Diffuse mesotheliomas.With comment on their relation to localized fibrous mesotheliomas

Godwin, Melvin Crawford

doi:10.1002/1097-0142(195703/04)10:2<298::aid-cncr2820100211>3.0.co;2-o

Cited by 95 publications

(9 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The wide range of microscopical features reported by many writers and well described and illustrated by Godwin (1957), McCaughey (1958, and Hourihane (1964) were present in this series. Though some admixture of types was found in most cases, the tumours were predominantly of one form in over half the cases.…”

Section: Histological Featuressupporting

confidence: 65%

“…Although Godwin (1957) accepted extensive metastases in several of his cases without comment, later writers have been less willing to accept metastasizing tumours as mesotheliomas. McCaughey (1958) was rather guarded on the subject mentioning metastases to lung and liver but regarding more distant spread as unusual, though not in itself a reason for changing the diagnosis.…”

Section: Chest Wall Operation Site and Diaphragmmentioning

confidence: 99%

“…The recent reinstatement of diffuse malignant pleural mesothelioma as a legitimate neoplasm dates mainly from the papers of Godwin in 1957 andMcCaughey in 1958. However, the controversy as to whether these pleural tumours are primary or almost always secondary might have remained a nice academic exercise but for the work of Wagner, Sleggs, and Marchand who in 1960 reported an association of pleural mesothelioma with asbestos exposure.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Diffuse malignant pleural mesothelioma and asbestos exposure

Whitwell¹,

Rawcliffe²

1971

Thorax

157

View full text Add to dashboard Cite

Pleural mesothelioma has been diagnosed in 52 patients in three hospitals on Merseyside between 1955 and 1970, 60% being diagnosed from operation specimens and the rest from postmortem tissues. Necropsies eventually held on nearly half the operation cases confirmed the diagnosis, giving a necropsy rate of 70% for the series. The morbid anatomy conformed to earlier descriptions except that widespread metastases were much commoner than has usually been described. Histological findings agreed with previous accounts of the tumour, except that, in our hands, special acid mucopolysaccharide staining was less reliable than Southgate's mucicarmine, which was of value in differential diagnosis. Association with asbestos was confirmed from industrial histories in 80% of cases, the commonest industries involved being shipbuilding and repairing in men and sackware repairing in women. Lungs of industrial mesothelioma cases showed basal asbestosis in 17% and excessive asbestos bodies in almost all the rest. Quantitative comparison of asbestos bodies in lung smears from mesothelioma cases compared with lung smears from other Merseyside adults showed much higher counts in the mesothelioma cases. The interval from first exposure to asbestos until appearance of mesothelioma ranged between 13 and 63 years, with a mean of 42 years. We think the incidence of mesothelioma will continue to rise with the increased use of asbestos until about 40 years after adequate protective measures have been taken.

show abstract

Section: Histological Featuressupporting

confidence: 65%

Section: Chest Wall Operation Site and Diaphragmmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Diffuse malignant pleural mesothelioma and asbestos exposure

Whitwell¹,

Rawcliffe²

1971

Thorax

157

View full text Add to dashboard Cite

show abstract

“…Diffuse malignant mesotheliomata are recognized to have this tendency to spread along needle tracts, a tendency which can be attributed to some inherent biological property of the neoplasm (Rose, Palmer, and Lougheed, 1955;Godwin, 1957).…”

Section: Discussionmentioning

confidence: 99%

Aspiration biopsy of thoracic lesions

Lalli¹,

Naylor²,

Whitehouse³

1967

Thorax

View full text Add to dashboard Cite

We have performed percutaneous needle aspiration biopsy of intrathoracic lesrons under fluoroscopic control on 50 patients. Lesions as small as 1 to 15 cm. in diameter were aspirated. Thirty of the 36 cases of malignant neoplasm were diagnosed by this method. Of the 14 nonneoplastic cases, granuloma was diagnosed in two, and in eight of the remaining 12 the clinical diagnosis was supported by the nature of the aspirated material. Pneumothoraces are to be expected as a complication of the method. Most will be asymptomatic; a small proportion will require treatment. There will also be the occasional haemoptysis. The procedure can be quickly performed and it is well tolerated by the patient. It causes less discomfort than bronchoscopy or scalene lymph node biopsy. The interpretation of the cytological material presents no undue difficulty to the pathologist experienced in conventional pulmonary exfoliative cytology.

show abstract

“…Occasional fibres were found in 10 cases and the remaining three cases gave total counts of 0 298, 0-104, and 0 061 millions The principal difficulty in the pathological diagnosis of diffuse malignant mesothelioma of pleura or peritoneum lies in distinguishing the condition from metastatic carcinoma, spreading from a primary tumour in lung or elsewhere. The diagnostic criteria used in this study were based initially on the work of Campbell (1950), Godwin (1957), andMcCaughey (1958). Further valuable descriptions of the pathological features of mesothelioma have been given by Hourihane (1964), McCaughey (1965, Churg, Rosen, and Moolten (1965), Webster (1965), Whitwell and Rawcliffe (1971), and the UICC Working Group on Asbestos and Cancer (1965).…”

Section: T Asheroftmentioning

confidence: 99%

Epidemiological and quantitative relationships between mesothelioma and asbestos on Tyneside

Ashcroft

1973

J Clin Pathol

View full text Add to dashboard Cite

Fibre counts were also performed on lung samples from 18 smear-positive and 30 smear-negative routine necropsies. Cases with numerous coated fibres in the smear gave total fibre counts similar to those of mesothelioma cases without asbestosis. Routine cases with only one fibre in the smear usually yielded only occasional fibres on analysis. Coated and uncoated fibres were found in 13 out of 30 smear-negative cases, indicating a true incidence of 56 % of exposure to asbestos in the whole necropsy series. When compared with the mesothelioma series the difference in incidence of fibres remains statistically significant.The data suggest that, on Tyneside, exposure to asbestos sufficient to cause an appreciable risk of developing mesothelioma has usually occurred through occupational exposure rather than by general environmental pollution by asbestos.Although noted independently by Weiss (1953), van der Schoot (1958), and Konig (1960), the association between exposure to asbestos and diffuse malignant mesothelioma first attracted wide attention through the publication of a series of South African cases by Wagner, Sleggs, and Marchand (1960). Subsequent comparisons between cases of this pathologically controversial condition and control patients have, with one exception (Hagerstrand, 'Present address:

show abstract

Diffuse mesotheliomas.With comment on their relation to localized fibrous mesotheliomas

Cited by 95 publications

References 17 publications

Diffuse malignant pleural mesothelioma and asbestos exposure

Diffuse malignant pleural mesothelioma and asbestos exposure

Aspiration biopsy of thoracic lesions

Epidemiological and quantitative relationships between mesothelioma and asbestos on Tyneside

Contact Info

Product

Resources

About