Diffuse pulmonary uptake on FDG-PET with normal CT diagnosed as intravascular large B-cell lymphoma: a case report and a discussion of the causes of diffuse FDG uptake in the lungs

Wagner, Todd H.; Brechemier, D.; Dugert, Eric; Guellec, Sandrine Le; Julian, Anne; Hitzel, Anne; Beyne-Rauzy, O.

doi:10.1102/1470-7330.2012.0002

Cited by 24 publications

(21 citation statements)

References 24 publications

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“…In this setting, several authors have reported that FDG‐PET could be useful for the diagnosis of IVLBCL when this type of lymphoma is clinically suspected . The potential interests of FDG‐PET/CT in IVLBCL reported in literature are summarized in Table .…”

Section: Discussionmentioning

confidence: 99%

FDG-PET/CT is a pivotal imaging modality to diagnose rare intravascular large B-cell lymphoma: case report and review of literature

et al. 2014

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Intravascular large B-cell lymphoma (IVLBCL) remains a diagnostic challenge, because of non-specific findings on clinical, laboratory, and imaging studies. We present a case in which 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography was particularly useful to suspect the diagnosis, to detect unexpected locations, to guide contributive biopsy, and to assess the response to treatment. In case of initial negative results, FDG-PET should be repeated in the course of clinical evolution. In the presence of neurological or hormonal symptoms without brain magnetic resonance imaging abnormality, FDG-PET brain slices could depict additional pituitary and/or brain hypermetabolisms. We discuss the potential interests of FDG-PET in IVLBCL by a literature review.

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Section: Discussionmentioning

confidence: 99%

FDG-PET/CT is a pivotal imaging modality to diagnose rare intravascular large B-cell lymphoma: case report and review of literature

et al. 2014

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“…6 This disease is difficult to diagnose because of the unspecific nature of the symptoms. This difficulty to suspect the diagnosis facilitates disease progression and explains its high mortality, although if detected early, adequate chemotherapy treatment may be implemented to improve the survival, and, in some cases, even achieve complete disease remission.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary intravascular lymphoma detected by FDG PET-CT: A case report

Kohan

Paganini

Biedak

et al. 2013

Revista Española de Medicina Nuclear e Imagen Molecular (Englis

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“…Also, CT and echocardiographic features of pulmonary hypertension, noted in five of 11 (46%) patients in our cohort, and decreased diffusion capacity in pulmonary function may become clues for making a correct diagnosis. Several authors (12,(17)(18)(19) have reported that FDG PET is useful for diagnosis when IVL is clinically suspected. All patients who underwent FDG PET in our study showed increased FDG uptake in the corresponding lung lesions seen at CT.…”

Section: Thoracic Imaging: Ct and Pet Findings In Patients With Pulmomentioning

confidence: 99%

Pulmonary Intravascular Lymphomatosis: Clinical, CT, and PET Findings, Correlation of CT and Pathologic Results, and Survival Outcome

Jae¹,

Lee²,

Hwang³

et al. 2016

Radiology

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).q RSNA, 2016 Purpose:To describe clinical, computed tomographic (CT), and positron emission tomographic (PET) features, correlation of CT and pathologic results, and survival of patients with pulmonary intravascular lymphomatosis. Materials and Methods:The institutional review board approved this retrospective study with waiver of patient consent. Forty-two patients with pulmonary intravascular lymphomatosis were identified, 11 (26%) of whom showed lung involvement. CT features were correlated with histopathologic results. Clinical and survival outcomes were compared between patients with and those without pulmonary involvement by adopting the x 2 , Student t, or Kaplan-Meier analysis with log-rank tests. Results:At clinical presentation, all 11 patients showed B symptoms (systemic symptoms of fever, night sweats, and weight loss), 10 had respiratory and four had neurologic symptoms, and two had skin lesions. Patients received cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy with (n = 5) or without (n = 6) rituximab, and seven (64%) patients died. Patients with lung involvement showed reduced overall and recurrence-free survival (median; 10.8 and 18.9 months, respectively) compared with those without lung involvement (median, 18.4 and 31.0 months, respectively) (P = .338 and .065, respectively). The most common CT abnormality was bilateral ground-glass opacity (GGO, n = 10), with increased fluorodeoxyglucose uptake at PET/CT (seven of seven patients). GGO correlated histopathologically with the expanded alveolar septal vasculatures and perivascular spaces filled with neoplastic lymphoid cells. Conclusion:Pulmonary intravascular lymphomatosis appeared as bilateral GGO on CT images, with increased fluorodeoxyglucose uptake on PET/CT images. GGO on CT images correlated with the area of expanded alveolar septae because of distended vessels filled with neoplastic lymphoid cells.q RSNA, 2016

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Diffuse pulmonary uptake on FDG-PET with normal CT diagnosed as intravascular large B-cell lymphoma: a case report and a discussion of the causes of diffuse FDG uptake in the lungs

Cited by 24 publications

References 24 publications

FDG-PET/CT is a pivotal imaging modality to diagnose rare intravascular large B-cell lymphoma: case report and review of literature

FDG-PET/CT is a pivotal imaging modality to diagnose rare intravascular large B-cell lymphoma: case report and review of literature

Pulmonary intravascular lymphoma detected by FDG PET-CT: A case report

Pulmonary Intravascular Lymphomatosis: Clinical, CT, and PET Findings, Correlation of CT and Pathologic Results, and Survival Outcome

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