Diffuse primary leptomeningeal gliomatosis

Dávila, Gerardo; Duyckaerts, Charles; Lazareth, J. P.; Poisson, M; Delattre, Jean‐Yves

doi:10.1007/bf01050262

Cited by 38 publications

(29 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Clinical manifestations of diffuse primary leptomeningeal gliomatosis include headache, nausea, vomiting, and ventricular dilation followed by cranial and spinal nerve pareses. 1,2,5,6,11,14,16) Interestingly, CSF protein levels were elevated when measured in previously reported cases. 1,2,6,11) However, tumor cells were not observed in those cases in which cytological examination was per-formed.…”

Section: Discussionmentioning

confidence: 89%

Pontine Glioblastoma Multiforme Initially Presenting With Leptomeningeal Gliomatosis. Case Report.

Motoyama

Ogi

Nabeshima

2002

Neurol. Med. Chir.(Tokyo)

View full text Add to dashboard Cite

A 49-year-old female presented with diffuse leptomeningeal gliomatosis as the initial manifestation of pontine glioblastoma. Magnetic resonance imaging initially revealed diffuse leptomeningeal enhancement caused by metastatic deposits, predominantly along the basal cistern and bilateral sylvian fissures. The primary pontine lesion appeared as hypointense on T 1 -weighted imaging and hyperintense on T 2 -weighted imaging, but with no enhancement by gadolinium-diethylenetriaminepenta-acetic acid. There was no diffuse enlargement of the pons. The patient died 11 months after the initial presentation. The primary lesion in the pons was histologically confirmed at autopsy. Diffuse enhancement of leptomeningeal dissemination may occur as the initial manifestation of non-enhanced pontine glioblastoma.

show abstract

Section: Discussionmentioning

confidence: 89%

Pontine Glioblastoma Multiforme Initially Presenting With Leptomeningeal Gliomatosis. Case Report.

Motoyama

Ogi

Nabeshima

2002

Neurol. Med. Chir.(Tokyo)

View full text Add to dashboard Cite

show abstract

“…Secondary gliomatosis arises rarely in patients with low-grade glioma (Civitello et al, 1988). Secondary gliomatosis may be the presenting symptom of glioma in rare cases (Davila et al, 1993;Herman et al, 1995). In many instances of secondary CSF dissemination of malignant glioma, the primary lesion is very small and can only be found at autopsy (Ashworth and Gordon, 1994).…”

Section: Discussionmentioning

confidence: 99%

“…In most cases, leptomeningeal propagation of glioma is considered untreatable and is seen as an endstage complication of malignant glioma. Due to the nonregional nature of this complication, chemotherapy is sometimes attempted, but it has limited therapeutic efcacy (Davila et al, 1993;Delattre et al, 1989;Kandt et al, 1984;Poisson et al, 1995).…”

mentioning

confidence: 99%

Intractable vomiting from glioblastoma metastatic to the fourth ventricle: Three case studies

Hassenbusch¹,

Maor²,

Pfeffer³

et al. 2002

Neuro-Oncol

View full text Add to dashboard Cite

Dissemination of malignant glioma to the fourth ventricle with metastatic deposits and intractable vomiting is rare.Leptomeningeal extension of malignant glioma is an uncommon condition that has been reported in patients with end-stage disease and is usually unresponsive to any treatment modality. We describe 3 patients with progressing recurrent glioblastoma multiforme in whom leptomeningeal invasion manifested itself as intractable vomiting due to tumor metastases in the oor of the fourth ventricle. All patients received additional radiation therapy focused to the posterior fossa, with complete resolution of vomiting occurring within 10 days after irradiation. The remission of symptoms in these patients persisted until their death 3-4 months after the repeat radiation therapy. These reports indicate that additional focused radiation should be considered because of its signi cant therapeutic effect in alleviating intractable nausea and vomiting in patients with glioma metastasized to the posterior fossa. Neuro-Oncology 4, 129-133, 2002 (Posted to Neuro-Oncology [serial online], Doc. 01-053, February 1, 2002 T he clinical picture of tumor invasion of the leptomeninges is well recognized as a problem of systemic cancer (Wasserstrom et al., 1982), but is less frequent in gliomas. A secondary type of leptomeningeal extension of malignant glioma, also called secondary gliomatosis, has been reported and is associated with dis-

show abstract

“…The development and use of MRI has increased this figure to 91% [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27]. Additionally, MRI of the spine has revealed abnormalities in 100% of the reported cases studied in this fashion [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27]. Clearly, the number of reported cases of PDLG has increased parallel to the development and use of MRI as a clinical adjuvant.…”

Section: Discussionmentioning

confidence: 99%

“…Prior to high resolution imaging, the definitive diagnosis of PDLG required autopsy to rule out a primary parenchymal source for the leptomeningeal process [1,2,3,4,5,6,7,8]. Many of the cases reported as representing PDLG are complicated by focal parenchymal involvement, which has been interpreted as a secondary parenchymal infiltration of a primary leptomeningeal glioma [29,30,31,32,33,34,35,36].…”

Section: Introductionmentioning

confidence: 99%

Primary Diffuse Leptomeningeal Gliomatosis

et al. 2009

View full text Add to dashboard Cite

Background: Primary diffuse leptomeningeal gliomatosis (PDLG) is a rare presentation of a primary central nervous system glial tumor. Methods: Four case reports of PDLG in young males aged 14–24 years are presented. These reports are discussed in the context of the existing literature. Results: The clinical presentation of 4 new cases of PDLG resembled chronic meningitis with and without polyradiculopathy. Spinal fluid studies are typically nondiagnostic, but characteristically show elevated opening pressure, an elevated protein level, and a relative paucity of cellular reaction. An accurate antemortem diagnosis required contrast-enhanced imaging and meningeal biopsy in all 4 of our cases. Treatment strategies including craniospinal radiation and chemotherapeutic approaches, alone or in combination, have not been proven to alter the course of the disease. Initial responses to temozolomide and radiation treatments in all 4 of our cases were promising, resulting in temporary stabilization of the disease and prolonging life expectancy over what was previously reported in the literature. Conclusion: Total neuroaxis contrast-enhanced MRI scanning is required for directing biopsy confirmation and detecting the extent of the disease. More effective therapeutic strategies are needed, but the combination of temozolomide and radiation therapy may slow disease progression.

show abstract

Diffuse primary leptomeningeal gliomatosis

Cited by 38 publications

References 22 publications

Pontine Glioblastoma Multiforme Initially Presenting With Leptomeningeal Gliomatosis. Case Report.

Pontine Glioblastoma Multiforme Initially Presenting With Leptomeningeal Gliomatosis. Case Report.

Intractable vomiting from glioblastoma metastatic to the fourth ventricle: Three case studies

Primary Diffuse Leptomeningeal Gliomatosis

Contact Info

Product

Resources

About