Diffuse panbronchiolitis in China: analysis of 45 cases

Ding, Ke; Liu, Miaobing; Wu, Junchen; Ma, Haiying; Fang, Xiutong; Miao, Guobin; Zhang, Lin

doi:10.1097/00029330-200711020-00021

Cited by 13 publications

(13 citation statements)

References 7 publications

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“… 10 Japanese scholars have reported extensively about GS combined with DPB or DPB‐like pulmonary manifestation. 4 , 5 The mechanism of DPB presentation in GS patients is not completely clear. Studies have suggested that the over‐reaction of lymphocytes associated with human leucocyte antigen‐B54 (HLA‐B54) in respiratory bronchioles and the recurrent and/or persistent bacterial infection caused by thymomas‐induced reduction in the immunocompetence of B lymphocytes are related.…”

Section: Discussionmentioning

confidence: 99%

“…Chinese literature shows that most patients were misdiagnosed as chronic bronchitis, COPD or other lung diseases before diagnosis. 4,12,15 The presence of sinusitis and the isolation of P. aeruginosa in the sputum are often associated with DPB, and the understanding of such association may improve the diagnosis. 4,16 The patient in this case had recurrent cough and expectoration for 3 years.…”

Section: Discussionmentioning

confidence: 99%

“…4,12,15 The presence of sinusitis and the isolation of P. aeruginosa in the sputum are often associated with DPB, and the understanding of such association may improve the diagnosis. 4,16 The patient in this case had recurrent cough and expectoration for 3 years. Before the diagnosis of DPB, she was misdiagnosed as having COPD, which may be related to clinicians' insufficient understanding of DPB.…”

Section: Discussionmentioning

confidence: 99%

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Good's syndrome with diffuse panbronchiolitis as the prominent manifestation: A case and literature review

Luo

Wang

et al. 2021

Respirology Case Reports

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Good's syndrome (GS) is characterized by thymoma combined with adult‐onset immunodeficiency. Diffuse panbronchiolitis (DPB) is a chronic inflammatory airway disease, which predominantly affects East Asians. Japanese scholars have reported extensively about GS combined with DPB or DPB‐like pulmonary manifestation. However, such reports are rare in China. We report here a case of GS in China with DPB as the prominent manifestation and carry out a literature review accordingly. Our review indicates that in adults with DPB‐like clinical manifestations, thymic lesions should be excluded and related immune function tests should be performed to exclude GS to avoid missed diagnosis and misdiagnosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Good's syndrome with diffuse panbronchiolitis as the prominent manifestation: A case and literature review

Luo

Wang

et al. 2021

Respirology Case Reports

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“…In nine of the reviewed cases of adult diagnoses, onset of symptoms was reported as occurring in childhood. . Thus, DPB can present at all ages from childhood to the elderly and is neither limited to Southeast Asian ethnic populations nor limited to that region.…”

Section: Discussionmentioning

confidence: 99%

Diffuse panbronchiolitis: A progressive fatal lung disease that is curable with azithromycin, but only if diagnosed!

Weinberger

Lesser

2019

Pediatric Pulmonology

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Diffuse panbronchiolitis (DPB) is a rare progressive and eventually fatal pulmonary disease first identified in Japan and initially seen predominantly in Southeast Asia.Macrolide antibiotics rapidly reverse symptoms and pathology, and their use increased the 5 and 10-year survival from 50 and 30 percent, respectively, to over 90%. Review of 181 case reports from previous publications found patients with DPB commonly had their pulmonary symptoms preceded by rhinosinusitis, frequently by many years. Long delays in diagnosis for many years were common. The review further identified DPB in all ethnic groups and multiple areas outside of Southeast Asia. Although diagnosis was most commonly made in adults, 13% of the diagnoses were made in children and nine of the adult cases described onset in childhood. Few cases of relapse were reported, but extended periods of monitoring after treatment were not generally present. K E Y W O R D S diffuse lung disease, diffuse panbronchiolitis, international health, Interstitial Lung Disease (ILD), lung pathology Pediatric Pulmonology. 2019;54:457-462.wileyonlinelibrary.com/journal/ppul

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“…Pathologic criteria include 1) diffuse, bilateral, chronic inflammatory airway disease; 2) predominant involvement of the walls of respiratory bronchioles and adjacent centrilobular regions; and 3) interstitial accumulation of foamy macrophages [ 10 ]. Typical features seen include thickening of the walls of the respiratory bronchioles, transmural and peribronchial infiltration by lymphocytes, plasma cells, and histocytes [ 11 ]. The inflammatory infiltrate destroys the bronchiolar epithelium and extends to peribronchiolar spaces, but most of the alveoli are unaffected [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Diffuse panbronchiolitis: not just an Asian disease: Australian case series and review of the literature

Anthony¹,

Singham²,

Soans³

et al. 2009

Biomed. Imaging Interv. J.

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Diffuse panbronchiolitis is a disease of obscure aetiology that is traditionally associated with Asian ethnicity. We propose that this disease also occurs in Caucasians and the incidence in this population is greater than currently recognised. We further propose that high resolution computed tomography (HRCT) and response to macrolide therapy should be relied upon to make this diagnosis without verification by lung biopsy. In most circumstances, obtaining a biopsy for histopathology is not practical, and the disease may then be mistaken for other more common airway diseases. Accuracy of diagnosis is important as untreated disease is associated with a poor prognosis, and effective treatment is available. We report four out of a series of cases as evidence that DPB is in fact more common in the Western population than is currently understood.

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Diffuse panbronchiolitis in China: analysis of 45 cases

Cited by 13 publications

References 7 publications

Good's syndrome with diffuse panbronchiolitis as the prominent manifestation: A case and literature review

Good's syndrome with diffuse panbronchiolitis as the prominent manifestation: A case and literature review

Diffuse panbronchiolitis: A progressive fatal lung disease that is curable with azithromycin, but only if diagnosed!

Diffuse panbronchiolitis: not just an Asian disease: Australian case series and review of the literature

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