Diffuse Neurobrucellosis of Cerebellum, Brainstem, Spinal Cord, and Cauda Equina: A case report and Literature review

Yazdi, Niloofar Ayoobi; Moosavi, Najme-sadat; Alesaeidi, Samira; Salahshour, Faeze; Ghaemi, Omid

doi:10.3941/jrcr.v16i5.3960

Cited by 3 publications

References 11 publications

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Characterization of 38 cases of Neurobrucellosis

Qi,

Niu,

Ren

et al. 2024

Preprint

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Aim：In this study, we thoroughly examine and discuss the clinical features, laboratory findings, treatment, and recovery of 38 neurobrucellosis cases. Additionally, we provide insights into the most recent research advances in the field of neurobrucellosis. Materials and methods：In this study, we collected general data, clinical characteristics, ancillary tests, and treatment plans of 38 cases of neurobrucellosis diagnosed and treated at the General Hospital of Ningxia Medical University from March 2012 to December 2022. Results：Among the 38 cases, 25 were male, and 23 had a clear history of cattle and sheep exposure. The most common clinical manifestations were fever (81.58%) and headache (76.32%). Brucella agglutination test was positive in 37 patients, and 37 patients showed increased protein in the cerebrospinal fluid. All 38 patients had a complete blood routine, with 11 cases showing abnormal white blood cell counts. Among the 29 patients who underwent cranial magnetic resonance imaging, 12 showed abnormalities. There were no in-hospital deaths among the patients. Conclusions：Neurobrucellosis exhibits diverse clinical manifestations and can be difficult to differentiate from tuberculous meningitis. Routine tests such as complete blood routine and cranial magnetic resonance imaging have limited diagnostic value for neurobrucellosis and are prone to clinical misdiagnosis and underdiagnosis. Patients with a history of contact with cattle and sheep in nearby grazing areas and presenting with symptoms such as fever and headache should undergo laboratory tests such as Brucella agglutination test or cerebrospinal fluid culture to establish an early and accurate diagnosis. Prompt initiation of treatment with doxycycline, rifampin, and ceftriaxone sodium triple therapy against Brucellosis is crucial in areas close to pastoral regions with potential cattle and sheep exposure.

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Characterization of 38 cases of Neurobrucellosis

Qi,

Niu,

Ren

et al. 2024

Preprint

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Case report: A case of abrupt stroke as the first symptom of neurobrucellosis

Liu

Gu²

2023

Front. Neurol.

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Acute cerebral infarction caused by small artery inflammatory disease, which is triggered by neurobrucellosis, is a rare condition that can be easily misdiagnosed. Neurobrucellosis is a rare complication of brucellosis that can present clinically as meningitis, meningoencephalitis, myelitis, neuritis, or psychosis. In this study, we report the case of a patient with neurobrucellosis who was hospitalized in the First People's Hospital of Lianyungang in September 2022; the primary symptom was weakness in the left limb for 14 h. The patient was discharged after receiving symptomatic and anti-Brucella medication.

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The research trend on neurobrucellosis over the past 30 years (1993–2023): a bibliometric and visualization analysis

Yang,

Pan,

Cai

et al. 2024

Front. Neurol.

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BackgroundBrucellosis is a zoonotic disease caused by Brucella infection, which is common in pastoral areas. Neurological involvement in brucellosis is relatively rare. But since 1993, continuous studies have been reporting neurological complications of brucellosis, collectively referred to as neurobrucellosis. A bibliometric analysis of existing literature outlines current research progress and gaps and provides guidance for the clinical treatment of neurobrucellosis, promoting patient health in the process of guiding clinical practice, and improving their quality of life.MethodsCiteSpace and VOSviewer are software tools to visualize research trends and networks. By selecting specific areas of interest and configuring the right parameters, the tools can visualize past research data. The study retrieved the literature from the Web of Science Core Collection Database and downloaded it in plain text file format. Citespace6.1.6, VOSviewer v1.6.20, and Microsoft Excel 16.59 were used for analyzing the following terms: countries, institutions, authors’ cooperation, journals, keywords, and co-citation.ResultsThere are eight key results. (1) The publication volume shows a general upward trend. (2) Turkey is the country with the highest publication volume and contributing institutions. (3) Giambartolomei GH, Gul HC, and Namiduru M are the authors with the highest number of publications. (4) Neurology is the journal that published the highest number of related articles (n = 12). (5) “Diagnosis,” “meningitis,” and “features” are the top three frequently occurring keywords. (6) Keyword clusters show “antibiotic therapy” and “cerebrospinal fluid” have future study value. (7) The burst analysis of the keywords also indicates that “cerebrospinal fluid” may become a prominent keyword in future research. (8) The co-citation analysis concludes three categories of the cited articles, which are diagnosis, therapy, and complications, indicating the past research direction.ConclusionThis study highlights the complexity of neurobrucellosis, presenting the need for advanced diagnostic techniques and multifaceted treatment approaches. While antibiotics remain the cornerstone of therapy, the use of corticosteroids to mitigate inflammatory responses shows promise, albeit with concerns about potential sequelae and relapse. Future research should focus on refining therapeutic strategies that address both the direct effects of infection and the broader immunological impacts to improve patient outcomes and quality of life.

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Diffuse Neurobrucellosis of Cerebellum, Brainstem, Spinal Cord, and Cauda Equina: A case report and Literature review

Cited by 3 publications

References 11 publications

Characterization of 38 cases of Neurobrucellosis

Characterization of 38 cases of Neurobrucellosis

Case report: A case of abrupt stroke as the first symptom of neurobrucellosis

The research trend on neurobrucellosis over the past 30 years (1993–2023): a bibliometric and visualization analysis

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