarian malignant melanoma presenting with hypercalcemia and bone marrow infiltration: a case report and review of the literature

Kaplan

Küçüköner²,

İnal³

et al. 2012

J Clin Exp Invest

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ÖZETOver kaynaklı malign melanom oldukça nadir bir durumdur. Kemik iliği tutulumu olması ve hiperkalsemi varlığı malign melanoma vakalarında çok düşük oranda göz-lenmektedir (sırasıyla, % 5-7 and % 1.1-11.9). Bu yazıda biz de kemik iliği infiltrasyonu gösteren ve hiperkalsemisi bulunan oldukça nadir bir 67 yaşında kadın over kaynaklı malign melanoma vakasını sunduk.Anahtar kelimeler: Overiyan malign melanoma, kemik iliği infiltrasyonu, hiperkalsemi ABSTRACT Malignant melanoma originating from the ovary is a very rare condition. Bone marrow involvement and hypercalcemia is observed at a very low rate in malignant melanoma cases (5-7 and 1.1-11.9%, respectively). In this paper, we present very rare condition as a 67-year-old female patient with malignant melanoma of ovary origin accompanied by bone marrow infiltration and hypercalcemia. J Clin Exp Invest 2012; 3(1): 96-98

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Diffuse malignant melanoma of iris with metastases

Cited by 43 publications

References 17 publications

Ring melanoma---a rare cause of refractory glaucoma

Ring melanoma---a rare cause of refractory glaucoma

Multiple locations on chromosome 3 are the targets of specific deletions in uveal melanoma

Ovarian malignant melanoma presenting with hypercalcemia and bone marrow infiltration: a case report and review of the literature

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