Diffuse pancreatic neuroendocrine tumor: A rare presentation

Bhargava, Peeyush; Haque, Kabiul; Yang, Zhiyun; Sangster, Guillermo

doi:10.4103/ijnm.ijnm_73_18

Cited by 7 publications

(8 citation statements)

References 14 publications

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“…[4][5][6][8][9][10][11][12] A few case reports showed diffuse pancreatic activity in pancreatic neuroendocrine tumor on somatostatin receptor imaging, as shown in our cases. [4][5][6] Nuclear medicine physicians should be aware of this rare pattern of diffuse pancreatic activity on somatostatin receptor imaging in pancreatic neuroendocrine tumor.…”

supporting

confidence: 82%

“…7,8 Pancreatic neuroendocrine tumor with diffuse involvement of the entire pancreas is rare. [4][5][6][8][9][10][11][12] On imaging, diffuse pancreatic neuroendocrine tumor may show diffuse enlarged or normal-sized pancreas and may mimic acute or chronic pancreatitis, autoimmune pancreatitis, or lymphoma. [4][5][6][8][9][10][11][12] A few case reports showed diffuse pancreatic activity in pancreatic neuroendocrine tumor on somatostatin receptor imaging, as shown in our cases.…”

mentioning

confidence: 99%

“…Maximum intensity projection PET (C), reformatted transvers CT (D), corresponding PET (E), and fused (F) images showed diffusely intense activity (SUV max , 62) of the entire pancreas (arrows), suggestive of diffuse pancreatic neuroendocrine tumor. [4][5][6] The patient refused treatment and was lost to follow-up. Pancreatic neuroendocrine tumor typically appears as a solitary mass.…”

mentioning

confidence: 99%

“…[4][5][6][8][9][10][11][12] On imaging, diffuse pancreatic neuroendocrine tumor may show diffuse enlarged or normal-sized pancreas and may mimic acute or chronic pancreatitis, autoimmune pancreatitis, or lymphoma. [4][5][6][8][9][10][11][12] A few case reports showed diffuse pancreatic activity in pancreatic neuroendocrine tumor on somatostatin receptor imaging, as shown in our cases. [4][5][6] Nuclear medicine physicians should be aware of this rare pattern of diffuse pancreatic activity on somatostatin receptor imaging in pancreatic neuroendocrine tumor.…”

mentioning

confidence: 99%

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Somatostatin Receptor PET Imaging in Diffuse Pancreatic Neuroendocrine Tumor

Zhao¹,

Dong²,

He³

et al. 2023

Clin Nucl Med

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Somatostatin receptor imaging findings of pancreatic neuroendocrine tumor with diffuse involvement of the pancreas are rarely reported. We present somatostatin receptor PET imaging findings in 3 cases of diffuse pancreatic neuroendocrine tumor. One case showed diffuse swelling and diffusely intense activity of the pancreas with multiple metastases in the peripancreatic lymph nodes and liver. The other 2 cases showed diffusely intense activity of the pancreas without metastasis. The pancreatic tumor extended into the duodenum in all the 3 cases. Familiarity with this rare pattern of radiotracer uptake in pancreatic neuroendocrine tumor may be helpful for the diagnosis.

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supporting

confidence: 82%

mentioning

confidence: 99%

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confidence: 99%

mentioning

confidence: 99%

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Somatostatin Receptor PET Imaging in Diffuse Pancreatic Neuroendocrine Tumor

Zhao¹,

Dong²,

He³

et al. 2023

Clin Nucl Med

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“…Total pancreatectomy was performed. The histological sample of the pancreas showed low-grade diffuse pancreatic neuroendocrine tumor compatible with G1 PNETs in IHC [19].…”

Section: Etiology and Demographicsmentioning

confidence: 98%

Pancreatic Neuroendocrine Tumor presenting as a diffuse pancreatic enlargement, case report and review of literature

et al. 2021

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Pancreatic neuroendocrine tumors are rare neoplasms that comprise 1-2% of all pancreatic tumors. However, they are the second most common solid pancreatic neoplasms. They have a wide range of imaging appearances and they can show common to very rare imaging presentations. Most of the time they are solitary well-marginated enhancing solid mass arising in a certain aspect of the pancreas. We present a case report of a 41-year-old female who underwent clinical work-up for abdominal pain, loss of appetite and weight loss for the past year. Ultrasound, computed tomography, and magnetic resonance imaging show diffuse homogenous pancreatic enlargement without contour deformity or a focal mass. Lymphoma and autoimmune pancreatitis were suggested based on imaging findings but IGg4 level and other lab data were normal. Endoscopic ultrasonography confirmed the diffuse enlargement of the pancreas without peripheral structures involvement. The pathological results of multiple fine-needle aspiration biopsy from all parts of the enlarged pancreas revealed a low-grade neuroendocrine tumor. CASE REPORTA 41-year-old female patient with a medical history significant for Hashimoto's thyroiditis presented with nonspecific abdominal pain that sometimes radiates into the back, loss of appetite and weight loss of 5 kilograms for the past year. There is no history of nausea, vomiting, diarrhea, melena, or bleeding. Physical examination was normal. Laboratory data were normal except for elevated CA19-9 (247 units per milliliter with a normal range of 0-37 in a healthy person).In the course of workup, an abdominal ultrasound (US) was performed. A marked pancreatic enlargement was found with mild heterogeneous echo-pattern and no obvious focal mass or calcification.

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Diffuse Involvement of Pancreas Should Raise Suspicion of Mahvash Disease, an Autosomal Recessive Pancreatic Neuroendocrine Tumor Syndrome

Yu¹

2022

Academic Radiology

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Diffuse pancreatic neuroendocrine tumor: A rare presentation

Cited by 7 publications

References 14 publications

Somatostatin Receptor PET Imaging in Diffuse Pancreatic Neuroendocrine Tumor

Somatostatin Receptor PET Imaging in Diffuse Pancreatic Neuroendocrine Tumor

Pancreatic Neuroendocrine Tumor presenting as a diffuse pancreatic enlargement, case report and review of literature

Diffuse Involvement of Pancreas Should Raise Suspicion of Mahvash Disease, an Autosomal Recessive Pancreatic Neuroendocrine Tumor Syndrome

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