Diffuse melanosis cutis: A systematic review of the literature

Sebaratnam, Deshan F; Venugopal, Supriya S.; Frew, John W.; McMillan, James R.; Finkelstein, Eve; Martin, Linda K.; Murrell, Dédée F.

doi:10.1016/j.jaad.2012.08.018

Cited by 33 publications

(56 citation statements)

References 34 publications

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“…Until 2015, 70 cases of DMC were reported, however, the pathophysiological mechanisms of the condition have not been elucidated. [2] So far, several alternative hypotheses concerning etiopathogenesis of DMC were proposed. Several lines of evidence suggest that the direct cause of the skin darkening is melanin derived from the melanoma micrometastases in the dermis.…”

Section: Discussionmentioning

confidence: 99%

“…In rare cases, tumor progression manifests itself as a generalized discoloration of the skin which turns a blue–gray (diffuse melanosis cutis, DMC). [2,3] The discoloration is usually more intensive on sun-exposed areas, including head and upper torso. [4] Usually, DMC is associated with dark urine.…”

Section: Introductionmentioning

confidence: 99%

“…[3,6] The average time from MM diagnosis to the development of DMC is 1 year, and the survival time from the onset of this symptom is approximately 4–5 months. [2] Herein, we present a case of DMC in the course of MM micrometastases to the skin. Due to MM, the patient underwent surgery twice, 30 years ago and 9 months before discoloration of the skin appeared.…”

Section: Introductionmentioning

confidence: 99%

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Diffuse melanosis cutis related to dermal micrometastases as the first clinical symptom of distant metastatic malignant melanoma

Maj

Jankowska‐Konsur²,

Gruber³

et al. 2017

Medicine

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Rationale:Diffuse melanosis cutis (DMC) is a very rare sign of malignant melanoma progression. The condition usually develops after approximately one year from melanoma diagnosis in a patient with metastatic tumors and after anticancer treatment with cytostatic medications.Patient concerns:A 72-year old Caucasian man was admitted to the Department of Dermatology with DMC for 4 months and the history of two melanomas treated surgically 30 years and 9 months before present hospitalization.Diagnosis:Histological and immunohistochemical examinations of DMC biopsy indicated melanoma metastatic cells as well as free deposits of melanin and melanophage presence in the dermis.Interventions:The patient refused to the treatment.Outcomes:The patient died eight months after DMC appeared.Lessons:DMC is a rare presentation of advanced MM and is a bad prognostic factor. The pathomechanisms of the discoloration of the skin are not fully explained. The role of micrometastases, as well as melanin precursors, released during lysis of MM metastases, and growth factors may play a role in the development of the symptom.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Diffuse melanosis cutis related to dermal micrometastases as the first clinical symptom of distant metastatic malignant melanoma

Maj

Jankowska‐Konsur²,

Gruber³

et al. 2017

Medicine

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“…또한 눈의 망막과 홍채에도 분포하며, 검은색의 피모를 가진 동물의 뇌 연질막이나 구강 점막에서 도 관찰할 수 있다. 멜라닌은 tyrosinase에 의해 진피의 바닥 층에 있는 멜라닌세포 세포질의 멜라노솜에서 생산되고, 가 지돌기(dendritic process)를 통해 인접한 각질세포로 운반된 다 [10,11]. 상피의 바닥층에서 염증반응이 일어날 경우, 정 상적인 멜라노솜 운반에 문제가 생겨서 색소가 세포 밖으로 나온다(pigmentary incontinence) [11].…”

Section: 멜라닌(Melanin)은 상피조직에 정상적으로 존재하는 내인 성 색소로써 멜라닌세포 내의 골지체 유래 기관unclassified

“…멜라닌은 tyrosinase에 의해 진피의 바닥 층에 있는 멜라닌세포 세포질의 멜라노솜에서 생산되고, 가 지돌기(dendritic process)를 통해 인접한 각질세포로 운반된 다 [10,11]. 상피의 바닥층에서 염증반응이 일어날 경우, 정 상적인 멜라노솜 운반에 문제가 생겨서 색소가 세포 밖으로 나온다(pigmentary incontinence) [11]. 정상적으로는 멜라닌 색소가 없는 조직에 멜라닌 색소가 존재하는 경우를 멜라닌증(melanosis)이라고 한다 [9].…”

Section: 멜라닌(Melanin)은 상피조직에 정상적으로 존재하는 내인 성 색소로써 멜라닌세포 내의 골지체 유래 기관unclassified

Congenital systemic melanosis in a black mongrel pig

Jeong¹,

Jung²,

Her³

et al. 2015

Korean Journal of Veterinary Research

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: Four 3-day-old piglets with retarded growth were submitted to the Animal and Plant Quarantine Agency for diagnosis. Necropsy showed that one piglet had black spots ranging from 2 mm to 1 cm in diameter in the cerebellum, lungs, regional lymph nodes, and cecum. Histological findings were consistent with the gross appearance in which melanin pigmentation was observed in the organs mentioned above. Based on Fontana-Masson staining, we diagnosed this animal with systemic melanosis. To the best of our knowledge, this is the first case of systemic melanosis in black breeds of swine in Korea.

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A Novel Chromosomal Translocation Associated WithCOL1A2-PDGFBGene Fusion in Dermatofibrosarcoma Protuberans

et al. 2015

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IMPORTANCE Dermatofibrosarcoma protuberans (DFSP) is a rare skin cancer that develops in the deep dermis to subcutaneous adipose tissues. A COL1A1-PDGFB gene fusion, leading to the constitutive expression of PDGFB, is the tumorigenic mechanism in most DFSP cases. OBJECTIVES To evaluate the specificity of PDGFB expression as a diagnostic marker of DFSP and to determine whether other pathomechanisms (ie, gene fusions) exist in patients with DFSP without the COL1A1-PDGFB fusion gene.

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Diffuse melanosis cutis: A systematic review of the literature

Cited by 33 publications

References 34 publications

Diffuse melanosis cutis related to dermal micrometastases as the first clinical symptom of distant metastatic malignant melanoma

Diffuse melanosis cutis related to dermal micrometastases as the first clinical symptom of distant metastatic malignant melanoma

Congenital systemic melanosis in a black mongrel pig

A Novel Chromosomal Translocation Associated WithCOL1A2-PDGFBGene Fusion in Dermatofibrosarcoma Protuberans

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