Diffuse optical tomography reconstruction method using ultrasound images as prior for regularization matrix

Abstract

, "Diffuse optical tomography reconstruction method using ultrasound images as prior for regularization matrix," J. Biomed. Opt. Abstract. Ultrasound-guided diffuse optical tomography (DOT) is a promising imaging technique that maps hemoglobin concentrations of breast lesions to assist ultrasound (US) for cancer diagnosis and treatment monitoring. The accurate recovery of breast lesion optical properties requires an effective image reconstruction method. We introduce a reconstruction approach in which US images are encoded as prior information for regularization of the inversion matrix. The framework of this approach is based on image reconstruction package "NIRFAST." We compare this approach to the US-guided dual-zone mesh reconstruction method, which is based on Born approximation and conjugate gradient optimization developed in our laboratory. Results were evaluated using phantoms and clinical data. This method improves classification of malignant and benign lesions by increasing malignant to benign lesion absorption contrast. The results also show improvements in reconstructed lesion shapes and the spatial distribution of absorption maps.

Chromophore decomposition in multispectral time-resolved diffuse optical tomography

“…Thus compared to the results obtained with the standard code, the prior spatial information of the inclusion improves significantly the accuracy of the quantification and compensates the quantification degradation due to depth. These observations are in agreement with results reported in recent works [29][30][31], where the use of other techniques (such as ultrasound imaging) to detect the position and shape of the inclusions (i.e. the a priori information) have been demonstrated useful to improve tomographic reconstructions.…”

“…We have demonstrated in [19] that this improves significantly the accuracy of the retrieved absorption coefficient. The assumption of a known geometry is justified when dealing with multimodal imaging techniques like for example the combination of diffuse optical imaging with ultrasound imaging [29][30][31].…”

Spectral correction for handheld optoacoustic imaging by means of near‐infrared optical tomography in reflection mode

“…This means that, if we were to assess SO 2 values in arteries, the estimation error could be reduced from >30% to <10%. This error could potentially be further reduced by exploiting the full capacity of the hybrid OA/US/NIROT modality functioning on the basis of a mutual feedback system, where OA and US images are used to provide NIROT reconstructions with a priori knowledge . Such mutual feedback could also be used to facilitate the interpretation of the quantitative data delivered in vivo by OA, NIROT and US.…”

Small-animal 360-deg fluorescence diffuse optical tomography using structural prior information from ultrasound imaging

“…24 Within the past five years, US-guided DOT has been used to reconstruct the hemoglobin concentrations of lesions and assist for cancer diagnosis, monitoring, and treatment. 30,31 Althobaiti et al evaluate the performance of the direct regularization imaging technique using the US priors in the reconstruction of DOT. They conduct both phantom and clinical experiments.…”