Diffuse optical assessment of cerebral‐autoregulation in older adults stratified by cerebrovascular risk

Bahrani, Ahmed A.; Kong, Weikai; Shang, Yu; Huang, Chong; Smith, Charles D.; Powell, David K.; Jiang, Yang; Rayapati, Abner O.; Jicha, Gregory A.; Yu, Guoqiang

doi:10.1002/jbio.202000073

Cited by 11 publications

(18 citation statements)

References 81 publications

(165 reference statements)

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“…In the Framingham risk score, the risk of ASCVD was categorized into a low-risk group (Framingham risk score <15) or a high-risk group (Framingham risk score ≥15) as previously described. 27 Worsening of the Framingham risk score was defined as a change from the low-risk to the high-risk group.…”

Section: Calculation Of Fatty Liver Index Fibrosis-4 Index and Nafld Fibrosis Scorementioning

confidence: 99%

MAFLD better predicts the progression of atherosclerotic cardiovascular risk than NAFLD: Generalized estimating equation approach

Tsutsumi

Eslam

Kawaguchi

et al. 2021

Hepatology Research

145

118

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Aim: Metabolic associated fatty liver disease (MAFLD) partly overlaps with nonalcoholic fatty liver disease (NAFLD). Thus, using a generalized estimating equation (GEE) approach, we aimed to investigate the difference in worsening of atherosclerotic cardiovascular disease (ASCVD) risk between patients with MAFLD and NAFLD. We also investigated factors related to the difference between the two groups. Methods:We enrolled 2306 subjects with fatty liver (MAFLD 80.7%, NAFLD 63.4%). Subjects with MAFLD/NAFLD were sub-classified into three groups: NAFLD with no metabolic dysfunction (non-Met NAFLD), overlapping, and MAFLD with moderate alcohol consumption (mod-Alc MAFLD). ASCVD risk was estimated by non-invasive tests, including the Suita score. An event was defined as worsening of these scores from the low-risk to the high-risk group. Independent factors for the event were analyzed by Cox regression analysis with the GEE. Results:In Cox regression analysis, MAFLD (HR 1.08, 95% CI 1.02-1.15, p = 0.014) and alcohol consumption (20-39 g/day; HR 1.73, 95% CI 1.26-2.36, p = 0.001) were independently associated with worsening of the Suita score. In a subanalysis, the incidence of the event was significantly lower in non-Met NAFLD than in the overlapping group (HR 0.70, 95% CI 0.50-0.98, p = 0.042). However, no significant difference was observed in the incidence between the overlapping and mod-Alc MAFLD group (HR 1.19, 95% CI 0.89-1.58, p = 0.235). Conclusions:The GEE approach demonstrates that MAFLD better identifies patients with worsening of ASCVD risk than NAFLD. Moreover, the superiority of

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Section: Calculation Of Fatty Liver Index Fibrosis-4 Index and Nafld Fibrosis Scorementioning

confidence: 99%

MAFLD better predicts the progression of atherosclerotic cardiovascular risk than NAFLD: Generalized estimating equation approach

Tsutsumi

Eslam

Kawaguchi

et al. 2021

Hepatology Research

145

118

View full text Add to dashboard Cite

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“…Indeed, literature reports of autoregulation assessment with commercially available CW-NIRS systems abound, and more recently, assessment with DCS measurements of blood flow has become more prevalent. 388 , 432 , 461 – 463 While DCS provides direct measurements of CBF, NIRS measurements of blood volume, cerebral oxygenation, or the difference between the concentrations of oxy- and deoxy-hemoglobin have also been used as surrogates of CBF. Dynamic relationships between the optical measurements of CBF (or its surrogate) and mean arterial pressure (MAP), are then examined to yield measures of cerebral autoregulation.…”

Section: Clinical Applications Of Optical Spectroscopy and Imagingmentioning

confidence: 99%

Optical imaging and spectroscopy for the study of the human brain: status report

et al. 2022

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. This report is the second part of a comprehensive two-part series aimed at reviewing an extensive and diverse toolkit of novel methods to explore brain health and function. While the first report focused on neurophotonic tools mostly applicable to animal studies, here, we highlight optical spectroscopy and imaging methods relevant to noninvasive human brain studies. We outline current state-of-the-art technologies and software advances, explore the most recent impact of these technologies on neuroscience and clinical applications, identify the areas where innovation is needed, and provide an outlook for the future directions.

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“…The HCT might be more appropriate for differentiating psychiatric disorders when compared with the conventional VFT. Thus far, the comprehensive comparison between VFT and HCT has not been conducted, which is the main goal of this study ( 28 , 29 ).…”

Section: Introductionmentioning

confidence: 99%

fNIRS Evaluation of Frontal and Temporal Cortex Activation by Verbal Fluency Task and High-Level Cognition Task for Detecting Anxiety and Depression

et al. 2021

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Anxiety and depression are widespread psychosis which are believed to affect cerebral metabolism, especially in frontal and temporal cortex. The comorbidity patients of anxiety and depression (A&D) have more serious clinical symptoms. Functional near-infrared spectroscopy (fNIRS) is a noninvasive modality used to monitor human brain oxygenation, and it could be considered as a potential tool to detect psychosis which may lead to abnormal cerebral oxygen status when the brain is activated. However, how sensitive the cerebral oxygenation response to the cortex activation and whether these responses are consistent at different stages of A&D or different regions still remains unclear. In this study, a conventional physiological paradigm for cortex activation, i.e., verbal fluency task (VFT), and a relatively new paradigm, i.e., high-level cognition task (HCT), were compared to detect A&D through a longitudinal measurement of cerebral oxygen status by fNIRS. The A&D patients at the acute, consolidation and maintenance stages as well as the healthy subjects participated in the VFT and HCT paradigms, respectively. For the VTF paradigm, the subject was instructed to answer questions of phrase constructions within 60 s. For the HCT paradigm, the subject was instructed to categorize items, logical reasoning, and comprehensive judgment and write down the answers within 60 s. For most of the subjects, the oxy-Hb is found to increase remarkably, accompanied with a relatively small reduction in deoxy-Hb when subject to both paradigms. The statistical analyses show a relatively large variability within any group, leading to the significant difference that was only found between A&D at the acute stage and healthy subjects in the temporal lobe region (p < 0.001). Nevertheless, HCT would activate more oxygen increment when compared with the VFT, with a large integral value in oxy-Hb. On average, the oxy-Hb integral value of the A&D patients differs substantially at different stages when subject to HCT paradigm. Moreover, the prefrontal lobe and temporal lobe responses were more consistent to the HCT paradigm rather than the VFT paradigm. Under the VFT paradigm, however, no remarkable difference in integral value was found among the three stages, either at the prefrontal lobe or at the temporal lobe. This study indicated that HCT, which is intensively involved in brain function, would activate more oxygenation changes in the cerebral cortex. Additionally, with good performance at distinguishing different stages according to the oxy-Hb criterion, the HCT has the potential to evaluate the therapeutic effects for A&D patients.

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Diffuse optical assessment of cerebral‐autoregulation in older adults stratified by cerebrovascular risk

Cited by 11 publications

References 81 publications

MAFLD better predicts the progression of atherosclerotic cardiovascular risk than NAFLD: Generalized estimating equation approach

MAFLD better predicts the progression of atherosclerotic cardiovascular risk than NAFLD: Generalized estimating equation approach

Optical imaging and spectroscopy for the study of the human brain: status report

fNIRS Evaluation of Frontal and Temporal Cortex Activation by Verbal Fluency Task and High-Level Cognition Task for Detecting Anxiety and Depression

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