Diffuse meningeal rhabdomyosarcoma

Smith, Michael T.; Armbrustmacher, Vernon W.; Violett, T. W.

doi:10.1002/1097-0142(19810415)47:8<2081::aid-cncr2820470829>3.0.co;2-1

Cited by 34 publications

(3 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Not all leptomeningeal tumors arise as a result of metastatic disease at other sites. Primary leptomeningeal lymphomas, melanomas, and rhabdosarcomas have been reported previously [13,20–22]. To our knowledge, this is the first ever report of leptomeningeal carcinomatosis in a patient with primary uveal melanoma.…”

Section: Introductionmentioning

confidence: 60%

A rare case of leptomeningeal carcinomatosis in a patient with uveal melanoma: case report and review of literature

et al. 2016

View full text Add to dashboard Cite

Uveal melanoma is a rare subtype of melanoma, accounting for only 3–5% of all melanoma cases in the USA. Although fewer than 4% of uveal melanoma patients present with metastasis at diagnosis, approximately half will develop metastasis, more than 90% of which disseminate to the liver. Infrequently, a number of malignancies can lead to leptomeningeal metastases, a devastating and terminal complication. In this case report, we present an exceedingly rare case of a patient with uveal melanoma who developed leptomeningeal carcinomatosis as the sole site of metastasis. After conventional methods to diagnose leptomeningeal carcinomatosis fell short, a diagnosis was confirmed on the basis of identification and genomic analysis of melanoma circulating tumor cells in the cerebrospinal fluid.

show abstract

Section: Introductionmentioning

confidence: 60%

A rare case of leptomeningeal carcinomatosis in a patient with uveal melanoma: case report and review of literature

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Lumbar puncture or imaging of the craniospinal axis can identify leptomeningeal or multifocal disease which can have implications on radiotherapy fields and total dose. Few cases have reported diffuse meningeal involvement, but it is associated with a poorer prognosis [7, 8]. In addition, an extracranial primary site should be excluded with CT or PET imaging.…”

Section: Literature Reviewmentioning

confidence: 99%

Primary Meningeal Rhabdomyosarcoma

Palta

Riedel

Vredenburgh

et al. 2011

Sarcoma

View full text Add to dashboard Cite

Primary meningeal rhabdomyosarcoma is a rare primary brain malignancy, with scant case reports. While most reports of primary intracranial rhabdomyosarcoma occur in pediatric patients, a handful of cases in adult patients have been reported in the medical literature. We report the case of a 44-year-old male who developed primary meningeal rhabdomyosarcoma. After developing episodes of right lower extremity weakness, word finding difficulty, and headaches, a brain magnetic resonance imaging (MRI) demonstrated a vertex lesion with radiographic appearance of a meningeal-derived tumor. Subtotal surgical resection was performed due to sagittal sinus invasion and initial pathology was interpreted as an anaplastic meningioma. Re-review of pathology demonstrated rhabdomyosarcoma negative for alveolar translocation t(2;13). Staging studies revealed no evidence of disseminated disease. He was treated with stereotactic radiotherapy with concurrent temozolamide to be followed by vincristine, actinomycin-D, and cyclophosphamide (VAC) systemic therapy.

show abstract

“…In leptomeningeal primary malignant neoplasias, rhabdomyoblastic differentiation is even rarer, and Ferracini et al [2] added one more case to the three previously reported in the literature [5][6][7].…”

Section: Introductionmentioning

confidence: 99%