Diffuse neurofibroma of the ankle

Beggs, Ian; Gilmour, H M; Davie, R

doi:10.1016/s0009-9260(98)80319-x

Cited by 28 publications

(25 citation statements)

References 17 publications

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“…Although malignant transformation of neurofibromas has been reported in patients with NF-1, it rarely occurs in solitary diffuse neurofibromas 10 . Pain or enlargement of a neurofibroma may herald malignant transformation.…”

Section: Discussionmentioning

confidence: 99%

A Case of Diffuse Neurofibroma of the Scalp

et al. 2009

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Section: Discussionmentioning

confidence: 99%

A Case of Diffuse Neurofibroma of the Scalp

et al. 2009

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“…4-8 Intracranial extension of the extracranial variety of this tumor has rarely been reported 7 and malignant transformation is believed to be rare, however pain and enlargement may proclaim it. 2 Although Megahed and Hassel et al reported higher association rates, it is estimated that about 10% of these tumors are associated with NF 2,4,5,8,9 Some authors attribute the lower estimated incidence of NF-1 to the young age of patients with diffuse neurofibroma, which often precludes a reliable diagnosis of NF-1. 3 …”

Section: Discussionmentioning

confidence: 99%

Diffuse neurofibroma - an uncommon cause of alopecia

Macias

Rafael

Fernandes

et al. 2013

An. Bras. Dermatol.

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Although infrequent, alopecia can be caused by benign cutaneous tumours. Neurofibromas are common benign tumors that originate in the peripheral nerve sheath. Diffuse neurofibroma is a rare variant of neurofibroma that is thought to occur mainly in the head and neck of children and young adults. Histology generally shows an infiltrative tumor, composed of spindle cells in the dermis and subcutaneous tissue. Despite being rare, malignant transformation has been reported. The association between diffuse neurofibromas and neurofibromatosis type 1 still remains to be determined since some authors question the low incidence usually described. We report the case of a 42-year-old man who had a diffuse neurofibroma on the scalp presenting as alopecic plaques.

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“…These variants have no specific ultrasound features and are better imaged by MRI. However, sonography can show a lamellar pattern and increased blood flow in diffuse neurofibroma, 15 and plexiform neurofibroma may be multinodular. 16 Sonography can be used to guide biopsy of soft tissue masses.…”

Section: Neurilemoma and Neurofibromamentioning

confidence: 99%