Diffuse osteoblastic metastases from an intracranial glioma

Schatzki, Stefan C.; McIlmoyle, G.; Lowis, Stephen P.

doi:10.2214/ajr.128.2.321

Cited by 18 publications

(6 citation statements)

References 11 publications

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“…As with our patient, the bone marrow biopsy was normal and the diagnosis of PDLG was made post-mortem. Other reports have recognized that glial tumors can metastasize to bone [22,23]. Unfortunately, our patient's bony lesions were not examined at autopsy.…”

Section: Discussionmentioning

confidence: 84%

Primary diffuse leptomeningeal gliomatosis mimicking a chronic inflammatory meningitis

Turkeltaub

Lee

et al. 2009

Journal of the Neurological Sciences

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Section: Discussionmentioning

confidence: 84%

Primary diffuse leptomeningeal gliomatosis mimicking a chronic inflammatory meningitis

Turkeltaub

Lee

et al. 2009

Journal of the Neurological Sciences

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“…For patients with GBM metastases, the findings can either be discovered in a symptomatic patient who underwent subsequent imaging, or incidentally on a routine surveillance bone scan. The bone involvement seen with GBM can be osteolytic, 23,24 osteoblastic, 16,36 or mixed on plain radiographs and computed tomography imaging. Both magnetic resonance imaging (MRI) with gadolinium as well as Tc-99m single-photon emission computed tomography bone scans are sensitive to detect vertebral body metastases from GBM.…”

Section: Imagingmentioning

confidence: 99%

Extraneural Glioblastoma Multiforme Vertebral Metastasis

et al. 2016

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Glioblastoma multiforme (GBM) is the most common malignant central nervous system tumor; however, extraneural metastasis is uncommon. Of those that metastasize extraneurally, metastases to the vertebral bodies represent a significant proportion. We present a review of 28 cases from the published literature of GBM metastasis to the vertebra. The mean age at presentation was 38.4 years with an average overall survival of 26 months. Patients were either asymptomatic with metastasis discovered at autopsy or presented with varying degrees of pain, weakness of the extremities, or other neurologic deficits. Of the cases that included the time to spinal metastasis, the average time was 26.4 months with a reported survival of 10 months after diagnosis of vertebral metastasis. A significant number of patients had no treatments for their spinal metastasis, although the intracranial lesions were treated extensively with surgery and/or adjuvant therapy. With increasing incremental gains in the survival of patients with GBM, clinicians will encounter patients with extracranial metastasis. As such, this review presents timely information concerning the presentation and outcomes of patients with vertebral metastasis.

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“…[16] However, the report of osteosclerotic metastasis from anaplastic astrocytoma is relatively rare with only a few reports in previous literatures. [6,7,17,18] As multiple extracranial osteosclerotic metastases can easily present as a carcinoma of unknown primary, especially in absence of obvious CNS symptoms, an origin of primary brain tumor should not be ignored. We emphasize that ECMs of astrocytoma should be kept as a differential diagnosis in a case of occult primary with osteosclerotic metastasis.…”

Section: Discussionmentioning

confidence: 99%

Extracranial bone metastases from recurrent anaplastic astrocytoma on FDG PET/CT

Li¹,

2017

Medicine

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Objective:Extracranial bone metastases from astrocytoma are rare and frequently detected as part of multiorgan metastases. It is extremely rare for astrocytoma to have extracranial bone metastases alone. The importance of whole-body fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) imaging in evaluating extracranial metastasis (ECMs) has not been described effectively due to the rarity of this event. The purpose of our case report is to emphasize the role of FDG PET/CT in the assessment of tumor recurrence and extracranial bone metastases from anaplastic astrocytoma.Methods and materials:A 25-year-old woman was firstly admitted with a 4-month history of progressive blurred vision, and 2-month history of intermittent headache. Presurgical MRI imaging revealed a large mass in the left trigone of lateral ventricle. Subsequently, she underwent tumor resection, radiotherapy and chemotherapy. A final pathological diagnosis of anaplastic astrocytoma (WHO III) was made. Nearly 12 months after the surgery, the follow-up brain MR imaging revealed a contrast-enhanced lesion in the site of operative region. Whole-body FDG PET/CT imaging was performed to evaluate the situation.Results:Postoperative brain FDG PET/CT showed an abnormal focal FDG uptake corresponding to the contrast-enhanced lesion in the operative area, suggesting a tumor recurrence. Whole-body FDG PET/CT also showed multiple FDG-avid osteosclerotic lesions in the body. It was highly suggestive of extracranial bone metastases. A subsequent open bone biopsy of FDG-avid lesion in right iliac crest was performed. Histopathological and immunohistochemical findings indicated characteristic of glioma. The patient died 1 month later, nearly 13 months after the initial diagnosis.Conclusions:ECMs from anaplastic astrocytoma are extremely rare but they do occur. Whole-body FDG PET/CT imaging with inclusion of brain was valuable in differentiating tumor recurrence from radiation necrosis and in detecting uncommon extracranial bone metastases from anaplastic astrocytoma, which were closely related to prognosis of this disease.

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Diffuse osteoblastic metastases from an intracranial glioma

Cited by 18 publications

References 11 publications

Primary diffuse leptomeningeal gliomatosis mimicking a chronic inflammatory meningitis

Primary diffuse leptomeningeal gliomatosis mimicking a chronic inflammatory meningitis

Extraneural Glioblastoma Multiforme Vertebral Metastasis

Extracranial bone metastases from recurrent anaplastic astrocytoma on FDG PET/CT

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