Diffuse Polyclonal B-Cell Lymphoma during Primary Infection with Epstein–Barr Virus

Robinson, James E.; Brown, Nathaniel; Andiman, Warren A.; Halliday, Karen R.; Francke, Uta; Robert, Marie; Andersson-Anvret, Maria; Horstmann, Dorothy M.; Miller, George

doi:10.1056/nejm198006053022306

Cited by 137 publications

(26 citation statements)

References 21 publications

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“…EBV is a human B-cell lymphotropic virus that is the etiologic agent of infectious mononucleosis. EBV also induces fatal B-cell lymphomas in immunocompromised patients (13) and is associated with both Burkitt lymphoma and nasopharyngeal carcinoma (14,15). Homosexual men, one of the main groups at risk for HIV infection, have a 50% prevalence of active EBV infection (EBV early antigen, 21:40) even when seronegative for HIV, whereas in healthy heterosexuals the prevalence of active EBV infection is only 5% (16).…”

mentioning

confidence: 99%

An Epstein-Barr virus immediate-early gene product trans-activates gene expression from the human immunodeficiency virus long terminal repeat.

Kenney

Kamine

Markovitz

et al. 1988

Proc. Natl. Acad. Sci. U.S.A.

126

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confidence: 99%

An Epstein-Barr virus immediate-early gene product trans-activates gene expression from the human immunodeficiency virus long terminal repeat.

Kenney

Kamine

Markovitz

et al. 1988

Proc. Natl. Acad. Sci. U.S.A.

126

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“…9, 20, 24, 28, 33], At autopsy a great number of EBNA-positive blast cells could be demonstrated in the lymphatic tissue [2,3,24], It was reported that a monoclonal B cell lym phoma may emerge from the proliferating polyclonal B cell population [6. 9, 14, 31].…”

Section: Discussionmentioning

confidence: 99%

Demonstration of Epstein-Barr Virus in Malignant Non-Hodgkin’s Lymphomas

Wutzler¹,

Färber²,

Sauerbrei³

et al. 1986

Oncology

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Lymph nodes or tumor biopsies of 60 persons suspected of having a malignant lymphoma were examined for the presence of Epstein-Barr virus nuclear antigen (EBNA) by anticomplement immunofluorescence. In 8 cases the tissue specimens were also assayed for Epstein-Barr virus (EBV) DNA by nucleic acid hybridization. Serum samples of patients and controls were tested for EBV-related antibodies. The histological tests in 37 cases showed a malignant non-Hodgkin lymphoma, and in 23 cases a reactive lymphadenopathy. A Burkitt lymphoma of a European boy and a polymorphic centroblastoma contained EBNA and approximately 27 or 30 genome equivalents EBV DNA per cell, respectively. EBNA was also demonstrated in about 20% of the cells of a lymph node from a patient with recurrent reactive lymphadenopathy.

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“…Other studies of immune abnormalities in patients with AILD have implicated Epstein-Barr virus (38), impaired suppressor T cell function (9), and autonomous B cell hyperactivity (7). Moreover, occasional patients with AILD have been found to manifest impaired Ig production (10 (2-4, 6, 40-42).…”

Section: Discussionmentioning

confidence: 99%